Issues

Summary: The role of the core ATG8 system during autophagosome formation and autophagosome-lysosome fusion.

Summary: Discussion of mitotic autophagy, focusing on the signalling pathways, selective macroautophagy and highlighting the role of mitotic lysosomes in macroautophagy-dependent and -independent processes.

Summary: We review state-of-the-art knowledge on the cellular functions and mechanisms of action of the proliferation marker Ki-67, as well as its roles in cancer.

Summary: The PDZ domain of Drosophila Dishevelled functions in noncanonical Wnt signalling but is dispensable for signalling through Armadillo, the fly homologue of β-catenin.

Summary: The biphasic regulatory role of ALKBH5 is mediated by its catalytic domain at both the early and late phase of somatic reprogramming.

Summary: TFK1, a novel basal body protein, is localized on the distal appendage matrix of transition fibres and is a critical key regulator of cytokinesis in the bloodstream form Trypanosoma brucei parasites.

Summary: DYRK2 promotes neddylation through forming a complex with NAE1 to maintain its protein level by suppressing polyubiquitylation, and thus is a regulator of genome stability.

Summary: There is a relationship between the age of the medulloblastoma patient and the developmental age of the tumor cell-of-origin, and this influences the SHH pathway signaling route used by the tumor.

Highlighted Article: A novel microtubule-regulating protein, named MTCL2, organizes an asymmetric array of microtubules by crosslinking them on the Golgi membrane.

Highlighted Article: The mechanism that regulates the subcellular distribution (focal adhesions versus flat clathrin lattices) of integrin β5 in keratinocytes is dependent on the level of tension, MARK2 and its preferred binding to the clathrin adaptors ARH and NUMB over talin.

Summary: VEGF-A controls the expression of its potent regulator of angiogenic functions, dopamine D2 receptors, on the endothelial cells via a crosstalk mediated by ERK1/2 signaling and KLF11.