Cover: Fluorescence image showing an intact zebrafish embryo at ∼18 h post fertilization. The embryo was immunolabelled using an anti-TPC1 antibody (green) and then stained with fluorescent phalloidin to label F-actin (red). See article by K. L. Rice et al. (jcs259564).
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CELL SCIENTISTS TO WATCH
The roles of inter-tissue adhesion in development and morphological evolution
Summary: The study of how neighboring tissues physically interact with each other, inter-tissue adhesion, is an emerging field at the interface of cell biology, biophysics and developmental biology.
Tubulin isotypes – functional insights from model organisms
Summary: The microtubule cytoskeleton underlies diverse biological processes. Microtubules themselves are composed of multiple tubulin isotypes. We review how model organisms are revealing how these isotypes mediate distinct cellular functions.
Regulation of microtubule detyrosination by Ca2+ and conventional calpains
Summary: Ca2+ and the conventional calpains 1 and 2 regulate microtubule detyrosination. They could indirectly influence vasohibin activity or possibly control another still unknown tubulin carboxypeptidase.
Dissociation of β2m from MHC class I triggers formation of noncovalent transient heavy chain dimers
Summary: Major histocompatibility complex class I heavy chains form noncovalent dimers at the cell surface that are shown to be dynamic and short-lived.
Restoration of DNA integrity and the cell cycle by electric stimulation in planarian tissues damaged by ionizing radiation
Highlighted Article: Exogenous stimulation with electric currents enables DNA damage repair and stem cell reconstitution in planarian tissues exposed to a lethal dose of ionizing radiation.
Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components
Highlighted Article: The GID ubiquitin ligase complex localizes to primary cilia, influences sonic hedgehog signaling and causes phenotypes reminescent of ciliopathies.
Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex
Highlighted Article: Mitochondrial antiviral-signalling protein (MAVS) is a favoured client of the cytosolic BAG6 complex. We discuss how this dynamic interaction may modulate MAVS biogenesis at signalling membranes.
FMRP protects the lung from xenobiotic stress by facilitating the integrated stress response
Summary: The fragile X mental retardation protein protects the epithelial lining of the respiratory tract from xenobiotic stresses by facilitating the induction of the integrated stress response pathway.
De novo formation and maintenance of mammalian peroxisomes in cultured PEX16-knockout cells generated by CRISPR/Cas9
Summary: In contrast to PEX16-deficient fibroblasts from Zellweger syndrome patients, PEX16-knockout HeLa, HEK293 and CHO-K1 cell lines established using the CRISPR/Cas9 system can partially maintain peroxisomes.
Localized TPC1-mediated Ca2+ release from endolysosomes contributes to myoseptal junction development in zebrafish
Summary: Highly localized TPC1-mediated Ca2+ release from endolysosomes contributes to the capture and attachment of superficial slow skeletal muscle cells at myoseptal junctions in zebrafish.
A PKC that controls polyphosphate levels, pinocytosis and exocytosis, regulates stationary phase onset in Dictyostelium
Highlighted Article:Dictyostelium PkcA controls stationary phase entry by negatively regulating polyphosphate concentration and F-actin polymerization under high shear stress, in turn governing pinocytosis and exocytosis.
Annexin A2 and Ahnak control cortical NuMA–dynein localization and mitotic spindle orientation
Summary: The Anx2–Ahnak complex is a novel mitotic cortical element transmitting adhesion cues to regulate cortical NuMA–dynein distribution and mitotic spindle orientation in human cells.
Publisher's Note: Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components
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