Issues
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Cover image
Cover Image
Cover: Stress granules (SGs) are liquid–liquid condensates seeded by RNA molecules and structured around ribonucleoprotein (RNP) complexes. They are formed in response to external stress and are sites of translation inhibition to conserve cellular energy. The image depicts an artist's conception of a SG core as a highly concentrated RNP mesh. The core is highly enriched in quiescent RNA that adopts A- and Z-conformations. Domains that recognize the Z-conformation of nucleic acids (Zα), such as those in ADAR1 p150 and DAI protein (shown in golden), translocate to the SGs alongside other RNP complexes. The image has been rendered with opensource PyMol and has made use of PDB structures 1J75, 4B3M and 4IIA. See article by Luisa Gabriel et al. (jcs258446).
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RESEARCH HIGHLIGHTS
FIRST PERSON
CELL SCIENCE AT A GLANCE
The multifunctional spindle midzone in vertebrate cells at a glance
Summary: A discussion of the roles of the spindle midzone, a microtubule-containing structure that connects the two half-spindles during mitosis, contributes to chromosome segregation and specifies the location of cytokinetic furrowing.
HYPOTHESIS
Dynein light intermediate chains as pivotal determinants of dynein multifunctionality
Summary: Spatiotemporally regulated posttranslational modifications of light intermediate chain subunits could modulate the diverse functional spectrum of cytoplasmic dynein through selective adaptor engagement.
REVIEW
Let's get physical – mechanisms of crossover interference
Summary: We survey mechanisms for regulating crossover interference during meiosis, and review how studies of phase separation, DNA repair and pan-nuclear signaling may resolve longstanding mysteries in the field.
SHORT REPORT
Spatial distribution of lamin A/C determines nuclear stiffness and stress-mediated deformation
Summary: The nuclear scaffold protein lamin A/C modulates nuclear stiffness, and heterogeneous lamin A/C density leads to diverse nuclear strain under stress.
RESEARCH ARTICLES
Organelle tethering, pore formation and SNARE compensation in the late endocytic pathway
Highlighted Article: Endocytic delivery to lysosomes by kiss and run/membrane fusion entails pore formation commencing at the edge of tether arrays, and demonstrates SNARE redundancy and compensation.
Self-organized optimal packing of kinesin-5-driven microtubule asters scales with cell size
Highlighted Article: Chemically induced MT asters interacting with kinesin-5 motors spontaneously form optimal packing patterns in vivo. A computational model reproduces the experimental patterns and predicts their scaling.
Integrity of the short arm of the nuclear pore Y-complex is required for mouse embryonic stem cell growth and differentiation
Highlighted Article: Seh1 and Nup43, although dispensable in pluripotent mouse ESCs, are required for normal cell growth, viability upon differentiation and maintenance of proper nuclear pore complex density.
Enrichment of Zα domains at cytoplasmic stress granules is due to their innate ability to bind to nucleic acids
Summary: We identify the interacting partners of the ZαβDAI–RNA complex in vivo and show that their translocation to stress granules is mainly mediated by the nucleic acid-binding ability of the Zα domains.
Identification of a heat-inducible novel nuclear body containing the long noncoding RNA MALAT1
Highlighted Article: The heat shock induces the translocation of long noncoding RNA MALAT1 from nuclear speckles to a heat-inducible noncoding RNA-containing nuclear body (HiNoCo body).
TORC2 inhibition of α-arrestin Aly3 mediates cell surface persistence of S. pombe Ght5 glucose transporter in low glucose
Summary: Nitrogen-dependent localization of S. pombe Ght5 on the cell surface is maintained by TORC2, which inhibits α-arrestin Aly3-dependent ubiquitylation and subsequent vacuolar translocation of Ght5.
Dissecting the PRSS37 interactome and potential mechanisms leading to ADAM3 loss in PRSS37-null sperm
Summary: PRSS37 interactome analysis showed that PRSS37 specifically modulates PDILT and ADAM3 interaction, which is a prerequisite for ADAM3 transport from the endoplasmic reticulum to the germ cell surface.
Hherisomes, Hedgehog specialized recycling endosomes, are required for high level Hedgehog signaling and tissue growth
Summary: Ultrastructural identification of specialized recycling endosomes that contain Hedgehog and sustain physiological Hedgehog activity for patterning and tissue growth in the wing disc.
Hijacking of the host cell Golgi by Plasmodium berghei liver stage parasites
Summary: Recruitment of the host cell Golgi by the parasitophorous vacuolar membrane of Plasmodium berghei is crucial for optimal pre-erythrocytic development. The interaction is accompanied by parasite-induced formation of miniaturized host cell Golgi.
Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19
Summary: An in-depth cellular and molecular characterization of myosin XIX (Myo19)-deficient cells reveals that different cellular and molecular processes are linked to mitochondrial dynamics regulated by Myo19.
Introducing our new Editors
We welcome three new Editors to Journal of Cell Science - Robert Parton, Richa Rikhy and Simon Cook. You can read more about them in the Editorial from our Editor-in-Chief Michael Way.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Final registration deadline: 3 May 2024.
Workshop: Physics of the Early Embryonic Cell Divisions
Early-career researchers interested in the roles of nuclear lipids, apply now for one of the ten funded places at this Workshop, which will take place 11-14 November 2024. Application deadline: 17 May.
Reasons to submit to Journal of Cell Science
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Propose a new Workshop for 2026
We are now accepting proposals for our 2026 Workshops programme. We aim to be responsive to the community and open to novel initiatives, so if you have a new idea for a biological workshop that you feel would work well, please apply. Applications deadline: 19 July 2024.