...Xuekai Xiong; Weini Li; Jin Nam; Meng Qu; Steve A. Kay; Ke Ma ABSTRACT The circadian clock is entrained to daily environmental cues. Integrin-linked signaling via actin cytoskeleton dynamics transduces physical niche cues from the extracellular matrix to myocardin-related transcription factor (MRTF...

..., and muscle regulatory proteins . J. Biol. Chem. 270 , 11437 - 11444 . 10.1074/jbc.270.19.11437 Kovar , D. R. , Sirotkin , V. and Lord , M. ( 2011 ). Three's company: the fission yeast actin cytoskeleton . Trends Cell Biol. 21 , 177 - 187 . 10.1016/j.tcb.2010.11.001...

... on the mechanobiology of pluripotent stem cells, highlighting distinctive cellular properties associated with pluripotency and remaining open questions. Actin cytoskeleton Cell mechanics Mechanobiology Pluripotent stem cells References Acharya , B. R. , Wu , S. K. , Lieu , Z. Z. , Parton...

...-scale membrane dynamics Endothelium Transendothelial cell macroaperture Bacterial toxin Actin cytoskeleton References Aird , W. C. ( 2007 ). Vascular bed-specific thrombosis . J. Thromb. Haemost. 5 , 283 - 291 . 10.1111/j.1538-7836.2007.02515.x Antonny , B...

... depletion in tumour cells caused redistribution of the actin cytoskeleton and increased activity of the Rho GTPase CDC42, known for its role in actin remodelling and cell migration. In a xenograft model of breast cancer, tumour cell CD99 expression inhibited metastatic progression, and patient samples...

... was increased 3.96±1.45 fold at 1 min and 3.94±1.57 at 5 min (mean±s.d.) after cell activation ( Fig. 7 C). Fig. 7. β-actin, ABPs and actin cytoskeleton regulatory proteins are interacting partners of RACK1 in MCs. RBL-2H3 MCs were antigen stimulated or not. RACK1 was immunoprecipitated (IP RACK1...

... cytokines with chemokine-like functions that coordinate a wide spectrum of biological activities, such as migration. Here, we biotin-tagged intracellular MIF/D-DT in vivo to identify important cytosolic interactors and found a plethora of actin cytoskeleton-associated proteins. Although the receptor complex...

... the hyphae shape and growth direction ( Crampin et al., 2005 ). Directional bud tip expansion requires effective vesicular transport between the Spitzenkörper and the hyphae tip, which depends on actin cables ( Taheri-Talesh et al., 2012 ). Disruption of the actin cytoskeleton can lead to the disappearance...

.... , Wong , C. C. , Bailey , A. O. , Yates , J. R. , Mogilner , A. , Zebroski , H. and Kashina , A. ( 2006 ). Arginylation of beta-actin regulates actin cytoskeleton and cell motility . Science   313 , 192 - 196 . 10.1126/science.1129344 Kijima , S. T. , Hirose , K...

... remodeling, giant cells in immune response, and how do they compare with known fusogens? Second, how do the actin cytoskeleton and fusogens coordinate in various cell–cell fusion events? Third, are there additional types of lipids that modulate cell–cell fusion? Finally, once a nano-sized fusion pore has...

... dynamics in the two cells types ( Fig. 2 D), or might emanate from a lack of negative regulators of TCR signalling, such as SHIP-1 and PTEN, in Jurkat T-cells ( Abraham and Weiss, 2004 ), thereby compensating for the architectural deficits in the actin cytoskeleton. Mechanisms by which Jurkat T-cells...

...Salma Jalal; Shidong Shi; Vidhyalakshmi Acharya; Ruby Yun-Ju Huang; Virgile Viasnoff; Alexander D. Bershadsky; Yee Han Tee ABSTRACT Actin cytoskeleton self-organization in two cell types, fibroblasts and epitheliocytes, was studied in cells confined to isotropic adhesive islands. In fibroblasts...

... declare no competing or financial interests. Summary: The transmission of mechanical signals through cellular assemblies regulates collective cell behavior. Cell–cell junctions Mechanobiology Actin cytoskeleton Collective cell migration Active matter The ability of metazoan cells...

... that myosin-2 motors drive actin network contraction via a polarity-sorting mechanism that relies on dwelling of myosins at the plus end of actin filaments. Actin cytoskeleton Actin-myosin contraction Active gel Cell cortex Myosin end-dwelling Polarity sorting Cells have the remarkable...

.... PAWS1 FAM83G CD2AP Cell migration Actin cytoskeleton Cell migration is involved in embryonic development, wound healing, the immune response and cancer metastasis ( Easley et al., 2008 ; Fife et al., 2014 ). Although many of the molecules and biophysical processes involved in cell migration...

... of interstitial migration in vivo . While neutrophils are classic amoeboid cells, macrophages have a distinct morphology and use a more mesenchymal mode of migration in zebrafish larvae. Migration Neutrophil Macrophage Microtubule Actin cytoskeleton Zebrafish Macrophages and neutrophils...

...Klemens Rottner; Jan Faix; Sven Bogdan; Stefan Linder; Eugen Kerkhoff ABSTRACT The actin cytoskeleton and associated motor proteins provide the driving forces for establishing the astonishing morphological diversity and dynamics of mammalian cells. Aside from functions in protruding and contracting...

.... and De Camilli , P. ( 2005 ). The Abl/Arg substrate ArgBP2/nArgBP2 coordinates the function of multiple regulatory mechanisms converging on the actin cytoskeleton . Proc. Natl. Acad. Sci. USA   102 , 1731 - 1736 . 10.1073/pnas.0409376102 Chen , H. , Choudhury , D. M. and Craig...

... nonmuscle myosin IIB is essential for epicardial development. This function of nonmuscle myosin IIB is critical in the regulation of myocardial proliferation and coronary vessel formation. Nonmuscle myosin IIB Epicardial integrity Epicardial epithelial–mesenchymal transition Actin cytoskeleton...

...Riko Hatakeyama; Keiko Kono; Satoshi Yoshida ABSTRACT The plasma membrane (PM) is frequently challenged by mechanical stresses. In budding yeast, TORC2-Ypk1/Ypk2 kinase cascade plays a crucial role in PM stress responses by reorganizing the actin cytoskeleton via Rho1 GTPase. However, the molecular...