... of mouse 3T3-L1 cells into adipocytes, cells undergo one or two rounds of cell division called mitotic clonal expansion (MCE). MCE is an essential step for adipogenesis; however, little is known about the regulation of DNA replication during this period. Here, we performed genome-wide mapping...

... differentiation and differentiation-associated mitochondrial biogenesis. We found that DRP1 is essential for the induction of the early-phase beige adipogenic transcriptional program. Intriguingly, inhibition of DRP1 is dispensable following the induction of beige adipogenesis and adipogenesis-associated...

...Yan Zhang; Mei Yu; Minjia Dai; Chang Chen; Qi Tang; Wei Jing; Hang Wang; Weidong Tian ABSTRACT Adipose tissue is an active endocrine organ that can secrete a wide number of factors to regulate adipogenesis via paracrine signals. In addition to soluble proteins in adipose tissue, microRNAs (miRNAs...

...Hongyao Yu; Ke He; Lina Wang; Jing Hu; Junjie Gu; Chenlin Zhou; Rui Lu; Ying Jin ABSTRACT A better understanding of molecular regulation in adipogenesis might help the development of efficient strategies to cope with obesity-related diseases. Here, we report that CCAAT/enhancer-binding protein (C...

... in brown adipocyte development is unknown. Here, we show that Bmal1 (also known as ARNTL), the essential clock transcription activator, inhibits brown adipogenesis to adversely affect brown fat formation and thermogenic capacity. Global ablation of Bmal1 in mice increases brown fat mass and cold tolerance...

...Jong Hyun Kim; Jung Ho Lee; Min Chul Park; Ina Yoon; Kibom Kim; Minji Lee; Hueng-Sik Choi; Jung Min Han; Sunghoon Kim ABSTRACT Adipogenesis is known to be controlled by the concerted actions of transcription factors and co-regulators. However, little is known about the mechanism of regulation...

...Jennifer Baltes; Jakob Vejby Larsen; Karthikeyan Radhakrishnan; Constanze Geumann; Manuel Kratzke; Claus Munck Petersen; Peter Schu ABSTRACT Here, we describe altered sorting of sortilin in adipocytes deficient for the σ1B-containing AP-1 complex, leading to the inhibition of adipogenesis. The AP-1...

... PPARγ and C/EBPα, and adoption of a lipid-laden adipocyte morphology. By contrast, myogenic cells did not undergo adipogenesis and showed differential regulation of PPARγ and C/EBPα in response to these adipogenic treatments. Our results show that human skeletal muscle fibroblasts are at least bipotent...

...Judith Toneatto; Sergio Guber; Nancy L. Charó; Sebastián Susperreguy; Jessica Schwartz; Mario D. Galigniana; Graciela Piwien-Pilipuk Summary Glucocorticoids play an important role in adipogenesis through the glucocorticoid receptor (GR) that forms a heterocomplex with Hsp90•Hsp70 and one high...

... molecule Akt (also known as PKB). We propose that LAR functions as a negative regulator of adipogenesis. Furthermore, our data support the possibility that LAR controls the balance between osteoblast and adipocyte differentiation. Overall, our findings contribute to the clarification of the mechanisms...

...-catenin and emerin influenced each other's levels of expression and the onset of adipogenesis, suggesting that changes in the expression of nuclear lamina proteins were intimately linked to the stability of β-catenin. By contrast, dermal fibroblasts, which are emerin null, demonstrated increased nuclear...

...C. Christodoulides; M. Laudes; W. P. Cawthorn; S. Schinner; M. Soos; S. O'Rahilly; J. K. Sethi; A. Vidal-Puig Secretion of Wnts by adipose cells has an important role in the control of murine adipogenesis. We present the first evidence that a Wnt antagonist, Dickkopf 1 (Dkk1), is secreted by human...

.... The deduced amino acid sequence was shown to have a basic leucine zipper motif and a NOC domain. Expression of fad24 was rapidly induced after stimulation with inducers. Furthermore, overexpression of fad24 in NIH-3T3 cells promoted adipogenesis in the presence of a ligand for peroxisome proliferator...

..., a transcriptionally active β-catenin mutant reversed the delay in osteoblast differentiation and the exuberant adipogenesis. Thus, in vivo disruption of cadherin function hinders osteoblast differentiation and favors, indirectly, bone marrow progenitor cell commitment to the alternative adipogenic lineage via...

.... ( 2001 ). Stromelysin-1 regulates adipogenesis during mammary gland involution. J. Cell Biol. 152 , 693 -703. Asakura, M., Kitakaze, M., Takashima, S., Liao, Y., Ishikura, F., Yoshinaka, T., Ohmoto, H., Node, K., Yoshino, K., Ishiguro, H. et al. ( 2002 ). Cardiac hypertrophy is inhibited...

..., and induces lipid formation under certain culture conditions. * Author for correspondence (e-mail: strosberg@icgm.cochin.inserm.fr ) 15 08 1999 18 10 1999 © 1999 by Company of Biologists 1999 Adrenergic receptor β AR Adipocyte Adipogenesis PPARγ CHO The β 3...

... adipogenesis when treated at confluence with the appropriate hormonal inducers. Addition of TCDD before or concurrent with hormonal induction suppressed PPARγ mRNA and adipogenesis, as measured by lipid accumulation, glycerol phosphate dehydrogenase activity and stearoyl CoA desaturase type 1 mRNA expression...

...Miriam J. Smyth; Rodney L. Sparks; Walker Wharton * Author for correspondence © 1993 by Company of Biologists 1993 differentiation proliferation adipogenesis growth arrest adipocyte-specific gene expression flow cytometry The relationship between growth arrest...

..., demonstrate an inverse relationship between the differentiation of adipocytic and osteogenic cells in this culture system and are consistent with the possibility that the regulation of adipogenesis and osteogenesis can occur at the level of a common precursor in vivo . * Author for correspondence...