... easy and precise visualization of the transcriptional activity of endogenous p53. p53 Cell biology Transcription factor Cell cycle Cell death Fluorescent reporter system Japan Society for the Promotion of Science http://dx.doi.org/10.13039/501100001691 20H02873...

... eventually leading to neuronal loss. Although the glial activation mechanism in AD has been relatively well studied, how it perturbs intraneuronal signaling, which ultimately leads to neuronal cell death, remains poorly understood. Here, we report that compound stimulation with the neurotoxic factors TNF...

...Sandy B. Serizier; Jeanne S. Peterson; Kimberly McCall ABSTRACT The last step of cell death is cell clearance, a process critical for tissue homeostasis. For efficient cell clearance to occur, phagocytes and dead cells need to reciprocally signal to each other. One important phenomenon...

.... Mechanistically, VRB and cortisone signaled through the integrated stress response mediated by eIF2α (also known as EIF2S1), yet induced different kinases, with cortisone activating the GCN2 kinase (also known as EIF2AK4). Cortisone increased VRB-induced cell death and reduced the population of cells trapped...

...Adi Zheng; Gilles Dubuis; Maria Georgieva; Carla Susana Mendes Ferreira; Marc Serulla; Maria del Carmen Conde Rubio; Evgeniya Trofimenko; Thomas Mercier; Laurent Decosterd; Christian Widmann ABSTRACT High-density lipoproteins (HDLs) prevent cell death induced by a variety of cytotoxic drugs...

... software (Zeiss). Cell divisions and the time from Fc-scTRAIL addition to apoptotic cell death were analysed in parallel. For pH2A.X staining, cells grown on coverslips were treated for 24 h, dead cells were removed by washing, and surviving cells were fixed, permeabilised and immunostained for pH2A.X...

... (OPTN) to ubiquitylated lysosomes. In addition, we observed that LC3 (MAP1LC3B) recruitment to damaged lysosomes was dependent on TBK1 activity. In these fibrillar AS-treated cells, autophagy inhibition impairs mitochondrial function and leads to microglial cell death. Our results suggest...

... chronic stress in a human cell line and mouse embryonic fibroblasts. Surprisingly, we found that SGs that form under chronic nutrient starvation lack 40S ribosomes, do not actively exchange their constituent components with cytoplasmic pools and promote cell death. We named these SGs starvation-induced...

...Shani Bialik; Santosh K. Dasari; Adi Kimchi ABSTRACT Autophagy as a means of cell killing was first advanced by Clark's phenotypic description of ‘Type II autophagic cell death’ in 1990. However, this phenomenon later came into question, because the presence of autophagosomes in dying cells does...

... to a particular form of cell death called pyroptosis. Mutations in genes that encode inflammasome components are associated with many inflammatory disorders, and studies in the past decade have highlighted the importance of appropriate activation of the inflammasome in homeostasis and disease pathogenesis...

..., the γH2Av response has also been reported in dying cells, where it requires activation of caspase-activated DNases (CADs). Moreover, caspases are known to be required downstream of DNA damage for cell death execution. We show here, for the first time, that the Drosophila initiator caspase Dronc acts...

...Ying Hou; Lindsey A. Allan; Paul R. Clarke ABSTRACT Regulation of cell death is crucial for the response of cancer cells to drug treatments that cause arrest in mitosis, and is likely to be important for protection against chromosome instability in normal cells. Prolonged mitotic arrest can result...

... bacterial aggregates are formed that can be extruded out of the tissue after cell death. Alternatively, these excessively infected cells can undergo necrosis leading to immediate recruitment of surrounding leukocytes and subsequent phagocytosis of released bacteria. Our data show that these necrotic burst...

... colony formation and tumor growth in xenograft assays in a PP1-dependent manner. Our data show that the selective inhibition of PP1 can be used to induce cancer cell death through mitotic catastrophe. The mitotic-arrest phenotypes were generally somewhat stronger for NIPP1-Wt than for NIPP1-Fm. Indeed...

..., we report that p75 NTR signals very differently in hippocampal neurons (HCNs) and cerebellar granule neurons (CGNs), and we present evidence indicating that this is partly controlled by differential proteolytic cleavage. Nerve growth factor (NGF) induced caspase‐3 activity and cell death in HCNs...

... death.   Brain   134 , 1658 – 1672 . 10.1093/brain/awr104 Alano   C. C. , Ying   W. , Swanson   R. A. ( 2004 ). Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD + depletion and mitochondrial permeability transition.   J. Biol. Chem.   279 , 18895 – 18902...

...A. Pedro Gonçalves; J. Miguel Cordeiro; João Monteiro; Alberto Muñoz; Paulo Correia-de-Sá; Nick D. Read; Arnaldo Videira ABSTRACT The model organism Neurospora crassa undergoes programmed cell death when exposed to staurosporine. Here, we show that staurosporine causes defined changes in cytosolic...

.... , Frasch   S. C. , Warner   M. L. , Henson   P. M. ( 1998 ). The role of phosphatidylserine in recognition of apoptotic cells by phagocytes.   Cell Death Differ.   5 , 551 – 562 . 10.1038/sj.cdd.4400404 Farhadifar   R. , Röper   J. C. , Aigouy   B. , Eaton   S. , Jülicher...

... of both RB and TSC2 induces synergistic apoptosis during the development of Drosophila melanogaster and in cancer cells. However, the in vivo mechanism of this synthetic-lethal interaction is not clear. Here, we show that synergistic cell death in tissues that have lost the RB and TSC orthologs rbf...

... for correspondence ( adi.kimchi@weizmann.ac.il ) © 2012. Published by The Company of Biologists Ltd 2012 Apoptosis Autophagy Cancer Cell death Crosstalk The evolutionary transition to multicellularity has dictated the emergence of a highly controlled genetic program of cellular suicide, known...