Issues
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Cover image
Cover Image
Cover: Confocal image depicting a SKOR1-mutant triple-negative breast cancer cell. The image has been stylised using the Oil Paint filter in Adobe Photoshop. Focal adhesions and the heart-shaped nucleus are highlighted in red, and the homogenous cytoplasmic distribution of overexpressed mutant SKOR1 is shown in green. SKOR1-mutant cells exhibit a non-invasive phenotype, including extensive cell spreading and abundant focal adhesion sites, which is in clear contrast to the well-known aggressive phenotype of the parental triple-negative breast cancer cells. See article by L. M. Sluimer et al. (jcs260243).
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RESEARCH HIGHLIGHTS
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Ciliary mechanosensation – roles of polycystins and mastigonemes
Summary: Polycystin channels reside on cilia of cells in many important tissues, and polycystin mutations can lead to polycystic kidney disease. Here, we review working models describing ciliary polycystin function.
Structure and function of distal and subdistal appendages of the mother centriole
Summary: A review of the composition and assembly of centriolar appendages, as well as their roles in development and disease.
RESEARCH ARTICLES
DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs
Highlighted Article: Dominant-negative mutations in DRP1 identified in patients with EMPF1 result in mitochondrial and peroxisomal hyperfusion, severe alterations in mitochondrial membrane potential and metabolic reprograming.
Intravital imaging of Wnt/β-catenin and ATF2-dependent signalling pathways during tumour cell invasion and metastasis
Summary: Using intravital imaging and an avian embryo xenograft model, we show that canonical Wnt and ATF2 signalling pathways have complementary activity patterns during human cancer cell invasion and metastasis.
ULK1-mediated phosphorylation regulates the conserved role of YKT6 in autophagy
Summary: The SNARE protein YKT6 plays a conserved role in autophagosome formation and fusion with lysosomes, which is controlled by the ULK1 kinase.
Lsp1 partially substitutes for Pil1 function in eisosome assembly under stress conditions
Summary: The Pil1 homolog Lsp1 is sufficient for eisosome assembly under various types of membrane stress in yeast. Eisosome assembly is connected to respiration, the TCA cycle, DNA repair, ribosome biogenesis and cell cycle.
The C-terminus of the cargo receptor Erv14 affects COPII vesicle formation and cargo delivery
Summary: COPII vesicle formation and trafficking of plasma membrane proteins depend on the phosphorylated state of S134 in Erv14
SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells
Summary: Ski family transcriptional corepressor 1 (SKOR1), which has been mainly associated with neuronal development, is a direct substrate of the oncogenic tyrosine kinase FER and a driver of triple-negative breast cancer progression.
Dynamics of intracellular cGMP during chemotaxis in Dictyostelium cells
Highlighted Article: Propagating waves of intracellular cGMP were visualized in chemotactic Dictyostelium cells with a fluorescent probe. Increased intracellular cGMP levels induced a transient shuttle of myosin II between the cytosol and cell cortex.
Diacylglycerol at the inner nuclear membrane fuels nuclear envelope expansion in closed mitosis
Highlighted Article: Mitotic fidelity in the fission yeast S. pombe, which undergoes closed mitosis, requires diacylglycerol consumption fueling a spike in glycerophospholipid biosynthesis to enable nuclear membrane expansion.
CCDC66 regulates primary cilium length and signaling via interactions with transition zone and axonemal proteins
Summary: The primary cilium is a microtubule-based organelle that acts as a signaling nexus. The ciliopathy-linked protein CCDC66 is required for assembling signaling-competent cilia with proper structure and size.
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JCS Journal Meeting 2023: Imaging Cell Dynamics

Our 2023 Journal Meeting on ‘Imaging Cell Dynamics’ will be held from 14-17 May 2023 in Lisbon, Portugal. Due to popular demand, we can currently only accept applications for online attendance. Apply now to attend this meeting virtually. Registration deadline: 31 March.
Call for papers: Cell and Tissue Polarity
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We are welcoming submissions for our next special issue, which will focus on ‘Cell and tissue polarity’ and will be guest edited by David Bryant. Submission deadline: 15 July.
Editorial: Publishing where it matters
Editor-in-Chief Michael Way outlines Journal of Cell Science’s plans for the upcoming year and introduces Seema Grewal as our new Executive Editor.
preLights 5th Birthday webinar

preLights, our preprint highlighting service, is celebrating its 5th birthday this year. To mark the occasion, join us online on 14 March 2023 at 16:00 GMT for a discussion, led by four preLights alumni, on how to identify and navigate the challenges and opportunities while shaping your career as an early-career researcher.
Cell Scientists to Watch

As a community-focused journal, Journal of Cell Science is keen to support the next generation of cell biologists. Check out Cell Scientists to Watch, our interview series featuring talented researchers who have recently set up their own labs.