... delays Brefeldin-A-induced Golgi-to-ER retrograde transport, phenocopying cells with mutations or silencing of the conserved oligomeric Golgi (COG) complex. Co-immunoprecipitation and in vitro binding experiments reveals that TMEM115 interacts with the COG complex, and might self-interact to form dimers...

... that the large coiled-coil proteins are anchored at one end to a membrane, which allows them to `search'the surrounding space for a passing vesicle, which is then bound by the other end. Although this is an attractive model, there is currently a lack of direct evidence for it. The COG complex has been...