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Keywords: Actin
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Journal Articles
J Cell Sci jcs.260366.
Published: 2 February 2023
...Franziska Lehne; Sven Bogdan Exocytosis is a fundamental cellular process by which cells secret cargos from their apical membrane into the extracellular lumen. Cargo release proceeds in sequential steps that depend on a coordinated assembly and organization of an actin cytoskeletal network. Here...
Journal Articles
In collection:
Motors , Polarity
J Cell Sci (2023) 136 (5): jcs260300.
Published: 17 October 2022
..., for intracellular transport. Here we describe how molecular motors and cytoskeletal tracks can generate streaming. Actin Cytoplasmic streaming Dynein Kinesin Microtubules Myosin National Institute of General Medical Sciences http://dx.doi.org/10.13039/100000057 R35 GM131752...
Includes: Supplementary data
Journal Articles
Series: REVIEW COMMONS TRANSFER
J Cell Sci (2022) 135 (19): jcs260511.
Published: 3 October 2022
...). Assembled virions accumulate in the lumen of the VCC, from where they can be released into the extracellular medium via mechanisms that remain poorly described. Here, we show that the actin cytoskeleton contributes to this process by performing experiments combining pharmacological and mechanical...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (18): jcs260288.
Published: 23 September 2022
... ABSTRACT Tropomyosins are structurally conserved α-helical coiled-coil proteins that bind along the length of filamentous actin (F-actin) in fungi and animals. Tropomyosins play essential roles in the stability of actin filaments and in regulating myosin II contractility. Despite the crucial role...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (16): jcs259993.
Published: 26 August 2022
... tension control is thus essential for understanding cell morphogenesis. Increasing evidence shows that alongside myosin activity, actin network organisation and composition are key to cortex tension regulation. However, owing to a poor understanding of how cortex composition changes when tension changes...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (14): jcs259623.
Published: 18 July 2022
... unknown. Here, we investigate the role of actin, Rho GTPases and microtubules, which are major players in CIE processes, in this mechanism. We show that the actin cytoskeleton is dynamically associated with endoA3- and CD166-positive endocytic carriers, and that its perturbation strongly inhibits...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (13): jcs259692.
Published: 4 July 2022
... in the presence of dynamic F-actin exhibit a striking bilobed nuclear morphology with distinct membrane compositions in the two lobes and accumulation of F-actin at the inner nuclear envelope. The addition of Lamin A (encoded by lmna ), which is absent from Xenopus eggs, results in rounder nuclei, suggesting...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (10): jcs259042.
Published: 27 May 2022
...Hendrik Schürmann; Fatemeh Abbasi; Antonella Russo; Arne D. Hofemeier; Matthias Brandt; Johannes Roth; Thomas Vogl; Timo Betz ABSTRACT Podosomes are mechanosensitive protrusive actin structures that are prominent in myeloid cells, and they have been linked to vascular extravasation. Recent studies...
Includes: Supplementary data
Journal Articles
J Cell Sci (2022) 135 (10): jcs259030.
Published: 16 May 2022
... on the cell-type-specific mechanisms regulating ciliogenesis at the apical surface in polarized epithelial cells, which are particularly relevant for many ciliopathies. Furthermore, recent findings have demonstrated the importance of actin cytoskeleton dynamics in positively and negatively regulating multiple...
Journal Articles
In collection:
Cytoskeleton , Imaging
J Cell Sci (2022) 135 (7): jcs259234.
Published: 8 April 2022
...Joseph Atherton; Melissa Stouffer; Fiona Francis; Carolyn A. Moores ABSTRACT Neurons extend axons to form the complex circuitry of the mature brain. This depends on the coordinated response and continuous remodelling of the microtubule and F-actin networks in the axonal growth cone. Growth cone...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2022) 135 (1): jcs258850.
Published: 10 January 2022
... ABSTRACT Septins, a family of GTP-binding proteins that assemble into higher order structures, interface with the membrane, actin filaments and microtubules, and are thus important regulators of cytoarchitecture. Septin 9 (SEPT9), which is frequently overexpressed in tumors and mutated in hereditary...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (24): jcs259237.
Published: 20 December 2021
...Anne Bourdais; Benoit Dehapiot; Guillaume Halet ABSTRACT How multiple actin networks coexist in a common cytoplasm while competing for a shared pool of monomers is still an ongoing question. This is exemplified by meiotic maturation in the mouse oocyte, which relies on the dynamic remodeling...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (24): jcs259085.
Published: 15 December 2021
...Hanchong Zhang; Zihang Cheng; Wenbo Li; Jie Hu; Linyue Zhao; Dan Chen; Jinghu Gao; Juan Chen; Yanling Yan; Long Lin; Anbing Shi ABSTRACT The disruption of endosomal actin architecture negatively affects endocytic recycling. However, the underlying homeostatic mechanisms that regulate actin...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (23): jcs258891.
Published: 9 December 2021
... finally tested whether a phosphomimetic WAVE SD mutant of the VCA domain exhibits a higher protein stability or actin polymerization activity in vivo . Here, we used the Drosophila wing imaginal disc as an in vivo model to measure the effect of the WAVE overexpression. We used the en -Gal4 driver...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (23): jcs258802.
Published: 6 December 2021
...Marie-Thérèse Prospéri; Julien Pernier; Hugo Lachuer; Evelyne Coudrier ABSTRACT EphB2–ephrinB signalling, which plays a major role in cell segregation during embryonic development and tissue homeostasis, induces an important reorganization of the cortical actin network. We have previously reported...
Includes: Supplementary data
Journal Articles
In collection:
Cytoskeleton
J Cell Sci (2021) 134 (21): jcs258973.
Published: 5 November 2021
... function for the distribution of F-actin plus and minus ends. In syncytial Drosophila embryos, Rho1 signaling is high between actin caps, i.e. the cortical intercap region. Capping protein binds to free plus ends of F-actin to prevent elongation of the filament. Capping protein has served as a marker...
Includes: Supplementary data
Journal Articles
In collection:
Polarity
J Cell Sci (2021) 134 (20): jcs258523.
Published: 18 October 2021
... by The Company of Biologists Ltd 2021 Summary: The LLxY motif in the C-terminal region of ATP11C-b, a phosphatidylserine flippase, is crucial for its interaction with ezrin, as well as its polarized localization in motile cells. Actin Biological membrane Ezrin Flippase Polarization...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (14): jcs254011.
Published: 19 July 2021
...Caitlin C. Devitt; Chanjae Lee; Rachael M. Cox; Ophelia Papoulas; José Alvarado; Shashank Shekhar; Edward M. Marcotte; John B. Wallingford ABSTRACT The dynamic control of the actin cytoskeleton is a key aspect of essentially all animal cell movements. Experiments in single migrating cells...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (12): jcs244384.
Published: 21 June 2021
...Nicholas V. G. Iannantuono; Gregory Emery ABSTRACT Cytokinesis occurs at the end of mitosis/meiosis wherein the cytoplasms of daughter cells are separated. Before abscission, an intercellular bridge containing the remaining furrowing machinery, mitotic spindle and actin cytoskeleton connects...
Includes: Supplementary data
Journal Articles
J Cell Sci (2021) 134 (9): jcs249060.
Published: 7 May 2021
...Abigail Allen; David Gau; Partha Roy ABSTRACT Dynamic remodeling of the actin cytoskeleton is an essential feature for virtually all actin-dependent cellular processes, including cell migration, cell cycle progression, chromatin remodeling and gene expression, and even the DNA damage response...