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Keywords: Basement membrane
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Journal Articles
In collection:
Cell Cycle , Polarity
J Cell Sci (2023) 136 (19): jcs261178.
Published: 11 October 2023
... player, underlies the laminin-rich ECM-induced cell cycle arrest that is crucial for mammary gland development, architecture and function. Pten Basement membrane Cell cycle Extracellular matrix Mammary gland acinogenesis Quiescence Fundação de Amparo à Pesquisa do Estado de São Paulo...
Includes: Supplementary data
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In collection:
Adhesion
J Cell Sci (2022) 135 (23): jcs260232.
Published: 5 December 2022
... to laminin α5-containing basement membrane matrix, which is produced by luminal cells, presents such a control mechanism. Adhesion to laminin α5 directs basal cells towards a luminal cell fate, and thereby results in a marked decrease of basal MEC progenitor activity in vitro and in vivo . Mechanistically...
Includes: Supplementary data
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J Cell Sci (2020) 133 (18): jcs239889.
Published: 16 September 2020
...Claire Leclech; Carlo F. Natale; Abdul I. Barakat ABSTRACT The basement membrane (BM) is a thin specialized extracellular matrix that functions as a cellular anchorage site, a physical barrier and a signaling hub. While the literature on the biochemical composition and biological activity of the BM...
Includes: Supplementary data
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Journal Articles
J Cell Sci (2017) 130 (19): 3203–3211.
Published: 1 October 2017
... signals that pattern the surrounding tissues. It is composed of a core of vacuolated cells surrounded by an epithelial-like sheath of cells that secrete a thick peri-notochordal basement membrane made of different extracellular matrix (ECM) proteins. The correct deposition and organization of the ECM...
Journal Articles
J Cell Sci (2016) 129 (13): 2586–2598.
Published: 1 July 2016
... known as MMP14) cell surface exposure at podosome sites. We hypothesise that by promoting podosome formation, VEGF-A enables endothelial cells to overcome the basement membrane barrier to allow sprouting outwards from the existing vasculature. * Present address: Department of Biomedecine...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (15): 3217–3225.
Published: 1 August 2014
... inside-out signals to polarise basement membrane assembly at the basal surface, and outside-in signals to control microtubule apical–basal orientation and vesicular trafficking are required for establishing and maintaining the orientation of epithelial cell polarity. Finally, we discuss the relevance...
Journal Articles
J Cell Sci (2012) 125 (19): 4609–4619.
Published: 1 October 2012
...Karen K. McKee; Dong-Hua Yang; Rajesh Patel; Zu-Lin Chen; Sidney Strickland; Junichi Takagi; Kiyotoshi Sekiguchi; Peter D. Yurchenco Summary Laminins promote early stages of peripheral nerve myelination by assembling basement membranes (BMs) on Schwann cell surfaces, leading to activation of β1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (18): 4241–4252.
Published: 15 September 2012
... and differentiate to form a stratified epithelium. Using a comparative proteomic approach, we studied this ‘confluence switch’ and identified a new pathway triggered by cell confluence that regulates basement membrane (BM) protein composition by suppressing the uPA–uPAR–plasmin pathway. Indeed, confluence triggers...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (17): 2927–2937.
Published: 1 September 2011
... are heterotrimeric glycoproteins of the extracellular matrix that are secreted by epithelial cells and which are crucial for the normal structure and function of the basement membrane. We have generated a mouse harboring a conditional knockout of α3 laminin ( Lama3 fl/fl ), one of the main laminin subunits...
Includes: Supplementary data
Journal Articles
J Cell Sci (2008) 121 (15): 2493–2502.
Published: 1 August 2008
.... The colon also contains crypts of Lieberkühn, but its epithelial surface is lined by flat surface cuffs. The epithelial cells of both organs communicate with the underlying mesenchyme through a basement membrane that is composed of a variety of extracellular matrix proteins, including members...
Includes: Supplementary data
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J Cell Sci (2004) 117 (24): 5913–5922.
Published: 15 November 2004
..., but not of laminin and nidogen-1, in the basement membrane (BM). Electron immunomicroscopy revealed accumulation of type IV collagen in dilated ERs, but not in the BM of Hsp47 –/– embryos, whereas it was only present in the BM in Hsp47 +/+ embryos. The BM structures stained with anti-laminin and anti-nidogen-1...
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J Cell Sci (2003) 116 (14): 2975–2986.
Published: 15 July 2003
... cells were placed on tissue culture plastic; however, the presence of a reconstituted basement membrane in combination with lactogenic hormones partially prevented this decrease. Estrogen receptor αexpression in primary mammary fibroblasts was not altered by these culture conditions, indicating that its...