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Keywords: Actomyosin
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Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2021) 134 (18): jcs259221.
Published: 24 September 2021
... by releasing Ca 2+ to activate the actin-based motor myosin II at the cell rear. However, how the actomyosin cytoskeleton physically associates to lysosomes is unknown. We have previously identified myosin II as a direct interactor of Rab7b, a small GTPase that mediates the transport from late endosomes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (8): jcs254409.
Published: 22 April 2021
... Summary: This Review highlights recent advances and questions remaining in the field of cytokinesis, and how gene editing tools will facilitate significant advances in the field. CRISPR RhoA Actomyosin Cytokinesis Gene editing Cytokinesis occurs at the end of mitosis to physically...
Journal Articles
J Cell Sci (2020) 133 (10): jcs235846.
Published: 26 May 2020
...Aparna Sherlekar; Gayatri Mundhe; Prachi Richa; Bipasha Dey; Swati Sharma; Richa Rikhy ABSTRACT Branched actin networks driven by Arp2/3 interact with actomyosin filaments in processes such as cell migration. Similar interactions occur in the syncytial Drosophila blastoderm embryo where expansion...
Includes: Supplementary data
Journal Articles
In collection:
Adhesion
J Cell Sci (2019) 132 (22): jcs229286.
Published: 21 November 2019
... scales: from molecular dynamics, to strand dynamics, to cell- and tissue-scale dynamics. We then relate knowledge gained from global perturbations of TJs to emerging information about local TJ remodeling events, where transient localized Rho activation and actomyosin-mediated contraction promote TJ...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2019) 132 (19): jcs231357.
Published: 9 October 2019
...Deepika Singh; Devang Odedra; Priyanka Dutta; Christian Pohl ABSTRACT During animal development, cells need to sense and adapt to mechanical forces from their environment. Ultimately, these forces are transduced through the actomyosin cortex. How the cortex simultaneously responds to and creates...
Includes: Supplementary data
Journal Articles
J Cell Sci (2017) 130 (24): 4200–4212.
Published: 15 December 2017
... evolution of cortical PAR proteins during Caenorhabditis elegans embryogenesis. It is also capable of accurate tracking of varying levels of transgene expression and discontinuous signals of the actomyosin cytoskeleton during multiple rounds of cell division. ImaEdge provides a unique resource...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2016) 129 (24): 4496–4508.
Published: 15 December 2016
... and the actomyosin cytoskeleton, during Drosophila embryonic dorsal closure, by studying a newly developed allelic series. We find that α-Catenin regulates pulsatile apical contraction in the amnioserosa, the main force-generating tissue driving closure of the embryonic epidermis. α-Catenin controls actomyosin...
Includes: Supplementary data
Journal Articles
In collection:
Mechanobiology
J Cell Sci (2016) 129 (19): 3574–3582.
Published: 1 October 2016
... role in MAPK signaling, has been implicated in mechanical processes in cells, such as migration. Here, we identify the actin-binding protein calponin-3 as a new MEKK1 substrate in the signaling that regulates actomyosin-based cellular contractility. MEKK1 colocalizes with calponin-3 at the actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (22): 4927–4939.
Published: 15 November 2014
... © 2014. Published by The Company of Biologists Ltd 2014 Rab proteins Rab7b Endosomes Actomyosin A complex intracellular compartmentalization is a distinctive feature of eukaryotic cells. To ensure proper communication through the endomembrane system, the transport between all...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (16): 3440–3450.
Published: 15 August 2014
...), a mechanosensor at focal adhesions, correlates with actin retrograde flow and depends upon actomyosin contraction and phosphorylation of the Cas substrate domain (CasSD). This indicates that CasSD phosphorylation underpins the physical link between Cas and the actin cytoskeleton. Fluorescence recovery after...
Includes: Supplementary data
Journal Articles
J Cell Sci (2014) 127 (8): 1660–1671.
Published: 15 April 2014
... and dynamics. MTs progressed less, with a lower elongation rate, towards cadherin adhesions than towards focal adhesions. Increased actin treadmilling and the presence of an actomyosin contractile belt, suggested that actin relays inhibitory signals from cadherin adhesions to MTs. The reduced rate of MT...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (24): 5585–5597.
Published: 15 December 2013
... is a well-characterized modulator of actomyosin contractility, but the function of other GTPases, such as Rac, in regulating contractility is currently not well understood. Here, we show that activation of Rac by the guanine nucleotide exchange factor Asef2 (also known as SPATA13) impairs migration on type...
Includes: Supplementary data
Journal Articles
J Cell Sci (2013) 126 (5): 1260–1267.
Published: 1 March 2013
... signaling. Epidermal growth factor-induced phosphorylation of myosin II regulatory light chains was abolished by STIM1 knockdown and SOCE inhibition. Dual immunostaining of activated myosin II (pSer19-MLC) and actin revealed that actomyosin formation depended on STIM1-mediated Ca 2+ entry. Most importantly...
Includes: Supplementary data
Journal Articles
J Cell Sci (2012) 125 (23): 5860–5872.
Published: 1 December 2012
... bind G-actin induce aberrant actomyosin structures dependent on their nuclear accumulation and on PP1 binding. In CHL-1 melanoma cells, Phactr1 exhibits actin-regulated subcellular localisation and is required for stress fibre assembly, motility and invasiveness. These data support a role for Phactr1...
Includes: Supplementary data
Journal Articles
J Cell Sci (2011) 124 (12): 2086–2095.
Published: 15 June 2011
...Christine M. Field; Martin Wühr; Graham A. Anderson; Hao Yuan Kueh; Devin Strickland; Timothy J. Mitchison The mechanical properties of cells change as they proceed through the cell cycle, primarily owing to regulation of actin and myosin II. Most models for cell mechanics focus on actomyosin...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2011) 124 (4): 635–646.
Published: 15 February 2011
...Hye Young Kim; Lance A. Davidson Actomyosin networks linked to the micro-environment through the plasma membrane are thought to be key players in regulating cell behaviors within multicellular tissues, such as converging and extending mesoderm. Here, we observe the dynamics of actin contractions...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2009) 122 (12): 2137–2148.
Published: 15 June 2009
... actomyosin network. The mechanism of DLHP formation is poorly understood, although several essential genes have been identified, among them Zic2 , which encodes a zinc-finger transcription factor. We found that DLHP formation in the zebrafish midbrain also requires actomyosin and Zic function. Given...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2006) 119 (17): 3583–3592.
Published: 1 September 2006
... interference of class IA phosphoinositide 3-kinase abrogates both directional extension and maintenance of the long leading process, whereas PTEN modulates the size of the protrusion. Actomyosin contractility is important for coordinated spreading of the tip of the leading process in situ. Finally, ErbB4...
Includes: Multimedia, Supplementary data
Journal Articles
J Cell Sci (2003) 116 (8): 1481–1491.
Published: 15 April 2003
...-matrix adhesions. J. Cell Sci. 114 , 3583 -3590. * Author for correspondence (e-mail: matthew.petroll@utsouthwestern.edu ) 7 1 2003 © The Company of Biologists Limited 2003 2003 Focal adhesions Focal complexes Cell motility Collagen lattice Actomyosin Cell mechanics...
Includes: Multimedia, Supplementary data