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Keywords: Calpain
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Journal Articles
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Cytoskeleton
J Cell Sci (2022) 135 (9): jcs259108.
Published: 6 May 2022
... the regulation of detyrosination. Here, we found that intracellular Ca 2+ is required for efficient MT detyrosination. Furthermore, we show that the Ca 2+ -dependent proteases calpains 1 and 2 (CAPN1 and CAPN2, respectively) regulate MT detyrosination in VASH1- and SVBP-overexpressing human embryonic kidney...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (19): 4134–4145.
Published: 1 October 2014
... involving calpain-mediated activation of Bax and mitochondrial release of apoptosis-inducing factor (AIF). However, whether these two mechanisms represent distinct pathways for PARP1-induced necrosis, or whether they are simply different components of the same pathway has yet to be tested. Mouse embryonic...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2010) 123 (1): 51–61.
Published: 1 January 2010
... of Fam38A in epithelial cells inactivates endogenous β1 integrin, reducing cell adhesion. Fam38A mediates integrin activation by recruiting the small GTPase R-Ras to the ER, which activates the calcium-activated protease calpain by increasing Ca 2+ release from cytoplasmic stores. Fam38A-induced integrin...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2008) 121 (23): 3951–3959.
Published: 1 December 2008
...Magali Louis; Nadège Zanou; Monique Van Schoor; Philippe Gailly Myoblast migration is a key step in myogenesis and regeneration. It allows myoblast alignment and their fusion into myotubes. The process has been shown to involve m-calpain or μ-calpain, two Ca 2+ -dependent cysteine proteases. Here...
Journal Articles
J Cell Sci (2008) 121 (21): 3581–3588.
Published: 1 November 2008
... place. Members of the calpain family of calcium-dependent proteases are believed to have a central role in these processes, possibly through the regulation of focal adhesion dynamics. The ubiquitous calpains, calpain 1 (μ-calpain) and calpain 2 (m-calpain), are heterodimers consisting of large catalytic...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (11): 2375–2385.
Published: 1 June 2006
... and the mechanisms that regulate their high turnover are unknown at present. The cysteine protease calpain is involved in the regulation of cell migration in part by promoting either formation or disassembly of adhesion sites. Despite the fact that many known substrates of calpain are also structural components...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2005) 118 (17): 3829–3838.
Published: 1 September 2005
...Santos J. Franco; Anna Huttenlocher The calpain family of proteases has been implicated in cellular processes such as apoptosis, proliferation and cell migration. Calpains are involved in several key aspects of migration, including: adhesion and spreading; detachment of the rear; integrin...
Journal Articles
Journal Articles
J Cell Sci (2004) 117 (8): 1329–1337.
Published: 15 March 2004
... in the pulmonary epithelium of foxj1 +/+ and foxj1 -/- mice. In the absence of Foxj1, the expression of calpastatin, an inhibitor of the protease calpain, decreased. RNase protection confirmed the decrease in calpastatin expression and decreased calpastatin was detected in the proximal pulmonary epithelium...
Journal Articles
J Cell Sci (2002) 115 (17): 3415–3425.
Published: 1 September 2002
...Amit Bhatt; Irina Kaverina; Carol Otey; Anna Huttenlocher Cell migration requires the regulated and dynamic turnover of adhesive complexes. We have previously demonstrated that the calcium-dependent protease, calpain, regulates the organization of adhesive complexes and cell detachment during cell...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (1998) 111 (7): 929–940.
Published: 1 April 1998
.... In the adhesive regime where rear detachment limits the rate of cell migration, cell speed has an inverse relationship to the amount of integrin released at the rear of the cell. At high cell-substratum adhesiveness, calpain, a Ca 2+ -dependent protease, is also involved in release of cytoskeletal linkages during...
Journal Articles
Journal Articles
J Cell Sci (1993) 105 (3): 787–798.
Published: 1 July 1993
...Sassan M. Azarian; Cassandra L. Schlamp; David S. Williams ABSTRACT Calpain II was purified to apparent homogeneity from bovine neural retinas. It was found to be biochemically similar to brain calpain II, purified by the same procedure, with respect to: subunit mobility in SDS-polyacrylamide gel...