Cover: Cell stained to visualize the microtubule cytoskeleton and imaged using a structured illumination microscope. The same image was duplicated and misaligned to illustrate the type of image correction that can be performed using Fast4DReg. Credit: Guillaume Jacquemet. See article by J. W. Pylvänäinen et al. (jcs260728).
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CELL SCIENTISTS TO WATCH
The X chromosome still has a lot to reveal – revisiting Hermann Henking's work on firebugs
Ubiquitin and its relatives as wizards of the endolysosomal system
Summary: A Review of ubiquitylation and its biochemical relatives as regulators of the endolysosomal system and its hijacking by intracellular bacteria in order for them to prosper inside cells.
Field model for multistate lateral diffusion of various transmembrane proteins observed in living Dictyostelium cells
Summary: The complex diffusion behaviors of various transmembrane proteins in Dictyostelium cells can be explained quantitatively by free diffusion on three membrane regions of different viscosities.
Single-chromosome dynamics reveals locus-dependent dynamics and chromosome territory orientation
Summary: Chromosome compaction depends on the cell cycle and the chromosome arm. In vivo, chromatin dynamics, which are modulated by transcription and interactions between chromatin and nuclear landmarks, are genomic-locus specific.
Lamin A/C phosphorylation at serine 22 is a conserved heat shock response to regulate nuclear adaptation during stress
Highlighted Article: Phosphorylation of nuclear lamin A/C at Ser22 is an evolutionarily conserved mechanism that regulates lamin dynamics to serve nuclear adaptation and cell survival in heat-shocked cells.
Re-organization of nucleolar architecture in myogenic differentiation
Highlighted Article: Nucleolar architecture is altered during myogenic differentiation, indicating that the phase separation properties and function of the nucleolus might change during myogenesis.
Toxoplasma gondii scavenges mammalian host organelles through the usurpation of host ESCRT-III and Vps4A
Summary: The parasitophorous vacuole of Toxoplasma gondii sequesters host organelles by utilizing TgGRA14 and TgGRA64, which interact with host ESCRT proteins for vacuolar membrane remodeling and fission.
Cleavage of the Jaw1 C-terminal region enhances its augmentative effect on the Ca2+ release via IP3 receptors
Highlighted Article: The C-terminal region of Jaw1, a tail-anchored protein, is cleaved by the signal peptidase complex and this cleavage event enhances the augmentative effect of Jaw1 on the Ca2+ release activity of inositol 1,4,5-trisphosphate receptors.
TOOLS AND RESOURCES
Fast4DReg – fast registration of 4D microscopy datasets
Summary: Fast4DReg is an open-source Fiji plugin that can quickly correct axial and lateral drift in multidimensional microscopy datasets.
Correction: Fluid shear stress regulates the survival of circulating tumor cells via nuclear expansion
Reasons to submit to Journal of Cell Science
There are many benefits to publishing through Journal of Cell Science, follow this link to read more about our reasons to submit or visit our submission page now.
Call for papers: Cell and Tissue Polarity
We are welcoming submissions for our next special issue, which will focus on ‘Cell and tissue polarity’ and will be guest edited by David Bryant. Submission deadline: 15 July.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Journal of Cell Science a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
Propose a new Workshop for 2025
Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
FocalPlane Image Competition 2023
FocalPlane’s 2023 image competition is underway, in celebration of the community site’s third birthday. Click here for submission details and information on how to showcase your favourite image.