Issues
-
Cover image
Cover Image
Cover: Structured illumination microscopy (SIM) image of a wild-type B16-F1 melanoma cell stimulated to migrate on laminin with hepatocyte growth factor in full growth medium. The cell was fixed, permeabilised and stained using fluorescently labelled phalloidin to visualise the F-actin cytoskeleton. Fluorescence intensities are colour-coded using the ImageJ Fire lookup table (ranging from high intensity in white to low intensity in black). See article by F. Kage et al. (jcs260364).
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
STICKY WICKET
OBITUARY
REVIEWS
Exploring cell and tissue mechanics with optical tweezers
Summary: Comprehensive description of optical tweezer experiments as used to study the importance of mechanical forces in cell biology and physiology.
The role of cellular quiescence in cancer – beyond a quiet passenger
Summary: We explore the concept of cancer as a disease that involves abnormal regulation of cellular quiescence at every step, from malignant transformation to metastatic outgrowth.
RESEARCH ARTICLES
Lamellipodia-like actin networks in cells lacking WAVE regulatory complex
Highlighted Article: Rac-dependent actin remodeling can occur in the absence of WAVE regulatory complex, triggered by active Cdc42. WAVE regulatory complex-independent actin structures harbor Arp2/3 complex but not VASP.
Redox-dependent AMPK inactivation disrupts metabolic adaptation to glucose starvation in xCT-overexpressing cancer cells
Summary: xCT-overexpressing cancer cells are highly vulnerable to glucose deprivation owing to a redox-dependent AMPK inactivation, leading to failure of metabolic adaptation.
N-acetylation of secreted proteins in Apicomplexa is widespread and is independent of the ER acetyl-CoA transporter AT1
Highlighted Article: Apicomplexan acetyl-CoA transporter 1 is indispensable for parasite development and transmission. This role is unrelated to the extensive acetylation of secreted proteins identified in apicomplexans.
Threonine phosphorylation regulates the molecular assembly and signaling of EGFR in cooperation with membrane lipids
Highlighted Article: Threonine phosphorylation at the juxtamembrane domain of EGFR is a critical step in shifting the role of EGFR from a kinase to a scaffold for signal transduction.
A transcriptionally repressed quiescence program is associated with paused RNA polymerase II and is poised for cell cycle re-entry
Summary: Promoter-proximal RNAPII stalling primes quiescent myoblasts for cell cycle re-entry. Surprisingly, Aff4, a component of the super elongation complex, is implicated in restraining the G0-G1 transition.
A Zn2+-triggered two-step mechanism of CLIC1 membrane insertion and activation into chloride channels
Summary: Identification of a two-step mechanism of CLIC1 membrane insertion based on Zn2+ binding and pH activation of Cl− efflux.
Metformin inactivates the cGAS-STING pathway through autophagy and suppresses senescence in nucleus pulposus cells
Summary: Metformin suppresses senescence via inactivating the cGAS-STING pathway through inducing autophagy, implying a new application for metformin in cGAS-STING pathway-related diseases.
Oncogenic gain of function due to p53 amyloids occurs through aberrant alteration of cell cycle and proliferation
Summary: p53 amyloid formation alters key cellular pathways to induce oncogenic traits leading to cellular transformation.
FIRST PERSON
PUBLISHER'S NOTE
PREPRINT HIGHLIGHTS
Introducing our new Editors
We welcome three new Editors to Journal of Cell Science - Robert Parton, Richa Rikhy and Simon Cook. You can read more about them in the Editorial from our Editor-in-Chief Michael Way.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Final registration deadline: 3 May 2024.
Workshop: Physics of the Early Embryonic Cell Divisions
Early-career researchers interested in the roles of nuclear lipids, apply now for one of the ten funded places at this Workshop, which will take place 11-14 November 2024. Application deadline: 17 May.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.
Propose a new Workshop for 2026
We are now accepting proposals for our 2026 Workshops programme. We aim to be responsive to the community and open to novel initiatives, so if you have a new idea for a biological workshop that you feel would work well, please apply. Applications deadline: 19 July 2024.