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Keywords: Cdc42
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Journal Articles
In collection:
Polarity
J Cell Sci (2023) 136 (2): jcs259639.
Published: 24 January 2023
.... ( 2017 ). Many roads to symmetry breaking: molecular mechanisms and theoretical models of yeast cell polarity . Mol. Biol. Cell 28 , 370 - 380 . 10.1091/mbc.e16-10-0739 Goryachev , A. B. and Pokhilko , A. V. ( 2008 ). Dynamics of Cdc42 network embodies a Turing-type mechanism...
Journal Articles
J Cell Sci (2022) 135 (16): jcs259912.
Published: 18 August 2022
... the stereocilia of cochlear hair cells and cooperates with CDC42 to regulate F-actin polymerization and cell protrusion formation in cultured COS-7 cells. In the present work, Fchsd2 knockout mice were established to investigate the role of FCHSD2 in hearing. Our data show that stereocilia maintenance is severely...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (15): jcs260364.
Published: 16 August 2022
... by Nckap1l ) followed by serum and growth factor stimulation, or active GTPase expression, revealed a pathway to formation of Arp2/3 complex-dependent lamellipodia-like structures (LLS) that requires both Rac and Cdc42 GTPases, but not WRC. These phenotypes were independent of the WRC subunit eliminated...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (19): jcs259291.
Published: 11 October 2021
... uncoupled these sequential events by delaying cytokinesis with a temporary Latrunculin A treatment. Mitotic cells recovering from treatment initiate end growth during septation, displaying a polar elongation simultaneous with septation (PrESS) phenotype. PrESS cell ends reactivate Cdc42, a major regulator...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs240135.
Published: 10 August 2021
... depletion in tumour cells caused redistribution of the actin cytoskeleton and increased activity of the Rho GTPase CDC42, known for its role in actin remodelling and cell migration. In a xenograft model of breast cancer, tumour cell CD99 expression inhibited metastatic progression, and patient samples...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (11): jcs240283.
Published: 11 June 2020
... in a complex assembly pathway that culminates in the outgrowth of a new daughter cell. During recruitment, septin rods follow the high concentration of Cdc42 GTP that is generated by the focused localization of the Cdc42 guanine-nucleotide-exchange factor Cdc24. We show that, shortly before budding, Cdc24...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (5): jcs238337.
Published: 13 March 2020
..., a previously undescribed polybasic motif that is strictly conserved in Vav1 and absent from Vav2 in tetrapods. Conversely, the catalytic activity of Vav2 contributes to the suppression of TCR-mediated Ca 2+ entry. By performing an in vivo ‘ GEF trapping’ assay in intact cells, we demonstrate that Cdc42...
Includes: Supplementary data
Journal Articles
J Cell Sci (2020) 133 (3): jcs237982.
Published: 13 February 2020
...: The vesicle-tethering and fusion factors Boi1 and Boi2 are shown to initiate the formation of actin filaments by recruiting the Bni1–Bud6 actin nucleation complex to sites of exocytosis. Polar growth Vesicular traffic Actin nucleation Cdc42 Split-Ubiquitin Yeast The directed transport...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2019) 132 (24): jcs230995.
Published: 13 December 2019
... highlight how intracellular organelles and their associated trafficking routes provide diverse feedback for dynamic cell polarity maintenance. We argue that the asymmetric organelle compass is an indispensable element of the polarity network. Cdc42 Actin Intracellular organization Organelle Polarity...
Journal Articles
J Cell Sci (2019) 132 (23): jcs236018.
Published: 3 December 2019
...Brian S. Hercyk; Julie Rich-Robinson; Ahmad S. Mitoubsi; Marcus A. Harrell; Maitreyi E. Das ABSTRACT Cdc42, a conserved regulator of cell polarity, is activated by two GEFs, Gef1 and Scd1, in fission yeast. Why the cell needs two GEFs is unclear, given that they are partially redundant and activate...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (11): jcs230706.
