Issues

Summary: A discussion of the current structural understanding of the intraflagellar transport (IFT) and of how IFT trains function as macromolecular machines to assemble the structure of the cilium.

Summary: A review of recent studies that have shed light on the mechanisms of SUN–KASH interactions, their higher-order assembly, and the molecular mechanisms of force transfer across these complexes.

Summary: This Review discusses the contribution of myomiR network dysregulation to myogenic perturbations and muscle atrophy in ALS, as well as the potential for myomiRs as molecular targets of therapeutic strategies.

Summary: ECM stiffness-sensitive expression of lamellipodin promotes cellular stiffness, cyclin expression and cell proliferation in mouse embryonic fibroblasts.

Summary: Coilin, the Cajal body marker protein, plays an important role in the biogenesis of a microRNA, miR-210, that is responsive to hypoxia. The host gene for miR-210, MIR210HG, is alternatively spliced.

Summary: The central apparatus is essential for motility of ‘9+2’ cilia. The conserved proteins FAP70, FAP65 and FAP147 are components of the previously uncharacterized central apparatus projection C2a.

Summary: During cytokinesis, Rab11FIP1 localizes to the intercellular bridge where it maintains Rab35, which in turn removes the excess actin formed during membrane ingression thus promoting abscission.

Summary: RIPK2 forms dynamic complexes with erlin-1, erlin-2 and 14-3-3 proteins upon bacterial activation of NOD1.

Summary: The arrangement of the lamina in trypanosomatids has architectural differences to the metazoan system.

Summary: All three AMIGO family members act as auxiliary subunits of Kv2.1 and Kv2.2 K⁺ channels, and assembly of AMIGOs with either Kv2 improves AMIGO trafficking and alters channel function.

Summary: A functional RPA is indispensable for IGF-I-mediated keratinocyte rescue post-UVBR through the regulation of damage responses, cell cycle progression, photoproduct excision and survival pathways.

Summary: MicroRNAs of the miR-26 family trigger molecular events that are essential for neurogenesis by regulating the REST complex, setting in train a neuronal gene expression program.

Highlighted Article: The development of a software tool, SMorph, which performs automated morphometric analysis of cells in the brain. We show structural plasticity in astrocytes after antidepressant treatment.