CELL SCIENTISTS TO WATCH
Summary: We review the evolution of self-organizing systems, focusing on cell polarization in Saccharomyces cerevisiae and its relatives, and offer a shift in perspective on evolution at the molecular scale.
Summary: A discussion of the catalytic and non-catalytic functions of the three N-terminal methyltransferases to enable better understanding of their biological roles.
Highlighted Article: Substrate stiffness modulates mechanotransduction of Notch signaling in endothelial cells. This might have implications for pathologies involving extracellular matrix stiffening, such as tumor growth.
A member of the claudin superfamily influences formation of the front domain in pheromone-responding yeast cells
Summary: The claudin superfamily member, Dcv1, facilitates the proper localization of plasma membrane lipids and proteins that are required for front–rear polarity, efficient chemotropism and cell fusion in yeast.
Summary: CCDC86 was identified as a novel component of the perichromosomal layer and was found to be important for chromosome segregation. It represents a strong prognostic marker for neuroblastoma patients.
Functional crosstalk between the TIM22 complex and YME1 machinery maintains mitochondrial proteostasis and integrity
Summary: A unique genetic coordination between the TIM22 complex and YME1 machinery balances mitochondrial protein biogenesis and quality control, thereby maintaining cellular health.
Summary: SART3 interacts with post-splicing complexes in a DHX15-dependent manner, suggesting that SART3 associates with the post-splicing complex, interacts there with U6 snRNA and initiates its recycling.
Cardiomyocyte differentiation from human induced pluripotent stem cells is delayed following knockout of Bcl-2
Summary: Bcl-2 regulates the temporal trajectory of human induced pluripotent stem cell differentiation towards cardiomyocytes in a c-Myc dependent manner.
Reorganization of the DNA replication landscape during adipogenesis is closely linked with adipogenic gene expression
Summary: Regulation of the temporal order of DNA replication during differentiation of 3T3-L1 cells into adipocytes was uncovered and found to be linked with adipogenesis potential.
Summary: Two members of the PDI family, ERp57 and ERdj5, assist secretory protein folding by correcting non-native disulfide bonds. Their contrasting dependency on a reducing pathway reflects their different roles as isomerase and reductase.
The mitotic role of adenomatous polyposis coli requires its bilateral interaction with tubulin and microtubules
Summary: The C-terminal domain of adenomatous polyposis coli (APC) regulates microtubule dynamics and organises ring-like tubulin oligomers around the microtubule wall, and plays a role in mitotic spindle function.
Scribble and E-cadherin cooperate to control symmetric daughter cell positioning by multiple mechanisms
Summary: E-cadherin and Scribble dynamically relocate during division of single cells to orient the mitotic spindle and control placement of the daughter cells.
Endosomal vesicle fusion machinery is involved with the contractile vacuole in Dictyostelium discoideum
Summary: Transcriptomics and fluorescence microscopy of the amoeba Dictyostelium show the involvement of Rabs and SNAREs in regulation of the contractile vacuole, and phylogenetics addresses its evolutionary origins.
The fission yeast kinetochore complex Mhf1–Mhf2 regulates the spindle assembly checkpoint and faithful chromosome segregation
Summary: Mhf2, a component of the inner layer of the proteinaceous kinetochore supercomplex, regulates the spindle assembly checkpoint and faithful chromosome segregation.