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Keywords: Cell polarization
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Journal Articles
J Cell Sci (2017) 130 (6): 1147–1157.
Published: 15 March 2017
...: GRAF1 mediates inactivation and endocytic removal of Rab8 from cell surface protrusions, thereby facilitating dynamic adjustment of the polarity axis. Rab8 GRAF1 Cell polarization Endocytosis Polarity establishment or breaking of symmetry is essential for migration, differentiation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (15): 3233–3239.
Published: 1 August 2014
... cells.   Front Physiol   2 , 58 . 10.3389/fphys.2011.00058 Gao   B. , Song   H. , Bishop   K. , Elliot   G. , Garrett   L. , English   M. A. , Andre   P. , Robinson   J. , Sood   R. , Minami   Y.   ( 2011 ). Wnt signaling gradients establish planar cell polarity...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (9): 2005–2016.
Published: 1 May 2014
...Kyriakos Kokkoris; Daniela Gallo Castro; Sophie G. Martin ABSTRACT Cell polarization relies on small GTPases, such as Cdc42, which can break symmetry through self-organizing principles, and landmarks that define the axis of polarity. In fission yeast, microtubules deliver the Tea1–Tea4 complex...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1660–1671.
Published: 15 April 2014
... organization and MT distribution might induce bias of the MT network during cell polarization. References Adams   C. L. , Nelson   W. J. , Smith   S. J. ( 1996 ). Quantitative analysis of cadherin-catenin-actin reorganization during development of cell-cell adhesion.   J. Cell Biol.   135...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (9): 2300–2314.
Published: 1 May 2012
..., preferential recruitment of supervillin to podosome subpopulations might both require and induce actomyosin contractility. Using siRNA and pharmacological inhibition, we demonstrate that supervillin and myosin IIA cooperate to regulate podosome lifetime, podosomal matrix degradation and cell polarization...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (5): 1099–1105.
Published: 1 March 2012
... Cell polarization Proper positioning of the nucleus is required for different cellular and developmental processes ( Reinsch and Gönczy, 1998 ; Burke and Roux, 2009 ). Actin-dependent nuclear movement has been described in migrating fibroblasts, astrocytes and neurons ( Gomes et al., 2005...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (2): 387–398.
Published: 15 January 2012
... and polarity in Dictyostelium . * Authors for correspondence ( iweber@irb.hr ; faix.jan@mh-hannover.de ) 28 7 2011 © 2012. 2012 Rac1 Cell motility Cell polarization FRET Actin cytoskeleton Rho GTPases Dictyostelium A major role of canonical small GTPases from the Rho...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2012) 125 (2): 340–349.
Published: 15 January 2012
... to form a reticulocyte. Most molecular events in enucleation remain unclear. Here we show that enucleation requires establishment of cell polarization that is regulated by the microtubule-dependent local activation of phosphoinositide 3-kinase (PI3K). When the nucleus becomes displaced to one side...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (24): 4267–4285.
Published: 15 December 2011
... of polarization has progressed as a result of various scratch-wound and cell migration studies, variations in culture conditions required for such assays have prevented a unified understanding of the intricacies of MTOC and nucleus positioning that result in cell polarization. Here, we employ a new SMRT...
Includes: Supplementary data
Journal Articles
J Cell Sci (2009) 122 (18): 3374–3384.
Published: 15 September 2009
...Nina Stenzel; Christian P. Fetzer; Rolf Heumann; Kai S. Erdmann Multi-PDZ (PSD-95/Discs large/Zonula-occludens-1) domain proteins play a crucial role in the establishment and maintenance of cell polarization. The novel multi-PDZ domain protein FRMPD2 is a potential scaffolding protein consisting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (14): 2406–2414.
Published: 15 July 2008
..., the Golgi complex and the centrosome localize behind the nucleus in cells that migrate in a constraint environment in vivo. Although a subject of considerable study, the causal relationship between cell polarization, cell locomotion and the positioning of the Golgi complex has remained unclear...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2008) 121 (5): 695–705.
Published: 1 March 2008
... mediated by adhesion receptors. The present findings demonstrate a new function of ORP3 as part of the machinery that controls the actin cytoskeleton, cell polarity and cell adhesion. Human embryonic kidney (HEK293) cells were cultured in Eagle-MEM (Sigma-Aldrich) supplemented with 10% heat-inactivated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2007) 120 (24): 4332–4344.
Published: 15 December 2007
...Tayamika Mseka; Jim R. Bamburg; Louise P. Cramer How formation of the front and rear of a cell are coordinated during cell polarization in migrating cells is not well understood. Time-lapse microscopy of live primary chick embryo heart fibroblasts expressing GFP-actin show that, prior to cell...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (10): 2085–2092.
Published: 15 May 2005
... Cell polarization Rho-family GTPases, such as Rho, Rac and Cdc42, cycle between a GTP-bound active state and a GDP-bound inactive state. The nucleotide state of Rho GTPases is controlled by three classes of regulator: guanine nucleotide exchange factors (GEFs), which promote the exchange of GDP...
Journal Articles
J Cell Sci (2004) 117 (7): 1091–1104.
Published: 1 March 2004
... an intact Tyr515 was indispensable. * Author for correspondence (e-mail: bjorn.obrink@cmb.ki.se ) 16 10 2003 © The Company of Biologists Limited 2004 2004 Cell adhesion molecule Cell junction Cell polarization Phosphorylation Protein localization motif CEACAM1...
Journal Articles
J Cell Sci (2003) 116 (22): 4513–4519.
Published: 15 November 2003
... Evanescent wave Cell polarization Post-Golgi vesicle Migration Secretion Fibroblasts develop pronounced morphological asymmetries when undergoing directed migration. This includes a large lamellipodium at the front and the nucleus at the back of the cell. The development of this asymmetry depends...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2002) 115 (6): 1273–1284.
Published: 15 March 2002
... between adjacent microvilli on the apical surfaces. Author for correspondence (e-mail: bjorn.obrink@cmb.ki.se ) 13 12 2001 © The Company of Biologists Limited 2002 2002 CEACAM1 Cell adhesion Cell polarization Microvilli Signal transduction CEACAM1 (carcinoembryonic...
Journal Articles
J Cell Sci (2001) 114 (15): 2787–2794.
Published: 1 August 2001
... both the translocation of Tat into the nucleus and the secretion of Tat from the cells (Battaglia et al., 1997 ). However, this Tat-microtubule interaction affects cell polarization and may result in further damage to the cell. Here we have shown that when Tat is expressed in Drosophila oocytes...