Issues
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Cover image
Cover Image
Cover: Transverse sections showing the pharynx of the planarian Schmidtea mediterranea. The top image is a confocal section of a pharynx stained for the muscle marker 6G10 (red) and collagen-IV (green). Nuclei are counterstained using DAPI (blue). The bottom image is a rendering of the confocal section prepared using an edge detection algorithm in ImageJ, showing muscle (green), collagen-IV (red) and nuclei (DAPI, cyan). See article by V. K. Dubey, S. R. Sarkar et al. (jcs259900).
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RESEARCH HIGHLIGHTS
STICKY WICKET
MEETING REPORT
REVIEWS
The insect perspective on Z-disc structure and biology
Summary: The Z-disc is a massive and essential component of myofibrils. We use data from insects to present a comprehensive review of the assembly, components and functions of the Z-disc.
New insights into FAK structure and function in focal adhesions
Summary: This Review discusses the current structural understanding of one key regulator of the focal adhesion complex, focal adhesion kinase (FAK), and how it communicates with mechanical parts to promote cellular movement.
RESEARCH ARTICLES
Revisiting the significance of keratin expression in complex epithelia
Summary: An analysis of publicly available sc-RNAseq data from human and mouse epidermis to determine foundational principles and emerging paradigms regarding the significance of keratin gene expression.
The AHR target gene scinderin activates the WNT pathway by facilitating the nuclear translocation of β-catenin
Summary: The transcription factor AHR drives the expression of the actin-severing protein scinderin, which, in turn, promotes nuclear translocation of β-catenin, suggesting a novel mechanism by which AHR promotes growth of colon cancer cells.
Protein Phosphatase 2A with B′ specificity subunits regulates the Hippo-Yorkie signaling axis in the Drosophila eye disc
Highlighted Article: PP2A(B′) holoenzymes, in addition to STRIPAK, promote Yorkie activity by antagonizing Salvador-Rassf-Hippo signaling to maintain the morphology of the Drosophila eye disc epithelium.
MLL regulates the actin cytoskeleton and cell migration by stabilising Rho GTPases via the expression of RhoGDI1
Summary: MLL regulates cell shape, the actin cytoskeleton and cell migration by affecting the homeostasis of small Rho GTPases and plays a central regulatory role in Rho/Rac/CDC42 signalling pathways.
Non-autonomous cell death induced by the Draper phagocytosis receptor requires signaling through the JNK and SRC pathways
Highlighted Article: We identify signaling pathways activated by a phagocytosis receptor that induce cell death in neighboring cells.
S. mediterranea ETS-1 regulates the function of cathepsin-positive cells and the epidermal lineage landscape via basement membrane remodeling
Summary: ETS-1 regulates basement membrane remodeling and cathepsin cell population during planarian homeostasis and regeneration.
SHARPIN S146 phosphorylation mediates ARP2/3 interaction, cancer cell invasion and metastasis
Summary: We characterized SHARPIN phosphorylation by mass spectrometry and in vitro kinase assay. Our results identify S146 as a phosphorylation switch defining ARP2/3 interaction and cancer cell invasion.
FIRST PERSON
PUBLISHER'S NOTE
CORRECTION
Imaging Cell Architecture and Dynamics
We are still welcoming submissions for our upcoming Special Issue: Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: Lucy Collinson (The Francis Crick Institute, UK) and Guillaume Jacquemet (University of Turku, Finland). Extended submission deadline: 29 March 2024.
Journal of Cell Science - more than just a journal
People who know JCS well will know that we're more than just a journal and that our community – the cell biology community – really is at the heart of everything we do. Read the full Editorial by Editor-in-Chief Michael Way and Executive Editor Seema Grewal.
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