... dynamically remodel in response to physiological forces that challenge epithelial barrier function, such as cell shape changes (e.g. during cell division) or tissue stretching (e.g. during developmental morphogenesis). In this Review, we first introduce a framework to think about TJ remodeling across multiple...

... no competing or financial interests. © 2017. Published by The Company of Biologists Ltd 2017 Summary: This Cell Science at a Glance article presents the current understanding of the molecular components and pathways that regulate mucosal barriers in health and disease. Barrier function...

...Michaela T. Niessen; Sandra Iden; Carien M. Niessen Summary The establishment and maintenance of cell and tissue polarity is crucial for a range of biological processes, such as oriented division, migration, adhesion and barrier function. The molecular pathways that regulate cell and tissue...

... events is not relevant. Among the transmembrane proteins located in TJ strands are occludin, tricellulin, junctional adhesion molecule and the claudin family, the latter has a pivotal role in intestinal barrier function ( Amasheh et al., 2002 ; Furuse et al., 1993 ; Ikenouchi et al., 2005...

...@immunologie.uni-kiel.de ) 5 1 2004 © The Company of Biologists Limited 2004 2004 Barrier function Cathepsin D Cornified envelope Epidermal differentiation Involucrin Loricrin Filaggrin Keratin Sphingomyelinase Transglutaminase The goal of epidermal differentiation is to form...