Issues

Summary: Polycystin channels reside on cilia of cells in many important tissues, and polycystin mutations can lead to polycystic kidney disease. Here, we review working models describing ciliary polycystin function.

Summary: A review of the composition and assembly of centriolar appendages, as well as their roles in development and disease.

Highlighted Article: Dominant-negative mutations in DRP1 identified in patients with EMPF1 result in mitochondrial and peroxisomal hyperfusion, severe alterations in mitochondrial membrane potential and metabolic reprograming.

Summary: Using intravital imaging and an avian embryo xenograft model, we show that canonical Wnt and ATF2 signalling pathways have complementary activity patterns during human cancer cell invasion and metastasis.

Summary: The SNARE protein YKT6 plays a conserved role in autophagosome formation and fusion with lysosomes, which is controlled by the ULK1 kinase.

Summary: The Pil1 homolog Lsp1 is sufficient for eisosome assembly under various types of membrane stress in yeast. Eisosome assembly is connected to respiration, the TCA cycle, DNA repair, ribosome biogenesis and cell cycle.

Summary: COPII vesicle formation and trafficking of plasma membrane proteins depend on the phosphorylated state of S134 in Erv14

Summary: Ski family transcriptional corepressor 1 (SKOR1), which has been mainly associated with neuronal development, is a direct substrate of the oncogenic tyrosine kinase FER and a driver of triple-negative breast cancer progression.

Highlighted Article: Propagating waves of intracellular cGMP were visualized in chemotactic Dictyostelium cells with a fluorescent probe. Increased intracellular cGMP levels induced a transient shuttle of myosin II between the cytosol and cell cortex.

Highlighted Article: Mitotic fidelity in the fission yeast S. pombe, which undergoes closed mitosis, requires diacylglycerol consumption fueling a spike in glycerophospholipid biosynthesis to enable nuclear membrane expansion.

Summary: The primary cilium is a microtubule-based organelle that acts as a signaling nexus. The ciliopathy-linked protein CCDC66 is required for assembling signaling-competent cilia with proper structure and size.