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Keywords: Autophagy
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2023) 136 (1): jcs260563.
Published: 12 January 2023
... buds and micronuclei containing autophagy proteins in a basal way and in response to DNA double strand breaks, suggesting homeostatic nuclear maintenance by nucleophagy. Mammalian nucleophagy Autophagy DNA damage Nucleolus Micronuclei Consejo Nacional de Ciencia y Tecnología http...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (17): jcs259778.
Published: 7 September 2022
... in Saccharomyces cerevisiae . * Author for correspondence ( jroelofs@kumc.edu ) References Adachi , A. , Koizumi , M. and Ohsumi , Y . ( 2017 ). Autophagy induction under carbon starvation conditions is negatively regulated by carbon catabolite repression . J. Biol. Chem. 292...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (15): jcs259738.
Published: 2 August 2022
..., suppression of autophagy by 3-methyladenine (3-MA) treatment compromised the effect of metformin on DNA damage. In vivo studies also showed that 3-MA might diminish the therapeutic effect of metformin on IVDD. Taken together, our results reveal that metformin may suppress senescence via inactivating the cGAS...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (14): jcs259857.
Published: 20 July 2022
... in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration . Cell. Signal. 26 , 2694 - 2701 . 10.1016/j.cellsig.2014.08.019 Hyde , K. D. , Dong , Y. , Phookamsak , R. , Jeewon , R. , Bhat , D. J. , Jones , E. B. G. , Liu , N.-G...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2022) 135 (11): jcs255802.
Published: 10 June 2022
...Eugenia Almacellas; Caroline Mauvezin ABSTRACT Lysosomes exert pleiotropic functions to maintain cellular homeostasis and degrade autophagy cargo. Despite the great advances that have boosted our understanding of autophagy and lysosomes in both physiology and pathology, their function in mitosis...
Journal Articles
In collection:
Autophagy
J Cell Sci (2022) 135 (11): jcs258997.
Published: 6 June 2022
... autophagosomal membranes, are among the most-studied autophagy components. Despite the research focus on the core ATG8 system, there are conflicting reports regarding its essential roles in autophagy. Here, we reconcile prior observations of the core ATG8 system into a unifying model of their function that aims...
Journal Articles
In collection:
Membrane Trafficking
J Cell Sci (2022) 135 (8): jcs259421.
Published: 28 April 2022
... homolog, Bph1. We show that Bph1 is an endosomal protein and an effector of the minor Rab5 isoform Ypt52. Strikingly, bph1 Δ mutant cells have lipidated Atg8 on their endosomes, which is sorted via late endosomes into the vacuole lumen under non-autophagy-inducing conditions. In agreement...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs259402.
Published: 9 March 2022
... in yeast and mammals. Autophagy Lipid droplet Lipolysis Lipophagy Metabolism National Institutes of Health http://dx.doi.org/10.13039/100000002 R00AA026877 R01DK044650 R01AA020735 Lipid droplets (LDs) play important roles in numerous cell types across virtually all species...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (5): jcs258733.
Published: 30 December 2021
... to vesicular trafficking events. The sorting nexin (SNX) protein family controls the sorting of a large array of cargoes, and various SNXs impact autophagy. To improve our understanding of their functions in vivo , we screened all Drosophila SNXs using inducible RNA interference in the fat body. Significantly...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (24): jcs259306.
Published: 20 December 2021
...-derived cell lines. DRAIC activates AMP-activated protein kinase (AMPK) by downregulating the NF-κB target gene GLUT1, and thus represses mTOR, leading to downstream effects, such as a decrease in protein translation and increase in autophagy. DRAIC, therefore, has an effect on multiple signal...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (22): jcs258699.
Published: 19 November 2021
... organisms, it has been lost in multiple lineages during evolution. In the present study, we compared the localization and function of fly and nematode Stx17s expressed in HeLa cells with those of human Stx17. We found that fly Stx17 predominantly localizes to the cytosol and mediates autophagy...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (19): jcs258824.
Published: 6 October 2021
...Anne F. J. Janssen; Giel Korsten; Wilco Nijenhuis; Eugene A. Katrukha; Lukas C. Kapitein ABSTRACT Degradation of aggregates by selective autophagy is important as damaged proteins may impose a threat to cellular homeostasis. Although the core components of the autophagy machinery are well...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (15): jcs252981.
Published: 3 August 2021
... intracellular pathogens is of utmost significance. Pathogenic intrusion activates autophagy and phagocytic pathways that culminate in the lysosome, a vital organelle responsible for pathogen clearance. The transcription factor TFEB plays a pivotal role in autophagy-lysosomal function. Although TFEB...
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (13): jcs233742.
Published: 6 July 2021
...Sidi Zhang; Yutaro Hama; Noboru Mizushima ABSTRACT Autophagy is a degradative pathway for cytoplasmic constituents, and is conserved across eukaryotes. Autophagy-related ( ATG ) genes have undergone extensive multiplications and losses in different eukaryotic lineages, resulting in functional...
Journal Articles
J Cell Sci (2021) 134 (11): jcs253781.
Published: 7 June 2021
... in cellular SAM and spermidine levels, which in turn causes an impaired cytoprotective nitric oxide response otherwise necessary for heat stress tolerance. ATG32 Autophagy Mitophagy Nitric oxide S-adenosyl methionine Spermidine Mitochondria are essential for the generation of energy...
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (9): jcs254714.
Published: 11 May 2021
... Wsc1 also regulates pexophagy through a downstream MAPK pathway that mediates phospho-regulation of the pexophagy receptor protein Atg30. Peroxisome Autophagy Mitogen-activated protein kinase Organelle homeostasis Pexophagy Autophagy refers to the degradation pathway of cellular...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2021) 134 (8): jcs255877.
Published: 28 April 2021
...: The autophagy proteins TMEM41B and VMP1 belong to the DedA superfamily, whose members are predicted to have ion-coupled transporter-like structures containing two facing reentrant loops. DedA VMP1 TMEM41B Reentrant loop Autophagy § Author for correspondence ( nmizu@m.u-tokyo.ac.jp...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (8): jcs254904.
Published: 22 April 2021
...+ levels has been shown to be neurotoxic and a causal factor driving the progression of neurodegenerative disorders, as well as affecting neuronal autophagy. Because of its central role in the brain, deficits in nuclear Ca 2+ signaling may underlie a continuous loss of neuroprotection in the aging brain...
Journal Articles
J Cell Sci (2021) 134 (6): jcs249276.
Published: 26 March 2021
... between the ER and mitochondria, thereby impacting processes dependent on mitochondrial Ca 2+ levels, including autophagy and apoptosis. Fig. 6. Effect of SERCA inhibition on apoptosis in WT and SEC24A KO cells. (A) WT cells were pre-treated with 400 µM Q-VD-OPh or DMSO for 1 h before treatment...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (6): jcs248203.
Published: 22 March 2021
...Toshiharu Fujita; Sayaka Kubo; Tatsuya Shioda; Ayaka Tokumura; Satoshi Minami; Megumi Tsuchiya; Yoshitaka Isaka; Hidesato Ogawa; Maho Hamasaki; Li Yu; Tamotsu Yoshimori; Shuhei Nakamura ABSTRACT TFEB, a basic helix-loop-helix transcription factor, is a master regulator of autophagy, lysosome...
Includes: Supplementary data