Issues
-
Cover image
Cover Image
Cover: Transmission electron microscopy image of a cell with disrupted ER-to-Golgi trafficking following CRISPR-Cas9-mediated editing of MIA3/TANGO1. See article by J. McCaughey et al. (jcs259075)
- PDF Icon PDF LinkTable of contents
- PDF Icon PDF LinkIssue info
RESEARCH HIGHLIGHTS
EDITORIAL
STICKY WICKET
FIRST PERSON
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Prion protein and prion disease at a glance
Summary: We discuss latest progresses on prion protein and prion disease and highlight the emerging prionoid concept as well as the recent advances on the diagnosis and therapeutics of prion disease.
REVIEWS
Investigating the morphological dynamics of the plasma membrane by high-speed atomic force microscopy
Summary: A summary of recent advancements in live-cell imaging using high-speed atomic force microscopy, with a special emphasis on its application to morphological dynamics of the plasma membrane during endocytosis.
Links between autophagy and tissue mechanics
Summary: In addition to its well-known regulation by nutrients and hormones, autophagy occupies a central position in the integration of mechanical forces to contribute to tissue homeostasis.
RESEARCH ARTICLES
SUMOylation of RepoMan during late telophase regulates dephosphorylation of lamin A
Highlighted Article: Transient SUMOylation of RepoMan controls the recruitment of lamin A to telophase chromosomes, lamin A dephosphorylation and nuclear lamina formation.
A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function
Summary: TANGO1 is required to maintain the fundamental organization of the early secretory pathway in mammalian cells to support secretion of a diverse range of newly synthesized cargo proteins.
Phosphorylation of the AMPA receptor subunit GluA1 regulates clathrin-mediated receptor internalization
Summary: During synaptic plasticity to enhance synaptic strength, phosphorylation of AMPA receptor subunit GluA1 at serine 845 reduces receptor internalization by inhibiting interactions with endocytic proteins.
ADAR1 limits stress granule formation through both translation-dependent and translation-independent mechanisms
Summary: We report a novel, non-canonical role for ADAR1 as a negative regulator of stress granules that has implications for the role of ADAR1 in the antiviral response.
Activation of IRE1, PERK and salt-inducible kinases leads to Sec body formation in Drosophila S2 cells
Summary: In S2 cells, the phase-separated Sec bodies form upon the combined activation of salt-inducible kinases, IRE1 and PERK.
Lamin regulates the dietary restriction response via the mTOR pathway in Caenorhabditis elegans
Highlighted Article: Downregulation of the single C. elegans lamin gene increases animal size and fat content specifically in dietary restricted animals. The lamin protein acts in the mTOR pathway to regulate these phenotypes.
The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid–liquid phase separation
Highlighted Article: Liquid–liquid phase separation of oncogenic fusion proteins could be a potential mechanism for aberrant transcriptional activation.
Nuclear translocation of the tagged endogenous MAPK MPK-1 denotes a subset of activation events in C. elegans development
Highlighted Article: Tagged endogenous C. elegans MPK-1 shows activation-dependent cytosol-to-nuclear translocation. This tool provides novel insights into MPK-1 localization compared with other markers of in vivo ERK activation.
Enhanced RhoA signalling stabilizes E-cadherin in migrating epithelial monolayers
Summary: Contractile signaling promotes stabilization of E-cadherin to enforce orderly epithelial migration.
Phosphorylated cingulin localises GEF-H1 at tight junctions to protect vascular barriers in blood endothelial cells
Summary: Vascular leak in response to histamine, thrombin and VEGF can be counteracted by AMPK phosphorylating cingulin at its head domain. Consequential binding of GEF-H1 to tight junctions protects vascular barrier function.
TOOLS AND RESOURCES
Visualizing endogenous Rho activity with an improved localization-based, genetically encoded biosensor
Summary: The dT-2xrGBD location-based Rho biosensor relocalizes more efficiently than other sensors of this type, and this sensor enables the observation of endogenous Rho activity in cultured cells.
Introducing our new Editors
We welcome three new Editors to Journal of Cell Science - Robert Parton, Richa Rikhy and Simon Cook. You can read more about them in the Editorial from our Editor-in-Chief Michael Way.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Final registration deadline: 3 May 2024.
Workshop: Physics of the Early Embryonic Cell Divisions
Early-career researchers interested in the roles of nuclear lipids, apply now for one of the ten funded places at this Workshop, which will take place 11-14 November 2024. Application deadline: 17 May.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.
Propose a new Workshop for 2026
We are now accepting proposals for our 2026 Workshops programme. We aim to be responsive to the community and open to novel initiatives, so if you have a new idea for a biological workshop that you feel would work well, please apply. Applications deadline: 19 July 2024.