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Keywords: CRAC
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Journal Articles
J Cell Sci (2020) 133 (8): jcs239491.
Published: 29 April 2020
... reticulum and Ca 2+ release-activated channel (CRAC) Orai on the plasma membrane. However, the molecular details of their interactions remain elusive. Here, we analyzed STIM1-Orai interactions using synthetic peptides derived from the N- and C-termini of Orai channels (Orai-NT and Orai-CT, respectively...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (2): 287–294.
Published: 15 January 2012
... causes muscle weakness ( Gwack et al., 2008 ; Vig et al., 2008 ) and perinatal death, probably from myopathy. Mice lacking STIM1, the calcium sensor of the endoplasmic and sarcoplasmic reticulum required to activate ORAI1, also develop skeletal myopathy and severe immunodeficiency, suggesting that CRAC...
Includes: Multimedia, Supplementary data