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RESEARCH HIGHLIGHTS

STICKY WICKET

FIRST PERSON

CELL SCIENTISTS TO WATCH

CELL SCIENCE AT A GLANCE

Summary: We provide a succinct and current view on the biology of Nck adaptors and their roles in key cellular processes, host–pathogen interactions, development, homeostasis and pathogenesis.

REVIEW

Summary: This Review details the role of α6β4 in hemidesmosome assembly and beyond, and discusses the molecular mechanisms that regulate α6β4 function.

RESEARCH ARTICLES

Highlighted Article: The decapping complex Dcp1–Dcp2 contains two nuclear localization signals. The ratio of cytoplasmic to nuclear localized Dcp1–Dcp2 is regulated by the P-body components Scd6 and Edc3 and the karyopherin Kap95.

Highlighted Article: We tracked junctional adhesion molecules (JAMs) with blocking or non-blocking antibodies to decipher how leukemic stem cells expressing JAM-C and displaying chemotherapy resistance interact with the stroma.

Highlighted Article: Analyses in yeast, mouse fibroblasts and human hepatic stellate cells revealed that active eIF5A is required for Col1a1 expression and could be a therapeutic target for fibrotic disease.

Summary: The small GTPase Rab7b bridges the lysosomal Ca2+ channel TRPML1 to myosin II, thus enabling the local activation of myosin II at the cell rear and promoting fast migration of dendritic cells.

Summary: The small GTPase Rho5 in the yeast Kluyveromyces lactis mediates oxidative stress response and takes part in the regulation of cytokinesis.

Highlighted Article: In vivo imaging in Chlamydomonas supports a simple model of intraflagellar transport (IFT) turnaround at the tip, in which IFT-A, -B, and IFT dynein remain associated and anterograde trains convert directly into retrograde trains.

Summary: We define the kinetics of intermediate activation of integrin αLβ2 by selectin. Cooperativity between selectin and integrin binding was evaluated by dose-response analysis, providing new insight into the signaling mechanism.

Summary: The insertion sequence 7 of titin is essential for titin function in the heart and might be indirectly involved in regulation of excitation–contraction coupling.

Summary: Nup50, which is localized in the nucleus of cardiomyocytes, selectively induces an increase in the transcription and translation of Kcna4.

Summary: PLP2, via its association with ZO-1, drives the collective cell migration of human colorectal cancer epithelium by modulating leading-edge actin cytoskeleton.

Summary: Mislocalization of the EGFR ligand EREG to the apical surface results in the formation of ectopic lumens in MDCK cysts in 3D cultures.

Summary: Dystrophic myofibers sustain pro-inflammatory macrophage status, which favors muscle damage and fibrosis. NaHS treatment dampens inflammation through AMPK activation, improving dystrophic muscle homeostasis.

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