Issues
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Cover image
Cover Image
Cover: ESC-derived postmitotic neurons on day 15 of differentiation, stained for Tubb3 (green). Nuclei are stained with DAPI (blue). Cells were transfected on day 9 of differentiation with microRNA negative control mimics. See article by M. Sauer et al. (jcs257535).
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RESEARCH HIGHLIGHTS
STICKY WICKET
FIRST PERSON
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
The structural basis of intraflagellar transport at a glance
Summary: A discussion of the current structural understanding of the intraflagellar transport (IFT) and of how IFT trains function as macromolecular machines to assemble the structure of the cilium.
REVIEWS
Molecular models of LINC complex assembly at the nuclear envelope
Summary: A review of recent studies that have shed light on the mechanisms of SUN–KASH interactions, their higher-order assembly, and the molecular mechanisms of force transfer across these complexes.
MyomiRs and their multifaceted regulatory roles in muscle homeostasis and amyotrophic lateral sclerosis
Summary: This Review discusses the contribution of myomiR network dysregulation to myogenic perturbations and muscle atrophy in ALS, as well as the potential for myomiRs as molecular targets of therapeutic strategies.
SHORT REPORTS
Mechanosensitive expression of lamellipodin promotes intracellular stiffness, cyclin expression and cell proliferation
Summary: ECM stiffness-sensitive expression of lamellipodin promotes cellular stiffness, cyclin expression and cell proliferation in mouse embryonic fibroblasts.
The Cajal body protein coilin is a regulator of the miR-210 hypoxamiR and influences MIR210HG alternative splicing
Summary: Coilin, the Cajal body marker protein, plays an important role in the biogenesis of a microRNA, miR-210, that is responsive to hypoxia. The host gene for miR-210, MIR210HG, is alternatively spliced.
RESEARCH ARTICLES
Chlamydomonas FAP70 is a component of the previously uncharacterized ciliary central apparatus projection C2a
Summary: The central apparatus is essential for motility of ‘9+2’ cilia. The conserved proteins FAP70, FAP65 and FAP147 are components of the previously uncharacterized central apparatus projection C2a.
Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission
Summary: During cytokinesis, Rab11FIP1 localizes to the intercellular bridge where it maintains Rab35, which in turn removes the excess actin formed during membrane ingression thus promoting abscission.
14-3-3 and erlin proteins differentially interact with RIPK2 complexes
Summary: RIPK2 forms dynamic complexes with erlin-1, erlin-2 and 14-3-3 proteins upon bacterial activation of NOD1.
A hub-and-spoke nuclear lamina architecture in trypanosomes
Summary: The arrangement of the lamina in trypanosomatids has architectural differences to the metazoan system.
Kv2 channel–AMIGO β-subunit assembly modulates both channel function and cell adhesion molecule surface trafficking
Summary: All three AMIGO family members act as auxiliary subunits of Kv2.1 and Kv2.2 K+ channels, and assembly of AMIGOs with either Kv2 improves AMIGO trafficking and alters channel function.
RPA facilitates rescue of keratinocytes from UVB radiation damage through insulin-like growth factor-I signalling
Summary: A functional RPA is indispensable for IGF-I-mediated keratinocyte rescue post-UVBR through the regulation of damage responses, cell cycle progression, photoproduct excision and survival pathways.
The miR-26 family regulates neural differentiation-associated microRNAs and mRNAs by directly targeting REST
Summary: MicroRNAs of the miR-26 family trigger molecular events that are essential for neurogenesis by regulating the REST complex, setting in train a neuronal gene expression program.
TOOLS AND RESOURCES
Automated morphometric analysis with SMorph software reveals plasticity induced by antidepressant therapy in hippocampal astrocytes
Highlighted Article: The development of a software tool, SMorph, which performs automated morphometric analysis of cells in the brain. We show structural plasticity in astrocytes after antidepressant treatment.
CORRECTION
Imaging Cell Architecture and Dynamics
We are still welcoming submissions for our upcoming Special Issue: Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: Lucy Collinson (The Francis Crick Institute, UK) and Guillaume Jacquemet (University of Turku, Finland). Extended submission deadline: 29 March 2024.
Journal of Cell Science - more than just a journal
People who know JCS well will know that we're more than just a journal and that our community – the cell biology community – really is at the heart of everything we do. Read the full Editorial by Editor-in-Chief Michael Way and Executive Editor Seema Grewal.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Submit your abstract by 5 April. Final registration deadline: 3 May 2024.
Workshop: Roles of Lipids in Nuclear Homeostasis and Genome Stability
Early-career researchers interested in the roles of nuclear lipids, apply now for one of the ten funded places at this Workshop, which will take place 14-17 October 2024. Application deadline: 19 April.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.