Issues

Summary: We discuss current understanding of the cytoplasmic dynein-2 microtubule motor, and its roles in cilia assembly and function.

Summary: A review of the roles of intermediate filaments and desmosomes in mechanobiology, highlighting their integration with other cytoskeletal and adhesive systems.

Highlighted Article: F-actin nucleation with Arp2/3 is triggered locally at each fusing insulin granule and controls granule dynamics and insulin secretion.

Highlighted Article: PTPN23 associates with BICD1 via its dynein-binding region, and its loss results in accumulation of neurotrophin receptors in enlarged, ubiquitylated sorting compartments.

Highlighted Article: Increased respiration is an innate, adaptive response to endoplasmic reticulum stress that is mediated by retrograde signaling and is independent of the unfolded protein response.

Summary: Two translation factor eIF4E isoforms are co-expressed in Caenorhabditis elegans germ cells but regulate distinct mRNAs, localize differently and promote different fates, oogenesis or spermatogenesis.

Summary: During Drosophila morphogenesis, the larval epithelial cells transit from migration to constriction. A change in the polarity of their pulsatile cytoskeletal network and tightly controlled cellular contractility underlie this transition.

Summary: Substrate trapping proteomics reveals that the ERAD rhomboid intramembrane protease RHBDL4 controls membrane protein complex assembly and abundance of the oligosaccharyltransferase complex.

Highlighted Article: Lamin plays a role in post-translational modification of plasma membrane proteins by tethering the GPI modification enzyme PIG-B to the inner nuclear membrane.

Highlighted Article: By controlling passive diffusion across the nuclear envelope, nuclear pore complexes regulate levels of the SAGA and SLIK coactivator complexes, suggesting alterations in passive diffusion can modulate gene expression.

Summary: Expression level of mitochondrial Ca²⁺ uniporter, a protein involved in intracellular Ca²⁺ regulation, influences glioblastoma cell proliferation, contributing to glioblastoma malignancy.

Summary: The loss of skeletal muscle function with age is related to the decrease in sarcoplasmic reticulum-stored Ca²⁺ in Drosophila.

Summary: Sts1 binds karyopherin α, and this complex associates preferentially with assembled 26S proteasomes, which degrade Sts1 without its prior ubiquitylation.

Summary: The molecular mechanism underlying A23187 triggered formation of actin foci in pollen tubes is uncovered, identifying villins as important players in this process via their roles in severing and bundling of actin filaments.

Summary: CDK19–CYC9 is an important regulator for sexual cell cycle initiation in T. thermophila, and mainly functions at the co-stimulation stage.

Highlighted Article: The ORP3 protein controls plasma membrane PI4P levels and store-operated Ca²⁺ entry regulated by protein kinase C at PM–ER contact sites.

Summary: Our results show that TAO kinases bind, phosphorylate and relocate Rnd3 to the cytosol, and that Rnd3 can contribute to mitotic cell rounding, spindle positioning and cytokinesis.

Summary: The endolysosomal protein CLN3 regulates the stability of lysosome sorting receptors, identifying a possible pathogenic mechanism to Batten disease.