CELL SCIENCE AT A GLANCE
Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones
Summary: Osteoclasts with low kindlin-3 expression fail to form tight sealing zones, showing that kindlin-3 is not only crucial for osteoclast adhesion to the bone surface but is also essential for the organization of adhesion structures.
A cytosolic reductase pathway is required for efficient N-glycosylation of an STT3B-dependent acceptor site
Summary: We show that the NADPH-dependent cytosolic reductive pathway influences glycosylation efficiency in the endoplasmic reticulum, linking cellular glucose metabolism to secretory glycoprotein heterogeneity.
Unfolding is the driving force for mitochondrial import and degradation of the Parkinson's disease-related protein DJ-1
Highlighted Article: Several mutations in Parkinson's disease-related protein DJ-1 cause its mitochondrial import and degradation. We reveal that protein unfolding is the driving force for the import and degradation of DJ-1.
Summary: A novel role of YAP1 in regulating the generation of mitochondrial ROS, and in modulating the protective effect of TERT against oxidative stress, could provide insights for the development of new therapies to treat gliomas.
Summary: A functional and reversible form of amyloid aggregation is conserved across the eukaryotic domain and helps cells survive severe environmental stressors.
Cooperation of membrane-translocated syntaxin4 and basement membrane for dynamic mammary epithelial morphogenesis
Highlighted Article: We report a novel regulatory model for epithelial morphogenesis: a t-SNARE extruded in response to lactogenic hormone acts coordinately with basement membrane components to trigger mammary cyst formation.
Summary: Stx17 is an ancient SNARE paralog, but has been lost in multiple lineages. Because of diverse structures in the C-terminal tail, Stx17 plays different roles in different organisms.
Highlighted Article: In motoneuron axonal growth cones, dynamic remodeling of the ER is coordinated through drebrin A-mediated actin and microtubule crosstalk and contributes to ribosome-dependent local translation in response to BDNF stimulation.
PQN-59 and GTBP-1 contribute to stress granule formation but are not essential for their assembly in C. elegans embryos
Summary: In contrast to human cells, where the UBAP2L and G3BP1 and G3BP2 proteins are crucial nucleators of stress granules, the C. elegans orthologs are not essential for this process in worms.