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Keywords: Cell cycle
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Journal Articles
J Cell Sci (2023) 136 (1): jcs260279.
Published: 3 January 2023
...Ana Cláudia Leite; Telma S. Martins; Rute R. Cesário; Vitor Teixeira; Vítor Costa; Clara Pereira ABSTRACT Cdc28, the homolog of mammalian Cdk1, is a conserved key regulatory kinase for all major cell cycle transitions in yeast. We have found that defects in mitochondrial respiration (including...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (16): jcs259996.
Published: 18 August 2022
... stopped, and cells with giant lipid droplets were arrested in G1 phase. We investigated whether cell cycle arrest at a specific phase is required for lipid accumulation. Lipid accumulation was repressed in hydroxyurea-synchronized S phase cells and was increased in nocodazole-arrested G2/M phase cells...
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (14): jcs260015.
Published: 20 July 2022
... of the centriole cartwheel at the proximal end. CP110 Cep97 Polo-like kinase 4 Centriole Centrosome Organelle biogenesis Cell cycle Embryogenesis Wellcome Trust http://dx.doi.org/10.13039/100010269 104575 215523 Edward Penley Abraham Scholarship Sandler Foundation...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (10): jcs244004.
Published: 24 May 2022
.... Understanding and accounting for these cell-cycle-dependent conformational changes is essential for the interpretation of data from a growing array of powerful molecular techniques to investigate genome conformation function, and to identify the molecules and mechanisms that drive chromosome conformational...
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2022) 135 (8): jcs259120.
Published: 21 April 2022
... of distal and subdistal appendages one-and-a-half cell cycles later, as they exit their second mitosis. Current models postulate that the centriolar protein centrobin acts as placeholder for distal appendage proteins that must be removed to complete distal appendage formation. Here, we investigated, in non...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2022) 135 (3): jcs258745.
Published: 2 February 2022
... http://dx.doi.org/10.13039/100000057 5R35GM126980 Cell cycle Chromosome Fluorescence Microtubules Mitosis Mitotic spindle Highlighted Article: In contrast to the current paradigm, fluorescence dissipation experiments reveal that mitotic spindles contain multiple populations...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (21): jcs258948.
Published: 10 November 2021
... offers unique advantages for investigating organellar proliferation and the cell cycle. Here, we describe CZON-cutter, an engineered clustered, regularly interspaced, short palindromic repeats (CRISPR)/CRISPR-associated nuclease 9 (Cas9) system for simultaneous genome editing and organellar visualization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (20): jcs253807.
Published: 21 October 2021
...Yi Xin; Jian Guan; Yingxiang Li; Cunming Duan ABSTRACT Compared with our extensive understanding of the cell cycle, we have limited knowledge of how the cell quiescence–proliferation decision is regulated. Using a zebrafish epithelial model, we report a novel signaling mechanism governing the cell...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (19): jcs259291.
Published: 11 October 2021
... Highlighted Article: Resumption of polarized Cdc42 activation at growth sites depends on a cell-cycle cue. This is facilitated by the loss of a Cdc42 GAP, Rga4, from growth sites at the end of cell division. Cdc42 Rga4 Cell cycle Cell growth Cytokinesis Polarization National Institute...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs258341.
Published: 4 August 2021
... components with the pathway that regulates the response to osmotic stress (HOG). Here, we show that the two pathways exhibit different patterns of activity throughout the cell cycle. The different patterns resulted from different expression profiles of genes encoding mucin sensors that regulate the pathways...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2021) 134 (9): jcs253450.
Published: 11 May 2021
... starting from postnatal day (P)14. However, abnormal MCC differentiation in the dKO EDs could be observed as early as P7. RNA-seq analyses revealed that the aberrant development of MCCs in the EDs of dKO mice was associated with the upregulation of genes involved in cell cycle control. Using a cyclin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (24): jcs251413.
Published: 21 December 2020
...Ester Méndez; Mercè Gomar-Alba; M. Carmen Bañó; Manuel Mendoza; Inma Quilis; J. Carlos Igual ABSTRACT Start is the main decision point in the eukaryotic cell cycle at which cells commit to a new round of cell division. It involves the irreversible activation of a transcriptional programme through...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (5): jcs252544.
Published: 9 November 2020
... and, in accordance, individual genomes exhibited heterogeneous replication activity. By analyzing the cell cycle state, we found that G1 cells exhibited the highest E1A gene expression and displayed increased correlation between E1A gene expression and viral genome copy numbers. The combined image-based single...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs246330.
Published: 24 June 2020
... in situ hybridization (FISH) with single-molecule RNA FISH (smFISH) and immunofluorescence to study nuclear architecture-dependent gene regulation on a cell-by-cell basis. We further combine our method with imaging-based cell cycle staging to correlate nuclear architecture with gene expression across...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (12): jcs240721.
Published: 18 June 2020
... and HChs favors growth arrest suggests that rather than specific permeants mediating cell cycle arrest, the closed conformation instead supports interaction of Cx37 with growth regulatory proteins that result in growth arrest. * Author for correspondence ( jburt@u.arizona.edu ) Handling Editor...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs245043.
Published: 1 June 2020
...Björn Eismann; Teresa G. Krieger; Jürgen Beneke; Ruben Bulkescher; Lukas Adam; Holger Erfle; Carl Herrmann; Roland Eils; Christian Conrad ABSTRACT 3D cell cultures enable the in vitro study of dynamic biological processes such as the cell cycle, but their use in high-throughput screens remains...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (10): jcs239723.
Published: 27 May 2020
...-licence-1-1/ Summary: CSAG1, a novel regulator of mitosis that constrains the pericentriolar material to prevent spindle pole fragmentation, particularly, in cells that lack p53 function. Cell cycle Spindle pole Multipolar mitosis Aneuploidy Pericentriolar matrix Mitosis...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (8): jcs240978.
Published: 29 April 2020
.... Summary: Trypanosomes lack a canonical spindle checkpoint system, but kinetochore kinases KKT10/19 phosphorylate KKT4 and KKT7 and are important for promoting the metaphase to anaphase transition in T. brucei. Kinetoplastid kinetochore Trypanosoma brucei Kinase KKT Cell cycle Proper...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (7): jcs240986.
Published: 6 April 2020
...Maciej Jerzy Smialek; Bogna Kuczynska; Erkut Ilaslan; Damian Mikolaj Janecki; Marcin Piotr Sajek; Kamila Kusz-Zamelczyk; Jadwiga Jaruzelska ABSTRACT Regulation of proliferation, apoptosis and cell cycle is crucial for the physiology of germ cells. Their malfunction contributes to infertility...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (6): jcs235721.
Published: 17 March 2020
...Yang Ma; Guanxiong Yan; Xiaojie Han; Jing Zhang; Jie Xiong; Wei Miao ABSTRACT To investigate the mechanisms underlying initiation of the sexual cell cycle in eukaryotes, we have focused on cyclins and cyclin-dependent kinases (CDKs) in the well-studied model ciliate, Tetrahymena thermophila . We...
Includes: Supplementary data