Issues

Summary: We provide a comprehensive review of the SNARE posttranslational modification literature, focusing on how these modifications can impact membrane traffic in a variety of contexts.

Summary: Spectrins are large proteins that form organized scaffolds in eukaryotic cells. This Review discusses the mechanical properties of spectrins, their organization in red blood cells and neurons, and the contribution to the mechanical properties of these cells.

Highlighted Article: Biochemical and live imaging analyses show that in mouse axons, Cox7c mRNA is associated and transported with mitochondria. Mutational analysis identifies mRNA domains essential for co-transport.

Highlighted Article: Fibronectin (Fn1) fibrils form when centripetally moving Fn1 nanodomains become organized into arrays. Fn1 fibrils are arrays of periodically spaced nanodomains containing multiple Fn1 dimers.

Highlighted Article: An ER-localized isoform of Arih2 regulates Smo synthesis to keep ciliary levels low at the basal state and maintain low levels of Hedgehog expression in the absence of ligand.

Summary: A complex interplay between host SUMO pathway genes and the AP-1 transcription factor during Salmonella infection fine-tunes the inflammatory mechanisms and pathogen survival.

Summary: Chemotactic signals that direct Dictyostelium movement for foraging and multicellular development act through an atypical MAPK to regulate the cellular distribution of a key developmental GATA transcription factor.

Summary: The oleaginous yeast Lipomyces starkeyi synchronized in G1 upon rapamycin treatment or nitrogen depletion efficiently produces and accumulates lipids. Cell cycle control is an attractive approach for industrial lipid production.

Summary: Knockout of Fchsd2 leads to stereocilia maintenance deficits and hearing loss in mice, suggesting that FCHSD2 is required for stereocilia maintenance in mouse cochlear hair cells.

Summary: A cortactin-dependent mechanism mediates disruption and dysfunction of epithelial barrier caused by respiratory syncytial virus infection.

Summary: Contractile tension at the actomyosin cortex is a key determinant of cell shape. Cortices from cells with high and low tension were analysed using mass spectrometry, generating a dataset of candidate cortex mechanics regulators.