... is regulated. Whole-transcriptome sequencing revealed that CSF-1-stimulated differentiation of bone marrow-derived precursors into mature macrophages is accompanied by widespread, profound changes in the expression of genes regulating adhesion, actin cytoskeletal remodeling and extracellular matrix degradation...

... factor 1 (CSF-1) and receptor activator of NF-κB ligand (RANKL; also known as tumor necrosis factor ligand superfamily member 11, Tnsf11). RANKL-deficient (RANKL −/− ) mice and Fos −/− mice exhibit osteopetrosis due to an osteoclast deficiency. We previously reported that RANK-positive osteoclast...

...Martine F. Roussel SUMMARY The macrophage-specific colony-stimulating factor 1(CSF-1 or M-CSF) is required throughout the G 1 phase of the cell cycle to regulate both immediate and delayed early responses necessary for cell proliferation. These are triggered by the binding of the growth factor...