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Keywords: Cell migration
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Journal Articles
J Cell Sci (2022) 135 (22): jcs260241.
Published: 21 November 2022
... is limited. In vivo , progenitor cells directionally migrate from the surrounding loose mesenchyme towards regions of increasing matrix adherence (the condensation centers), which is accompanied by the upregulation of fibronectin. Here, we focused on the mechanisms of cell migration during mesenchymal cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (20): jcs260042.
Published: 20 October 2022
...Akash Chinchole; Kaisar Ahmad Lone; Shweta Tyagi ABSTRACT Attainment of proper cell shape and the regulation of cell migration are essential processes in the development of an organism. The mixed lineage leukemia (MLL or KMT2A) protein, a histone 3 lysine 4 (H3K4) methyltransferase, plays...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (8): jcs259493.
Published: 3 May 2022
... of nuclear stiffness. Cancer Metastasis Cell migration Cytoskeleton Nucleus Nuclear envelope Emerin Src Mechanotransduction Melanoma Research Alliance http://dx.doi.org/10.13039/100005190 688232 American Cancer Society http://dx.doi.org/10.13039/100000048 RSG-20-019...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (6): jcs259226.
Published: 14 March 2022
...Jan Faix; Klemens Rottner ABSTRACT The tightly coordinated, spatiotemporal control of actin filament remodeling provides the basis of fundamental cellular processes, such as cell migration and adhesion. Specific protein assemblies, composed of various actin-binding proteins, are thought to operate...
Journal Articles
J Cell Sci (2021) 134 (23): jcs258891.
Published: 9 December 2021
... of WAVE by CK1α protects it from premature proteasomal degradation. Drosophila Macrophages Cell migration Cell shape Lamellipodia Cell motility Actin Arp2/3 WAVE CK1α CK2 Phosphorylation Ubiquitin-dependent protein degradation Deutsche Forschungsgemeinschaft http://dx.doi.org...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (18): jcs259221.
Published: 24 September 2021
... TRPML1 (also known as MCOLN1), enabling the local activation of myosin II at the cell rear. Taken together, our findings identify Rab7b as the missing physical link between lysosomes and the actomyosin cytoskeleton, allowing control of immune cell migration through lysosomal signaling. This article has...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (8): jcs258574.
Published: 22 April 2021
... rear retraction in matrix-directed cell migration . Dev. Cell 51 , 460 - 475.e10 . 10.1016/j.devcel.2019.09.006 Heyworth , P. G. , Bohl , B. P. , Bokoch , G. M. and Curnutte , J. T. ( 1994 ). Rac translocates independently of the neutrophil NADPH oxidase components p47...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2021) 134 (6): jcs254359.
Published: 29 March 2021
...Zofia Ostrowska-Podhorodecka; Isabel Ding; Wilson Lee; Jelena Tanic; Sevil Abbasi; Pamma D. Arora; Richard S. Liu; Alison E. Patteson; Paul A. Janmey; Christopher A. McCulloch ABSTRACT Vimentin is a structural protein that is required for mesenchymal cell migration and directly interacts with actin...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2021) 134 (6): jcs240226.
Published: 22 March 2021
... to scaling relationships . J. Cell Biol. 216 , 305 - 315 . 10.1083/jcb.201610042 Cooper , J. A. ( 2013 ). Mechanisms of cell migration in the nervous system . J. Cell Biol. 202 , 725 - 734 . 10.1083/jcb.201305021 Corliss , B. A. , Ray , H. C. , Doty , R. W...
Journal Articles
J Cell Sci (2021) 134 (1): jcs244616.
Published: 13 January 2021
...Jie Liu; Zhongzhen Liu; Keng Chen; Wei Chen; Xiyuan Fang; Meng Li; Xuening Zhou; Ning Ding; Huan Lei; Chen Guo; Tao Qian; Yilin Wang; Lin Liu; Yonglong Chen; Hui Zhao; Ying Sun; Yi Deng; Chuanyue Wu ABSTRACT Cell migration involves front-to-rear asymmetric focal adhesion (FA) dynamics, which...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2020) 133 (18): jcs243683.
Published: 23 September 2020
...Anna V. Samarelli; Tilman Ziegler; Alexander Meves; Reinhard Fässler; Ralph T. Böttcher ABSTRACT Integrin function depends on the continuous internalization of integrins and their subsequent endosomal recycling to the plasma membrane to drive adhesion dynamics, cell migration and invasion. Here we...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (15): jcs248583.
Published: 5 August 2020
... of the membrane skeleton might enable spatiotemporal modulation of membrane mechanics during distinct developmental events. C. elegans spectrin binds to ankyrin, and these proteins function to regulate neural development. Cell migration Cytoskeleton Dendrite formation Membrane mechanics Spectrin...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (11): jcs242842.
Published: 11 June 2020
... (GR, also known as NR3C1) to regulate immunity, energy metabolism and tissue repair. Upon ligand binding, activated GR mediates cellular effects by regulating gene expression, but some GR effects can occur rapidly without new transcription. Here, we show that GCs rapidly inhibit cell migration...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2020) 133 (9): jcs241505.
Published: 11 May 2020
... cytoplasmic protrusions and increased cell migration. EML4–ALK V3 also recruits the NEK9 and NEK7 kinases to microtubules via the N-terminal EML4 microtubule-binding region. Overexpression of wild-type EML4, as well as constitutive activation of NEK9, also perturbs cell morphology and accelerates migration...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs236778.
Published: 28 April 2020
...-licence-1-1/ Summary: This work demonstrates a migratory mode of primarily round cancer cells in complex 3D environments and reveals a fundamentally new function for membrane blebs in cancer cell invasion. Membrane bleb Integrin ECM reorganization Cancer Cell migration Aberrant...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs235325.
Published: 30 March 2020
... of their pulsatile cytoskeletal network and tightly controlled cellular contractility underlie this transition. Actomyosin contractility Apical constriction Cell migration Drosophila Pulsed contractions During development, morphogenetic processes ultimately shape the organism ( Lecuit and Le Goff...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs238048.
Published: 6 March 2020
... filament turnover Cell migration T-cell development Deutsche Forschungsgemeinschaft 10.13039/501100001659 SFB 704 Differentiation of α,β T cells follows a complex sequence of molecular events that take place in spatially defined niches of the thymus. T-cell development comprises...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (4): jcs242834.
Published: 21 February 2020
... and phototoxicity. A workflow is presented to minimize the negative effects of IO for live imaging. Fluorescence microscopy Phototoxicity Cell migration Mitochondrial dynamics Microtubule dynamics Adhesion dynamics Fluorescence microscopy provides a convenient, selective and sensitive way...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2020) 133 (3): jcs233361.
Published: 4 February 2020
...Kuan-Jung Chen; Tsai-Chen Chiang; Chia-Jung Yu; Fang-Jen S. Lee ABSTRACT Cell migration requires the coordination of multiple signaling pathways involved in membrane dynamics and cytoskeletal rearrangement. The Arf-like small GTPase Arl4A has been shown to modulate actin cytoskeleton remodeling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (24): jcs236828.
Published: 13 December 2019
.... They mediate numerous functions, including cell–matrix adhesion, extracellular matrix degradation, mechanosensing and cell migration. Podosomes present as micron-sized F-actin cores surrounded by an adhesive ring of integrins and integrin–actin linkers, such as talin and vinculin. In this Review, we highlight...