Issues

Summary: This Review discusses the role of actin-binding protein profilin1 in major diseaeses with cardiovascular associations including atherosclerosis, hypertension and diabetes.

Summary: This Review describes lifetime imaging methodologies that are important for multiparameter 3D imaging of cells, tissues and small animals, with brief discussion of the underlying biosensing technologies.

Summary: Studies have uncovered multiple roles for SLK in various biological processes. We review the complex functions and regulation patterns of SLK in development and disease, that make it a potential therapeutic target.

Highlighted Article: The plasma membrane-associated Zdhhc5 enzyme enhances excitatory synapse formation in vitro and in vivo through motifs at its C-terminal domain.

Summary: An ancient glaucophyte c₆-like cytochrome related to cyanobacterial cytochromes c_6BC and higher plant c_6A is imported into muroplast thylakoids via the Sec pathway.

Summary: Loading of extracellular vesicle-derived miRNAs on recipient cell Ago2 occurs on endosomal membranes and is dependent on endosomal maturation and pH-driven cytosolic release of internalized miRNAs.

Highlighted Article: Identification of the upregulation of APP endocytosis as a mechanism used by normal neuronal aging to increase intracellular Aβ, contributing to aging-dependent synapse loss.

Highlighted Article: ZIC5 is SUMOylated in response to WNT signalling. This increases ZIC5 transcriptional activation but reduces ZIC5/TCF co-repression to promote neural crest specification throughout.

Summary: In mast cells, the scaffold protein RACK1 acts as a key hub in the arrangement of the actin cytoskeleton, impacting both store-operated Ca²⁺ entry and regulated secretion.

Summary: Reduced protein synthesis is required for stem cell functions. Here, we delineate a complex interplay of polyamines and mRNA translation that determines hair follicle stem cell fate decisions.

Summary: Mutagenic, expression and histological analyses reveal an essential role for miR-34b/c and miR-449 in multiciliogenesis in efferent ductules of the male reproductive tract by regulating cell cycle exit.

Highlighted Article: At the Drosophila glutamatergic neuromuscular junction (NMJ), a secreted, Ca²⁺-binding C-type lectin (Lectin-galC1) modulates synaptic transmission strength and resiliency by regulating synaptic vesicle cycle dynamics.

Summary: In addition to regulating peroxisome synthesis, the methanol sensor Wsc1 also regulates pexophagy through a downstream MAPK pathway that mediates phospho-regulation of the pexophagy receptor protein Atg30.

Summary: Fusion of monocytes to become bone-resorbing osteoclasts is limited by an SNX10-dependent cell-autonomous mechanism. Loss of SNX10 function deregulates fusion and generates giant inactive osteoclasts.