Issues
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Cover image
Cover Image
Cover: Fluorescence image showing an intact zebrafish embryo at ∼18 h post fertilization. The embryo was immunolabelled using an anti-TPC1 antibody (green) and then stained with fluorescent phalloidin to label F-actin (red). See article by K. L. Rice et al. (jcs259564).
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RESEARCH HIGHLIGHTS
CELL SCIENTISTS TO WATCH
ESSAYS
REVIEWS
The roles of inter-tissue adhesion in development and morphological evolution
Summary: The study of how neighboring tissues physically interact with each other, inter-tissue adhesion, is an emerging field at the interface of cell biology, biophysics and developmental biology.
Tubulin isotypes – functional insights from model organisms
Summary: The microtubule cytoskeleton underlies diverse biological processes. Microtubules themselves are composed of multiple tubulin isotypes. We review how model organisms are revealing how these isotypes mediate distinct cellular functions.
SHORT REPORT
Regulation of microtubule detyrosination by Ca2+ and conventional calpains
Summary: Ca2+ and the conventional calpains 1 and 2 regulate microtubule detyrosination. They could indirectly influence vasohibin activity or possibly control another still unknown tubulin carboxypeptidase.
RESEARCH ARTICLES
Dissociation of β2m from MHC class I triggers formation of noncovalent transient heavy chain dimers
Summary: Major histocompatibility complex class I heavy chains form noncovalent dimers at the cell surface that are shown to be dynamic and short-lived.
Restoration of DNA integrity and the cell cycle by electric stimulation in planarian tissues damaged by ionizing radiation
Highlighted Article: Exogenous stimulation with electric currents enables DNA damage repair and stem cell reconstitution in planarian tissues exposed to a lethal dose of ionizing radiation.
Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components
Highlighted Article: The GID ubiquitin ligase complex localizes to primary cilia, influences sonic hedgehog signaling and causes phenotypes reminescent of ciliopathies.
Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex
Highlighted Article: Mitochondrial antiviral-signalling protein (MAVS) is a favoured client of the cytosolic BAG6 complex. We discuss how this dynamic interaction may modulate MAVS biogenesis at signalling membranes.
FMRP protects the lung from xenobiotic stress by facilitating the integrated stress response
Summary: The fragile X mental retardation protein protects the epithelial lining of the respiratory tract from xenobiotic stresses by facilitating the induction of the integrated stress response pathway.
De novo formation and maintenance of mammalian peroxisomes in cultured PEX16-knockout cells generated by CRISPR/Cas9
Summary: In contrast to PEX16-deficient fibroblasts from Zellweger syndrome patients, PEX16-knockout HeLa, HEK293 and CHO-K1 cell lines established using the CRISPR/Cas9 system can partially maintain peroxisomes.
Localized TPC1-mediated Ca2+ release from endolysosomes contributes to myoseptal junction development in zebrafish
Summary: Highly localized TPC1-mediated Ca2+ release from endolysosomes contributes to the capture and attachment of superficial slow skeletal muscle cells at myoseptal junctions in zebrafish.
A PKC that controls polyphosphate levels, pinocytosis and exocytosis, regulates stationary phase onset in Dictyostelium
Highlighted Article:Dictyostelium PkcA controls stationary phase entry by negatively regulating polyphosphate concentration and F-actin polymerization under high shear stress, in turn governing pinocytosis and exocytosis.
Annexin A2 and Ahnak control cortical NuMA–dynein localization and mitotic spindle orientation
Summary: The Anx2–Ahnak complex is a novel mitotic cortical element transmitting adhesion cues to regulate cortical NuMA–dynein distribution and mitotic spindle orientation in human cells.
FIRST PERSON
PUBLISHER'S NOTE
Publisher's Note: Cilia-localized GID/CTLH ubiquitin ligase complex regulates protein homeostasis of sonic hedgehog signaling components
2021 JCS Prize winner announced
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We are pleased to announce that the winner of the 2021 JCS Prize is Lee Dolat for his paper entitled ‘An endometrial organoid model of interactions between Chlamydia and epithelial and immune cells’.
Propose a new Workshop
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Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Cell scientist to watch: Christian Münch
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Journal of Cell Science interviewed Christian Münch, who established his independent research group in 2016 at Goethe University Frankfurt. His lab studies cellular stress responses to mitochondrial protein misfolding, infection and disease, as well as developing proteomics methods.
Essay series: Equity, diversity and inclusion in cell biology
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The JCS Essay Series is an initiative to help showcase and provide a platform for voices in the field of cell biology. The first topic we covered was 'Equity, diversity and inclusion in cell biology', and the winning and runner up essays are now available to read.
FocalPlane Network launched
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We are excited to announce the launch of the FocalPlane Network, an international directory of microscopists. The idea behind the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.