Published: 31 May 2019
... on chemoattractant gradient detection in yeast, which occurs at a motile polarity patch. It further describes the stabilization and hyperpolarization process underlying cell fusion. Cell fusion Cell polarity Chemotropism Pheromone gradient Cdc42 MAPK S. cerevisiae S. pombe All cells...
Journal Articles
J Cell Sci (2019) 132 (10): jcs217869.
Published: 21 May 2019
...Franck Pichaud; Rhian F. Walther; Francisca Nunes de Almeida ABSTRACT Cdc42 – a member of the small Rho GTPase family – regulates cell polarity across organisms from yeast to humans. It is an essential regulator of polarized morphogenesis in epithelial cells, through coordination of apical membrane...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2019) 132 (8): jcs223743.
Published: 25 April 2019
... formation. Binding is conferred by a FERM/FA domain–kinase domain interaction and detachment promoted by aPKCι-dependent phosphorylation. FARP2 is shown to promote GTP loading of Cdc42, which is consistent with it being involved in upstream regulation of the polarising PAR6–aPKCι complex. However, we show...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (4): jcs217554.
Published: 30 January 2019
...–diffusion and cytoskeleton-based mechanisms interact. We use polarity establishment in budding yeast as an example. Polarity establishment in budding yeast is a classical system for pattern formation ( Bi and Park, 2012 ; Martin, 2015 ) ( Fig. 4 A), where a Cdc42-based protein pattern on the cell...
Includes: Supplementary data
Journal Articles
J Cell Sci (2018) 131 (15): jcs217091.
Published: 3 August 2018
...). The formation of MSCRs was also induced by the continuous depolarization of the actin cytoskeleton caused by a treatment with latrunculin-A, an effective inhibitor of actin polymerization. Unlike the formation of conventional septin rings, the formation of MSCRs did not require Cdc42 and its effectors, Gic1...
Journal Articles
In collection:
Polarity
J Cell Sci (2018) 131 (14): jcs216580.
Published: 19 July 2018
...Ye Dee Tay; Marcin Leda; Andrew B. Goryachev; Kenneth E. Sawin ABSTRACT The conserved Rho-family GTPase Cdc42 plays a central role in eukaryotic cell polarity. The rod-shaped fission yeast Schizosaccharomyces pombe has two Cdc42 guanine nucleotide exchange factors (GEFs), Scd1 and Gef1, but little...
Includes: Supplementary data
Journal Articles
In collection:
Cell Migration
J Cell Sci (2017) 130 (18): 2971–2983.
Published: 15 September 2017
... to these processes are complex. Here, we modify the activity of the two Rho GTPase family members Rac and Cdc42 by optogenetically recruiting specific guanine nucleotide exchange factor (GEF) DH or PH domains to defined regions of the cell membrane. We find that the localized activation of both GTPases produces...
Includes: Supplementary data
Journal Articles
J Cell Sci (2016) 129 (2): 380–393.
Published: 15 January 2016
... cancer, was recently reported to localize to cell–cell adhesions and to drive epithelial cell colony escape. Here we report that PAK6 targeting to cell–cell adhesions occurs through its N-terminus, requiring both its Cdc42/Rac interactive binding (CRIB) domain and an adjacent polybasic region for maximal...
Journal Articles
J Cell Sci (2015) 128 (22): 4183–4195.
Published: 15 November 2015
... describe how a direct interaction between the Rho GTPase Cdc42 and the GTPase-activating protein (GAP) GRAF1 (also known as ARHGAP26), facilitates rapid cell surface turnover at the leading edge. Both Cdc42 and GRAF1 were required for fluid-phase uptake and regulated the generation of transient GRAF1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (15): 2866–2880.
Published: 1 August 2015
...) as well as its downstream effector Cdc42 is upregulated in dendritic cells upon maturation. Although dendritic cell maturation was independent of 5-HT 7 R, receptor stimulation affected dendritic cell morphology through Cdc42-mediated signaling. In addition, basal activity of 5-HT 7 R was required...
Includes: Supplementary data