Issues

Summary: This Review discusses current understanding on the domain functions and biological roles of tensins in cells and mice as well as their contributions to disease development.

Summary: This Review discusses the formation and mechanisms of innate immune receptor clustering and how nanotechnologies have contributed to understanding the regulatory role of receptor clustering in innate immune cells.

Summary: This Review discusses the dynamics and function of F-actin and microtubules in syncytial Drosophila embryos with respect to tissue mechanics and self-organization processes.

Summary: Ipomoeassin-F blocks the Sec61-dependent translocation of SARS-CoV-2 proteins into and across the endoplasmic reticulum, highlighting the potential of Sec61 inhibitors as antiviral agents.

Highlighted Article: When ARID1B, an important component of the SWI/SNF chromatin remodeling complex, localizes to the cytoplasm, it exhibits a novel gain of oncogenic function.

Summary: Genome-wide screening identified a novel vacuolar protein, Tag1, responsible for termination of autophagy in yeast. Tag1 regulates autophagy termination via re-phosphorylation of Atg13 mediated by the Atg1 kinase.

Summary: Adenine nucleotide translocase protects Dictyostelium and human airway cells from cigarette smoke, promoting mitochondrial respiration, airway surface hydration and facilitating ciliary function.

Summary: Fibronectin, a major building block of tissues and organs, tunes fibroblast behavior and matrix architecture through the presence of alternatively spliced extra domains.

Summary: CELSR1 and CAMSAP3 are responsible for intercellular and intracellular basal body orientation, and their cooperation is critical for generating functional multi-ciliated epithelium in the mouse oviduct.

Highlighted Article: Live imaging of mitophagy reporter zebrafish shows mitophagy occurs via a piece-by-piece mechanism in vivo. Hypoxia induces mitophagy in muscle in a bnip3-dependent but pink1-independent manner.

Summary: We report the first identification of a nuclear localization signal for the meiotic recombination-promoting complex, the linear elements of fission yeast, related to the synaptonemal complex of other species.

Summary: Downregulation of icIL-1RA1 at the early stages of carcinogenesis can enable the development of a premature and deregulated senescence-associated secretory phenotype.

Summary: Prostate cancer cells have different sensitivities to fluid forces that alter their resistance to elevated blood flow-level fluid shear stress.

Summary: TPX2 regulates astral microtubules and spindle orientation. TPX2 is locally activated via the Golgi protein GM130 by sequestering importin α from TPX2, a process enabled by importin α phosphorylation at S62.

Summary: Expression level modulation of the core paraspeckle protein SFPQ regulates sense and antisense RNA foci and dipeptide repeat protein accumulation in the C9orf72 mutation; SFPQ could be a therapeutic target in C9orf72 ALS and FTD.

Highlighted Article: Physical interaction between serotonin receptor 5-HT₄ and adhesion molecule L1 facilitates ERK activation and modulates cofilin activity, regulating receptor-dependent maturation of synaptic connections.

Summary:PIK3CA^H1047R or PIK3CB expression induce distinct transformed phenotypes in MCF-10A cells; the transformed phenotype resulting from PIK3CB amplification depends on its unique interaction with Rac1.