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Special Issue: Cell Biology of Lipids


Summary: Coherent Raman scattering microscopy offers label-free imaging of lipid droplets with chemical specificity. Here, we discuss the recent advancement in the field.


Summary: Dynamic S-acylation of Ca2+ release-activated channel Orai1 is required for its recruitment to the plasma membrane subdomains and subsequent activation.


Summary: Different palmitoylation patterns on a lipid kinase adaptor protein control partitioning of the kinase between two spatiotemporally and functionally distinct complexes within the plasma membrane.

Summary: A product of cholesterol ester oxidation that is found in plasma of cardiovascular disease patients induces lysosome stress, culminating with the formation of vascular smooth muscle foam cells.

Summary: Myoblasts exhibit an aminophospholipid flippase activity that relies on CDC50A-dependent P4-ATPases. Loss of CDC50A compromises actin remodeling, RAC1 membrane targeting and cell fusion.

Summary: TMEM55B mediates the transport of lysosomes. We show that TMEM55B undergoes S-palmitoylation at multiple cysteine residues to mediate transport of TMEM55B from the Golgi to lysosomes.

Summary: Membrane contact sites between organelles are critical regulators of cellular function. Here we identify the highly conserved Hob proteins as novel lipid-binding proteins at ER–PM contact sites.

Summary: The resistance–nodulation–division protein Dispatched 1 expels plasma membrane cholesterol to indirectly increase Sonic hedgehog morphogen release from the cell surface.

Summary: Lipoprotein lipase is localized to large caveolar microdomains in 3T3-L1 adipocytes. In these cells, insulin regulates LPL secretion by driving trafficking of these domains via an ARF1-dependent mechanism.

Summary: Exposure to mild heat shock leads to large quantifiable changes in the cellular ultrastructure of yeast, showing the involvement of multivesicular bodies in the heat-shock response and the apparition of novel structures.

Summary: A yeast mating-based microscopic readout is used to monitor the relocalization of lipid droplet proteins. LD proteins of the two mating partners quickly re-equilibrate their localization resulting in a uniform LD population.

Summary: The acyltransferase DHHC21 is a novel component of the TCR signaling pathway that critically regulates activation and differentiation of CD4+ T cells by mediating rapid TCR-induced S-acylation of signaling proteins.

Summary: The junction between the ER membrane and lipid droplets constitutes a barrier for the transfer of ER-resident membrane-spanning proteins to the surface of lipid droplets.

Summary: Cilia of olfactory sensory neurons have a unique lipid composition. Localization of phospholipids is controlled by the INPP5E phosphatase and is involved in modulation of the odor response.

Summary: Yeast cells lacking phosphatidylserine generate protein-depleted plasma membrane domains, and vacuoles contact this domain. This is the first report of micron-scale plasma membrane domains in living cells.

Summary: The synaptotagmin-like mitochondrial-lipid-binding domain of PDZD8 transports phospholipids and ceramides at ER-late endosome/lysosome (LE/lys) contacts to promote LE/lys positioning and neurite outgrowth.

Summary: Septins are critical for cell shape. Using mutants and agents that disturb cell walls and membranes, we show that septins are involved in lipid metabolism and cell wall integrity signaling.

Summary: Ferroptosis, a unique form of lipotoxic cell death, is associated with macro-blebbing of trophoblast plasma membranes, likely representing thinning and enhanced membrane flexibility during cell death-associated swelling.


Summary: The lipophilic probes Nile Blue and Nile Red detect intracellular unsaturated free fatty acids and neutral lipids, respectively, and can be used for multiparametric imaging and flow cytometry.

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