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Keywords: Apoptosis
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Journal Articles
In collection:
Mitochondria
J Cell Sci (2023) 136 (22): jcs260790.
Published: 23 November 2023
...Louise E. King; Lisa Hohorst; Ana J. García-Sáez ABSTRACT The proteins of the BCL-2 family are known as key regulators of apoptosis, with interactions between family members determining permeabilisation of the mitochondrial outer membrane (MOM) and subsequent cell death. However, the exact...
Includes: Supplementary data
Journal Articles
Journal Articles
J Cell Sci (2023) 136 (7): jcs260915.
Published: 27 March 2023
... the inhibitory effect of MDM2 on GADD45α, resulting in GADD45α accumulation and cell apoptosis. In the current study, we show that there is a strong induction of ISG20L1 (also known as AEN) expression in several cancer cell lines under exposure of arsenite and other chemotherapeutic agents. Surprisingly...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (23): jcs260110.
Published: 7 December 2022
..., such as the prothoracic gland and the fat body, is necessary for their proper functioning. Reduction of NOC1 in epithelial cells from the imaginal discs results in clones that die by apoptosis, an event that is partially rescued in a Minute /+ background, suggesting that reduction of NOC1 induces the cells to become less...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (23): jcs259634.
Published: 30 November 2022
..., thereby preventing ER stress-induced apoptosis ( Ngoh et al., 2012 ). PERK overexpression also induced mitochondrial fragmentation ( Muñoz et al., 2013 ), highlighting the importance of the UPR at the interface of multiple cellular signaling pathways as well as mitochondrial membrane dynamics. PERK has...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (6): jcs258855.
Published: 14 March 2022
... candidate genes, we identified the RNA-binding gene ELAV like protein 1 ( 256529 ), which encodes the protein Hu antigen R (HuR). Depletion of HuR led to less cell death induced by dsRNA. HuR is mainly involved in apoptosis, and all of its RNA recognition motifs are essential for its pro-apoptotic function...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs258550.
Published: 26 January 2022
...Sweksha Lohani; Yosuke Funato; Yuki Akieda; Kiyohito Mizutani; Yoshimi Takai; Tohru Ishitani; Hiroaki Miki ABSTRACT Maintaining proper epithelial cell density is essential for the survival of multicellular organisms. Although regulation of cell density through apoptosis is well known, its...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (2): jcs259018.
Published: 17 January 2022
...-prolyl cis / trans isomerase (PPIase), it catalyzes the cis - trans isomerization of proline amidic peptide bonds, through which it regulates a variety of biological processes, such as intracellular signaling, transcription and apoptosis. In this study, we found that intracellular CypA enhanced Twist1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (1): jcs258910.
Published: 7 January 2022
...Yuxia Lin; Changbai Huang; Huixin Gao; Xiaobo Li; Quanshi Lin; Shili Zhou; Zhiting Huo; Yanxia Huang; Chao Liu; Ping Zhang ABSTRACT Apoptosis is an important cellular response to viral infection. In this study, we identified activating molecule in Beclin1-regulated autophagy protein 1 (AMBRA1...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
J Cell Sci (2021) 134 (6): jcs249276.
Published: 26 March 2021
... by a topoisomerase inhibitor. Thapsigargin-treated SEC24A -knockout cells showed a ∼2.5-fold increase in autophagic flux and ∼10-fold reduction in apoptosis compared to wild-type cells. Taken together, our findings indicate that SEC24A plays a previously unrecognized role in regulating association and Ca 2+ flux...
Includes: Supplementary data
Journal Articles
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (2): jcs255422.
Published: 25 January 2021
... signalling and facilitate inflammation, differentiation and cell survival. TNF-Rs use distinct adaptor molecules to activate signalling cascades. Fas-associated protein with death domain (FADD) family adaptors often mediate apoptosis, and TNF-R-associated factor (TRAF) family adaptors mediate cell...
Includes: Supplementary data
Journal Articles
In collection:
Autophagy
J Cell Sci (2020) 133 (22): jcs246868.
Published: 16 November 2020
... the treatment of the anti-tumor therapeutic reagent arsenite. IKKα triggers its own degradation, as a feedback loop, by activating p53-dependent autophagy, and therefore contributes substantially to hepatoma cell apoptosis induced by arsenite. Interestingly, IKKα is unable to interact with p53 directly...
Journal Articles
J Cell Sci (2020) 133 (20): jcs244855.
Published: 26 October 2020
... that is required for the formation of glycogen-containing structures. Glycogen ER stress Glycogenin Glycogen synthase UPR Apoptosis The endoplasmic reticulum (ER) is an intracellular network of interconnected membranes involved in a variety of cellular processes including synthesis, folding...
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Journal Articles
Journal Articles
J Cell Sci (2020) 133 (9): jcs243931.
Published: 11 May 2020
...Priyanka S. Rana; Manabu Kurokawa; Michael A. Model ABSTRACT Potassium loss and persistent shrinkage have both been implicated in apoptosis but their relationship and respective roles remain controversial. We approached this problem by clamping intracellular sodium and potassium in HeLa or MDCK...
Journal Articles
In collection:
Mitochondria
J Cell Sci (2019) 132 (11): jcs224766.
Published: 31 May 2019
..., whether peroxisomes also regulate mitochondrial fission–fusion dynamics or mitochondrion-dependent apoptosis remained unclear. We now show that genetic ablation of the peroxins Pex3 or Pex5, which are essential for peroxisome biogenesis, results in mitochondrial fragmentation in mouse embryonic...
Includes: Supplementary data
Journal Articles
J Cell Sci (2019) 132 (10): jcs228478.
Published: 16 May 2019
..., and this increase exacerbated Dox-induced cardiomyocyte apoptosis and mitochondrial dysfunction. Overexpressing Dkk1 aggravated Dox-induced cardiotoxicity in H 9 C 2 cells. Similar results were detected when adding active Dkk1 protein extracellularly. Conversely, adding specific antibody blocking extracellular Dkk1...
Includes: Supplementary data