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Keywords: Autophagy
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Journal Articles
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Membrane Trafficking
J Cell Sci (2022) 135 (8): jcs259421.
Published: 28 April 2022
... homolog, Bph1. We show that Bph1 is an endosomal protein and an effector of the minor Rab5 isoform Ypt52. Strikingly, bph1 Δ mutant cells have lipidated Atg8 on their endosomes, which is sorted via late endosomes into the vacuole lumen under non-autophagy-inducing conditions. In agreement...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs259402.
Published: 9 March 2022
... or financial interests. © 2022. Published by The Company of Biologists Ltd 2022 Summary: This Cell Science at a Glance article and accompanying poster provides an overview of the cellular mechanisms governing lipophagy in yeast and mammals. Autophagy Lipid droplet Lipolysis Lipophagy...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs258733.
Published: 30 December 2021
... to vesicular trafficking events. The sorting nexin (SNX) protein family controls the sorting of a large array of cargoes, and various SNXs impact autophagy. To improve our understanding of their functions in vivo , we screened all Drosophila SNXs using inducible RNA interference in the fat body. Significantly...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (24): jcs259306.
Published: 20 December 2021
...-derived cell lines. DRAIC activates AMP-activated protein kinase (AMPK) by downregulating the NF-κB target gene GLUT1, and thus represses mTOR, leading to downstream effects, such as a decrease in protein translation and increase in autophagy. DRAIC, therefore, has an effect on multiple signal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (22): jcs258699.
Published: 19 November 2021
... organisms, it has been lost in multiple lineages during evolution. In the present study, we compared the localization and function of fly and nematode Stx17s expressed in HeLa cells with those of human Stx17. We found that fly Stx17 predominantly localizes to the cytosol and mediates autophagy...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (19): jcs258824.
Published: 6 October 2021
...Anne F. J. Janssen; Giel Korsten; Wilco Nijenhuis; Eugene A. Katrukha; Lukas C. Kapitein ABSTRACT Degradation of aggregates by selective autophagy is important as damaged proteins may impose a threat to cellular homeostasis. Although the core components of the autophagy machinery are well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs252981.
Published: 3 August 2021
... intracellular pathogens is of utmost significance. Pathogenic intrusion activates autophagy and phagocytic pathways that culminate in the lysosome, a vital organelle responsible for pathogen clearance. The transcription factor TFEB plays a pivotal role in autophagy-lysosomal function. Although TFEB...
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (13): jcs233742.
Published: 6 July 2021
...Sidi Zhang; Yutaro Hama; Noboru Mizushima ABSTRACT Autophagy is a degradative pathway for cytoplasmic constituents, and is conserved across eukaryotes. Autophagy-related ( ATG ) genes have undergone extensive multiplications and losses in different eukaryotic lineages, resulting in functional...
Journal Articles
J Cell Sci (2021) 134 (11): jcs253781.
Published: 7 June 2021
... causes an impaired cytoprotective nitric oxide response otherwise necessary for heat stress tolerance. ATG32 Autophagy Mitophagy Nitric oxide S-adenosyl methionine Spermidine Mitochondria are essential for the generation of energy and essential metabolites but are prone to aging...
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (9): jcs254714.
Published: 11 May 2021
.... and Subramani , S. ( 2015 ). Peroxisomal Pex3 activates selective autophagy of peroxisomes via interaction with the pexophagy receptor Atg30 . J. Biol. Chem. 290 , 8623 - 8631 . 10.1074/jbc.M114.619338 Dupres , V. , Alsteens , D. , Wilk , S. , Hansen , B. , Heinisch , J. J...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (8): jcs255877.
Published: 28 April 2021
... ) Handling Editor: Tamotsu Yoshimori Competing interests The authors declare no competing or financial interests. 22 10 2020 15 3 2021 © 2021. Published by The Company of Biologists Ltd 2021 Summary: The autophagy proteins TMEM41B and VMP1 belong to the DedA...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (8): jcs254904.
Published: 22 April 2021
...+ levels has been shown to be neurotoxic and a causal factor driving the progression of neurodegenerative disorders, as well as affecting neuronal autophagy. Because of its central role in the brain, deficits in nuclear Ca 2+ signaling may underlie a continuous loss of neuroprotection in the aging brain...
Journal Articles
J Cell Sci (2021) 134 (6): jcs249276.
Published: 26 March 2021
... between the ER and mitochondria, thereby impacting processes dependent on mitochondrial Ca 2+ levels, including autophagy and apoptosis. * Author for correspondence ( supattapone@dartmouth.edu ) Handling Editor: Jennifer Lippincott-Schwartz Competing interests The authors declare...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (6): jcs248203.
Published: 22 March 2021
...Toshiharu Fujita; Sayaka Kubo; Tatsuya Shioda; Ayaka Tokumura; Satoshi Minami; Megumi Tsuchiya; Yoshitaka Isaka; Hidesato Ogawa; Maho Hamasaki; Li Yu; Tamotsu Yoshimori; Shuhei Nakamura ABSTRACT TFEB, a basic helix-loop-helix transcription factor, is a master regulator of autophagy, lysosome...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (5): jcs252148.
Published: 8 March 2021
... , with participation of autophagy-related proteins ATG5, LC3-II and LAMP-1, as well as for aggregation of the bacteria with p62 (also known as SQSTM1). This process was impaired in CRAMP −/− macrophages, resulting in retention of intracellular bacteria and fragmentation of macrophages. These results indicate...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (4): jcs253682.
Published: 26 February 2021
...Shintaro Kira; Masafumi Noguchi; Yasuhiro Araki; Yu Oikawa; Tamotsu Yoshimori; Aiko Miyahara; Takeshi Noda ABSTRACT Under starvation conditions, cells degrade their own components via autophagy in order to provide sufficient nutrients to ensure their survival. However, even if starvation persists...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (5): jcs251835.
Published: 25 February 2021
...Azia S. Evans; Nicholas J. Lennemann; Carolyn B. Coyne ABSTRACT Autophagy is a degradative cellular pathway that targets cytoplasmic contents and organelles for turnover by the lysosome. Various autophagy pathways play key roles in the clearance of viral infections, and many families of viruses...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (4): jcs256255.
Published: 22 February 2021
...Paul J. Wrighton; Arkadi Shwartz; Jin-Mi Heo; Eleanor D. Quenzer; Kyle A. LaBella; J. Wade Harper; Wolfram Goessling ABSTRACT Mitophagy, the selective recycling of mitochondria through autophagy, is a crucial metabolic process induced by cellular stress, and defects are linked to aging, sarcopenia...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (3): jcs250670.
Published: 10 February 2021
... component VPS35, we observed accumulation of ATG9A on endolysosomes and early endosomes, respectively. Moreover, starvation-induced autophagosome biogenesis and autophagic flux were inhibited when SNX4 was downregulated. We propose that proper ATG9A recycling by SNX4 sustains autophagy by preventing...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (2): jcs247056.
Published: 22 January 2021
...Timothy Marsh; Bhairavi Tolani; Jayanta Debnath ABSTRACT Autophagy is deregulated in many cancers and represents an attractive target for therapeutic intervention. However, the precise contributions of autophagy to metastatic progression, the principle cause of cancer-related mortality, is only now...