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Keywords: Basal body
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Journal Articles
J Cell Sci (2022) 135 (17): jcs259444.
Published: 8 September 2022
... in ciliary cell biology. Basal body Centrosome Cilia Cytoplasmic transport Diffusion Motor proteins National Heart, Lung, and Blood Institute https://doi.org/10.13039/100000050 R01HL117164 Eunice Kennedy Shriver National Institute of Child Health and Human Development https...
Journal Articles
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In collection:
Cilia and Flagella
J Cell Sci (2022) 135 (6): jcs259201.
Published: 16 March 2022
.... Ezrin, a crosslinker between membrane proteins and the actin cytoskeleton, is located in microvilli and around the basal bodies in airway ciliary cells. It is also likely that ezrin plays an important role in apical localization of β 2 adrenergic receptor (β 2 AR) in airway ciliary cells. Here, we...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (4): jcs257006.
Published: 22 February 2021
..., MCCs exhibit a characteristic basal body (BB) orientation and microtubule gradient along the tissue axis. The intracellular polarities were moderately maintained in cells lacking CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1), a planar cell polarity (PCP) factor involved in tissue polarity...
Includes: Supplementary data
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In collection:
Cytoskeleton
J Cell Sci (2019) 132 (3): jcs226951.
Published: 7 February 2019
... code Sperm development Tubulin post-translational modifications Axoneme Basal body Sexual reproduction in mammals involves two highly different types of gametes, the oocyte and the spermatozoon. Sperm cells are considered the most-differentiated mammalian cells, and are constantly generated...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (20): jcs220905.
Published: 26 October 2018
... and a secondary screen of these strains for ones that fail to localize NPHP4 properly. We identified four mutant strains, called IB4, DB35, GB10 and GB24, that lack NPHP4 at the basal bodies by immunofluorescence analysis of cell expressing a HA::NPHP4 transgene ( Awata et al., 2014 ) ( Fig. 1 A). Although we...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (16): jcs218297.
Published: 17 August 2018
...-licence-1-1/ Summary: The membrane phospholipid PIP 2 , and the kinase that produces PIP 2 , called Skittles, are needed for normal ciliary transition zone morphology and function in the Drosophila male germline. PtdIns(4,5)P 2 Skittles Cep290 Cilia Transition zone Basal body...
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2017) 130 (9): 1662–1674.
Published: 1 May 2017
... proteins accumulate at basal bodies. However, little is known about the molecular mechanism of basal body targeting of IFT proteins. We first identified the possible basal body-targeting sequence in IFT46 by expressing IFT46 truncation constructs in an ift46-1 mutant. The C-terminal sequence between...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2016) 129 (3): 621–636.
Published: 1 February 2016
...–Cep97 binding to the basal body is the only cause for the cilia assembly defect in WDR8-depleted RPE-1 cells. To test this hypothesis, we ectopically downregulated CP110 in cells lacking WDR8 ( Fig. 4 D). The combined treatment of cells with WDR8 and CP110 siRNAs led to a substantial reduction in CP110...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1294–1307.
Published: 1 April 2015
... to identify a centriole, basal body or axoneme-targeting domain, the localization of MAP6–GFP, hSAXO1–GFP and hSAXO1–GFP truncations was analyzed in transfected RPE1 cells incubated in low-serum medium for 24 h to induce ciliogenesis ( Fig. 7 ). We show that MAP6–GFP localized throughout the cytoplasm...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2803–2810.
Published: 1 July 2014
...Chad G. Pearson ABSTRACT Centrioles and basal bodies (CBBs) are microtubule-rich cylindrical structures that nucleate and organize centrosomes and cilia, respectively. Despite their apparent ninefold rotational symmetry, the nine sets of triplet microtubules in CBBs possess asymmetries...
Journal Articles
J Cell Sci (2014) 127 (11): 2407–2419.
Published: 1 June 2014
...Carmen C. Leitch; Sukanya Lodh; Victoria Prieto-Echagüe; Jose L. Badano; Norann A. Zaghloul ABSTRACT Proteins associated with primary cilia and basal bodies mediate numerous signaling pathways, but little is known about their role in Notch signaling. Here, we report that loss of the Bardet-Biedl...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2012) 125 (13): 3173–3184.
Published: 1 July 2012
... duplication of a centrin-containing cytoskeletal structure known as the bilobe. We show that TbPLK has a dynamic localization pattern during the cell cycle. The kinase localizes to the basal body, which nucleates the flagellum, and then successively localizes to a series of cytoskeletal structures...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (17): 2964–2975.
Published: 1 September 2011
... and Xho I. The combined insert was used as the full-length cDNA of CRC70. * Author for correspondence ( hirono@biol.s.u-tokyo.ac.jp ) 17 5 2011 © 2011. 2011 Centriole Basal body Cartwheel SAS-6 bld10 bld12 The centriole is a cellular organelle that functions...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2539–2551.
Published: 1 August 2011
.... Electron microscopy and live imaging showed that cells lacking EB1 or EB3 are defective in MT minus-end anchoring at the centrosome and/or basal body, and possess abnormally short cilia stumps surrounded by vesicles. Further, GST pull-down assays, mass spectrometry and immunoprecipitation indicated...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2622–2630.
Published: 1 August 2011
...Lina Ma; Andrew P. Jarman A significant number of ciliary disease genes have been found to encode proteins that localise to the basal body. By contrast, a large number of basal-body-associated proteins remain to be characterised. Here, we report the identification of a new basal body protein...
Includes: Multimedia, Supplementary data