... candidate genes, we identified the RNA-binding gene ELAV like protein 1 ( 256529 ), which encodes the protein Hu antigen R (HuR). Depletion of HuR led to less cell death induced by dsRNA. HuR is mainly involved in apoptosis, and all of its RNA recognition motifs are essential for its pro-apoptotic function...

...Sweksha Lohani; Yosuke Funato; Yuki Akieda; Kiyohito Mizutani; Yoshimi Takai; Tohru Ishitani; Hiroaki Miki ABSTRACT Maintaining proper epithelial cell density is essential for the survival of multicellular organisms. Although regulation of cell density through apoptosis is well known, its...

...-prolyl cis / trans isomerase (PPIase), it catalyzes the cis - trans isomerization of proline amidic peptide bonds, through which it regulates a variety of biological processes, such as intracellular signaling, transcription and apoptosis. In this study, we found that intracellular CypA enhanced Twist1...

...Yuxia Lin; Changbai Huang; Huixin Gao; Xiaobo Li; Quanshi Lin; Shili Zhou; Zhiting Huo; Yanxia Huang; Chao Liu; Ping Zhang ABSTRACT Apoptosis is an important cellular response to viral infection. In this study, we identified activating molecule in Beclin1-regulated autophagy protein 1 (AMBRA1...

...Nadine Pollak; Aline Lindner; Dirke Imig; Karsten Kuritz; Jacques S. Fritze; Lorena Decker; Isabel Heinrich; Jannis Stadager; Stephan Eisler; Daniela Stöhr; Frank Allgöwer; Peter Scheurich; Markus Rehm ABSTRACT Extrinsic apoptosis relies on TNF-family receptor activation by immune cells or receptor...

...) that link SAC activation to the initiation of cell death remain unknown. We show here that activated Cdk1 forms a complex with the pro-apoptotic proteins Bax and Bak (also known as BAK1) during SAC-induced apoptosis . Bax- and Bak-mediated delivery of activated Cdk1 to the mitochondrion is essential...

... by a topoisomerase inhibitor. Thapsigargin-treated SEC24A -knockout cells showed a ∼2.5-fold increase in autophagic flux and ∼10-fold reduction in apoptosis compared to wild-type cells. Taken together, our findings indicate that SEC24A plays a previously unrecognized role in regulating association and Ca 2+ flux...

... of the cell, suggesting that both proteins form a functional unit, the high level of expression of which plays a significant role in cell survival. CyPA has also been related to the mechanism of apoptosis by favouring the nuclear translocation of apoptosis-inducing factor (AIF) ( Zhu et al., 2007...

... signalling and facilitate inflammation, differentiation and cell survival. TNF-Rs use distinct adaptor molecules to activate signalling cascades. Fas-associated protein with death domain (FADD) family adaptors often mediate apoptosis, and TNF-R-associated factor (TRAF) family adaptors mediate cell...

... the treatment of the anti-tumor therapeutic reagent arsenite. IKKα triggers its own degradation, as a feedback loop, by activating p53-dependent autophagy, and therefore contributes substantially to hepatoma cell apoptosis induced by arsenite. Interestingly, IKKα is unable to interact with p53 directly...

... that is required for the formation of glycogen-containing structures. Glycogen ER stress Glycogenin Glycogen synthase UPR Apoptosis The endoplasmic reticulum (ER) is an intracellular network of interconnected membranes involved in a variety of cellular processes including synthesis, folding...

...Elaheh Sadat Hosseini; Maryam Nikkhah; Amir Ali Hamidieh; Howard O. Fearnhead; Jean-Paul Concordet; Saman Hosseinkhani ABSTRACT Detection of the apoptosis signature becomes central in understanding cell death modes. We present here a whole-cell biosensor that detects Apaf-1 association...

...Priyanka S. Rana; Manabu Kurokawa; Michael A. Model ABSTRACT Potassium loss and persistent shrinkage have both been implicated in apoptosis but their relationship and respective roles remain controversial. We approached this problem by clamping intracellular sodium and potassium in HeLa or MDCK...

..., whether peroxisomes also regulate mitochondrial fission–fusion dynamics or mitochondrion-dependent apoptosis remained unclear. We now show that genetic ablation of the peroxins Pex3 or Pex5, which are essential for peroxisome biogenesis, results in mitochondrial fragmentation in mouse embryonic...

..., and this increase exacerbated Dox-induced cardiomyocyte apoptosis and mitochondrial dysfunction. Overexpressing Dkk1 aggravated Dox-induced cardiotoxicity in H 9 C 2 cells. Similar results were detected when adding active Dkk1 protein extracellularly. Conversely, adding specific antibody blocking extracellular Dkk1...

...Shalini Roy; Shriya Saha; Purnima Gupta; Anindita Ukil; Pijush K. Das ABSTRACT Previously, we documented the role of the programmed death-1 (PD-1, also known as PDCD1) pathway in macrophage apoptosis and the downregulation of this signaling during infection by the intra-macrophage parasite...

... of survivin in all eukaryotes from yeast (where the survivin homologue is known as Bir1) ( Rajagopalan and Balasubramanian, 2002 ) to human. Accordingly, loss or depletion of survivin leads to prometaphase defects, cytokinesis failure, mitotic catastrophe and increased apoptosis in all model systems ( Lens et...

.... N. ( 2008 ). Selective apoptosis of breast cancer cells by siRNA targeting of BORIS . Biochem. Biophys. Res. Commun.   370 , 109 - 112 . 10.1016/j.bbrc.2008.03.040 Heath , H. , Ribeiro De Almeida , C. , Sleutels , F. , Dingjan , G. , Van De Nobelen , S. , Jonkers...

... and unfolded protein response (UPR) pathways. Consequently, specific molecular chaperones have been validated as targets for anti-cancer therapies. For example, inhibition of Hsp70 family proteins (hereafter Hsp70) in rhabdomyosarcoma triggers UPR induction and apoptosis. To define how these cancer cells...

...Victoria H. Ng; Brian I. Hang; Leah M. Sawyer; Leif R. Neitzel; Emily E. Crispi; Kristie L. Rose; Tessa M. Popay; Alison Zhong; Laura A. Lee; William P. Tansey; Stacey Huppert; Ethan Lee ABSTRACT X-linked inhibitor of apoptosis (XIAP) plays an important role in preventing apoptotic cell death. XIAP...