...Michael Bachmann; Markus Schäfer; Vasyl V. Mykuliak; Marta Ripamonti; Lia Heiser; Kai Weißenbruch; Sarah Krübel; Clemens M. Franz; Vesa P. Hytönen; Bernhard Wehrle-Haller; Martin Bastmeyer ABSTRACT αVβ3 integrin can bind to multiple extracellular matrix proteins, including vitronectin (Vn...

... and BIK. The effect on gelatin degradation was abrogated by inhibition of the MMP-14 activity and appeared to be dependent on cell surface αVβ3 integrin localization, but neither the catalytic activity of ADAM12 nor the cytoplasmic tail of ADAM12 were required. The significance of ADAM12-induced...

... of time. Fig. 1. Cell-free interaction of Tat with αvβ3 integrin. (A) Aliquots of purified human αvβ3 were incubated on plastic coated with BSA, FN, GST or GST-Tat. At the end of incubation, plastic-bound proteins were extracted and analysed by western blotting with anti-β3 antibodies. (B) Purified αvβ3...

...-rich tyrosine kinase (PYK2) in osteoclasts. Engagement of αvβ3 integrin triggered ERK1/2 phosphorylation, but the underlying molecular mechanism was surprisingly independent of the well known Shc/Ras/Raf-1 cascade, and of phosphorylated MAP/ERK kinase (MEK)1/2, so far the only recognized direct...