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Keywords: Basal body
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Journal Articles
J Cell Sci (2022) 135 (17): jcs259444.
Published: 8 September 2022
... in ciliary cell biology. Basal body Centrosome Cilia Cytoplasmic transport Diffusion Motor proteins National Heart, Lung, and Blood Institute https://doi.org/10.13039/100000050 R01HL117164 Eunice Kennedy Shriver National Institute of Child Health and Human Development https...
Journal Articles
J Cell Sci (2022) 135 (11): jcs259893.
Published: 9 June 2022
... that TFK1 is a newly identified basal body maturation marker. Furthermore, using ultrastructure expansion and immuno-electron microscopies we localized CEP164C and TbRP2 at the TF, and TFK1 on the distal appendage matrix of the TF. Importantly, RNAi-mediated knockdown of TFK1 in bloodstream form cells...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2022) 135 (6): jcs259201.
Published: 16 March 2022
.... Ezrin, a crosslinker between membrane proteins and the actin cytoskeleton, is located in microvilli and around the basal bodies in airway ciliary cells. It is also likely that ezrin plays an important role in apical localization of β 2 adrenergic receptor (β 2 AR) in airway ciliary cells. Here, we...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (4): jcs257006.
Published: 22 February 2021
..., MCCs exhibit a characteristic basal body (BB) orientation and microtubule gradient along the tissue axis. The intracellular polarities were moderately maintained in cells lacking CELSR1 (cadherin EGF LAG seven-pass G-type receptor 1), a planar cell polarity (PCP) factor involved in tissue polarity...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2020) 133 (11): jcs240838.
Published: 4 June 2020
...Westley Heydeck; Brian A. Bayless; Alexander J. Stemm-Wolf; Eileen T. O'Toole; Amy S. Fabritius; Courtney Ozzello; Marina Nguyen; Mark Winey ABSTRACT Basal bodies (BBs) are microtubule-based organelles that act as a template for and stabilize cilia at the cell surface. Centrins ubiquitously...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2019) 132 (5): jcs222331.
Published: 15 February 2019
... movements, indicating miscoordination in IFT complex trafficking. Within the OSN dendritic knob, the basal bodies are dynamic, with incorporation of ectopically expressed centrin-2 and γ-tubulin occurring after nascent ciliogenesis. Importantly, BBS4 loss results in the reduction of basal body numbers...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2019) 132 (3): jcs226951.
Published: 7 February 2019
... of basal bodies ( Fig. 4 C), we counted γ-tubulin-positive spots in dissociated testicular cells. Only those spermatids that had condensing nuclei and that were positive for the acrosome staining (anti-sp56 antibody) were used for quantification. We distinguished three different categories: 1–2 basal...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (20): jcs220905.
Published: 26 October 2018
... provided that the original work is properly attributed. Summary: RPGRIP1L, a key protein of the transition zone that is needed for NPHP4 localization, helps to exclude cytoplasmic proteins from the cilia in Chlamydomonas reinhardtii . Transition zone Cilia Basal body Chlamydomonas...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2018) 131 (16): jcs218297.
Published: 17 August 2018
...-licence-1-1/ Summary: The membrane phospholipid PIP 2 , and the kinase that produces PIP 2 , called Skittles, are needed for normal ciliary transition zone morphology and function in the Drosophila male germline. PtdIns(4,5)P 2 Skittles Cep290 Cilia Transition zone Basal body...
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2017) 130 (9): 1662–1674.
Published: 1 May 2017
... proteins accumulate at basal bodies. However, little is known about the molecular mechanism of basal body targeting of IFT proteins. We first identified the possible basal body-targeting sequence in IFT46 by expressing IFT46 truncation constructs in an ift46-1 mutant. The C-terminal sequence between...
Includes: Supplementary data
Journal Articles
In collection:
Cilia and Flagella
J Cell Sci (2016) 129 (3): 621–636.
Published: 1 February 2016
.... 26 8 2015 9 12 2015 © 2016. Published by The Company of Biologists Ltd 2016 We next asked whether the persistence of CP110–Cep97 binding to the basal body is the only cause for the cilia assembly defect in WDR8-depleted RPE-1 cells. To test this hypothesis, we ectopically...
Includes: Supplementary data
Journal Articles
J Cell Sci (2015) 128 (7): 1294–1307.
Published: 1 April 2015
... MAP6 Microtubule Microtubule-stabilizing protein Cilium Centriole Basal body Flagellum Axoneme Cytoskeleton Spermatozoon Epithelial cell Primary cilia are present on the surface of most human cells, and motile cilia are present in tracheal epithelium, ependyma, epididymis, oviduct...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (13): 2803–2810.
Published: 1 July 2014
...Chad G. Pearson ABSTRACT Centrioles and basal bodies (CBBs) are microtubule-rich cylindrical structures that nucleate and organize centrosomes and cilia, respectively. Despite their apparent ninefold rotational symmetry, the nine sets of triplet microtubules in CBBs possess asymmetries...
Journal Articles
J Cell Sci (2014) 127 (11): 2407–2419.
Published: 1 June 2014
...Carmen C. Leitch; Sukanya Lodh; Victoria Prieto-Echagüe; Jose L. Badano; Norann A. Zaghloul ABSTRACT Proteins associated with primary cilia and basal bodies mediate numerous signaling pathways, but little is known about their role in Notch signaling. Here, we report that loss of the Bardet-Biedl...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (15): 3441–3451.
Published: 1 August 2013
...Ian Ross; Christina Clarissa; Thomas H. Giddings, Jr; Mark Winey Summary Basal bodies and centrioles are conserved microtubule-based organelles the improper assembly of which leads to a number of diseases, including ciliopathies and cancer. Tubulin family members are conserved components...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (7): 1659–1671.
Published: 1 April 2013
... at the plasma membrane by basal bodies, which are cylindrical microtubule-based structures with ninefold radial symmetry. In the unicellular ciliate Tetrahymena thermophila , two centrin family members associated with the basal body are important for both basal body organization and stabilization. We have...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (13): 3173–3184.
Published: 1 July 2012
... duplication of a centrin-containing cytoskeletal structure known as the bilobe. We show that TbPLK has a dynamic localization pattern during the cell cycle. The kinase localizes to the basal body, which nucleates the flagellum, and then successively localizes to a series of cytoskeletal structures...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (17): 2964–2975.
Published: 1 September 2011
... as a scaffold for the assembly of the centriole precursor. * Author for correspondence ( hirono@biol.s.u-tokyo.ac.jp ) 17 5 2011 © 2011. 2011 Centriole Basal body Cartwheel SAS-6 bld10 bld12 Mouse cells were washed with PBS and fixed with −20°C methanol for 10 minutes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2622–2630.
Published: 1 August 2011
...Lina Ma; Andrew P. Jarman A significant number of ciliary disease genes have been found to encode proteins that localise to the basal body. By contrast, a large number of basal-body-associated proteins remain to be characterised. Here, we report the identification of a new basal body protein...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (15): 2539–2551.
Published: 1 August 2011
.... Electron microscopy and live imaging showed that cells lacking EB1 or EB3 are defective in MT minus-end anchoring at the centrosome and/or basal body, and possess abnormally short cilia stumps surrounded by vesicles. Further, GST pull-down assays, mass spectrometry and immunoprecipitation indicated...
Includes: Supplementary data