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Keywords: Autophagy
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Journal Articles
J Cell Sci (2024) 137 (4): jcs261655.
Published: 23 February 2024
... pluripotency. In addition to alterations in the gene expression profile, cellular reprogramming requires rearrangement of the proteome, organelles and metabolism, but these changes are comparatively less studied. In this context, autophagy, a cellular catabolic process that participates in the recycling...
Journal Articles
J Cell Sci (2024) 137 (4): jcs261081.
Published: 22 February 2024
...Alexander R. van Vliet; Harold B. J. Jefferies; Peter A. Faull; Jessica Chadwick; Fairouz Ibrahim; Mark J. Skehel; Sharon A. Tooze ABSTRACT ATG9A, a transmembrane protein of the core autophagy pathway, cycles between the Golgi, endosomes and a vesicular compartment. ATG9A was recently shown to act...
Includes: Supplementary data
Journal Articles
J Cell Sci (2024) 137 (3): jcs260481.
Published: 8 February 2024
...Akshaya Nambiar; Ravi Manjithaya ABSTRACT Most of the vesicular transport pathways inside the cell are facilitated by molecular motors that move along cytoskeletal networks. Autophagy is a well-explored catabolic pathway that is initiated by the formation of an isolation membrane known...
Journal Articles
Journal Articles
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Autophagy
J Cell Sci (2023) 136 (16): jcs259725.
Published: 15 August 2023
...Jose L. Nieto-Torres; Sviatlana Zaretski; Tianhui Liu; Peter D. Adams; Malene Hansen ABSTRACT Autophagy is a recycling mechanism involved in cellular homeostasis with key implications for health and disease. The conjugation of the ATG8 family proteins, which includes LC3B (also known as MAP1LC3B...
Journal Articles
J Cell Sci (2023) 136 (12): jcs261028.
Published: 14 June 2023
... of histones. In recent decades, proteomic analyses have revealed that p300 is also involved in the regulation of various cellular processes by acetylating many non-histone proteins. Among the identified substrates, some are key players involved in different autophagy steps, which together establish p300...
Journal Articles
J Cell Sci (2023) 136 (11): jcs260638.
Published: 6 June 2023
... preserving neuronal energy homeostasis. Here, we review the contribution of mitophagy, a selective form of autophagy that targets dysfunctional or superfluous mitochondria for degradation, in maintaining nervous system homeostasis. In addition, we discuss recent evidence implicating defective or dysregulated...
Journal Articles
J Cell Sci (2023) 136 (10): jcs260888.
Published: 31 May 2023
...Bernd Bauer; Sascha Martens; Luca Ferrari ABSTRACT Cells keep their proteome functional by the action of the proteostasis network, composed of the chaperones, the ubiquitin-proteasome system and autophagy. The decline of this network results in the accumulation of protein aggregates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2023) 136 (8): jcs260741.
Published: 24 April 2023
... – and related degradation pathways are discussed, including potential links to disease. Autophagy Crinophagy Secretion National Research, Development and Innovation Office http://dx.doi.org/10.13039/501100018818 2022-2.1.1-NL-2022-00008 PD135447 ÚNKP-22-5-ELTE-826 KKP129797...
Journal Articles
Journal Articles
In collection:
Autophagy
J Cell Sci (2023) 136 (6): jcs246348.
Published: 24 March 2023
... for Vps1 accumulation and activity on peroxisomes. Dynamin-related protein Peroxisome Autophagy Drp1 University of Sheffield http://dx.doi.org/10.13039/501100000858 Saudi Arabia Cultural Bureau in London http://dx.doi.org/10.13039/100012363 University of Bisha...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2023) 136 (3): jcs260546.
Published: 9 February 2023
...Pablo Sánchez-Martín; Franziska Kriegenburg; Ludovico Alves; Julius Adam; Jana Elsaesser; Riccardo Babic; Hector Mancilla; Mariya Licheva; Georg Tascher; Christian Münch; Stefan Eimer; Claudine Kraft ABSTRACT Autophagy is a catabolic process during which cytosolic material is enwrapped in a newly...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2022) 135 (17): jcs259778.
Published: 7 September 2022
... Person interview with the first author of the paper. References Adachi , A. , Koizumi , M. and Ohsumi , Y . ( 2017 ). Autophagy induction under carbon starvation conditions is negatively regulated by carbon catabolite repression . J. Biol. Chem. 292 , 19905 - 19918 . 10.1074...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2022) 135 (14): jcs259857.
Published: 20 July 2022
... in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration . Cell. Signal. 26 , 2694 - 2701 . 10.1016/j.cellsig.2014.08.019 Hyde , K. D. , Dong , Y. , Phookamsak , R. , Jeewon , R. , Bhat , D. J. , Jones , E. B. G. , Liu , N.-G...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2022) 135 (11): jcs255802.
Published: 10 June 2022
...Eugenia Almacellas; Caroline Mauvezin ABSTRACT Lysosomes exert pleiotropic functions to maintain cellular homeostasis and degrade autophagy cargo. Despite the great advances that have boosted our understanding of autophagy and lysosomes in both physiology and pathology, their function in mitosis...
Journal Articles
In collection:
Autophagy
J Cell Sci (2022) 135 (11): jcs258997.
Published: 6 June 2022
... autophagosomal membranes, are among the most-studied autophagy components. Despite the research focus on the core ATG8 system, there are conflicting reports regarding its essential roles in autophagy. Here, we reconcile prior observations of the core ATG8 system into a unifying model of their function that aims...
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (8): jcs259421.
Published: 28 April 2022
... homolog, Bph1. We show that Bph1 is an endosomal protein and an effector of the minor Rab5 isoform Ypt52. Strikingly, bph1 Δ mutant cells have lipidated Atg8 on their endosomes, which is sorted via late endosomes into the vacuole lumen under non-autophagy-inducing conditions. In agreement...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs259402.
Published: 9 March 2022
... ). The Troyer syndrome protein spartin mediates selective autophagy of lipid droplets . bioRxiv 2021.2008.2018.456894 . 10.1101/2021.08.18.456894 Cloherty , A. P. M. , Olmstead , A. D. , Ribeiro , C. M. S. and Jean , F. ( 2020 ). Hijacking of lipid droplets by Hepatitis C, Dengue...
Includes: Supplementary data