Issues
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Cover image
Cover Image
Cover: Mitochondrially targeted GFP (mito–GFP, green) was used to visualise the mitochondrial dynamics in salivary gland cells dissected from a third instar Drosophila larva. Unlike the kidney-bean shape commonly seen in textbooks, mitochondria can be elongated and fused to form interconnected networks. DAPI was used to stain the polytene chromosomes (blue). See article by K. K. L. Wong et al. (jcs250944).
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RESEARCH HIGHLIGHTS
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CELL SCIENTISTS TO WATCH
REVIEWS
Extracellular vesicles – propagators of neuropathology and sources of potential biomarkers and therapeutics for neurodegenerative diseases
Summary: This Review highlights novel advancements in the involvement of small extracellular vesicles (EVs) as propagators of neuropathology, biomarkers and potential therapeutics in neurodegenerative diseases.
Forcing a growth factor response – tissue-stiffness modulation of integrin signaling and crosstalk with growth factor receptors
Summary: A Review of the mechanical tuning of growth factor signaling through crosstalk and interaction with mechanosensitive integrin cell adhesive receptors.
Recent insights into the regulatory networks of NLRP3 inflammasome activation
Summary: The NLRP3 inflammasome is a critical mediator of inflammation subject to dense regulatory networks to prevent erroneous inflammation. Here, we review recent advances into this exciting area of research.
SHORT REPORTS
Fission yeast Opy1 is an endogenous PI(4,5)P2 sensor that binds to the phosphatidylinositol 4-phosphate 5-kinase Its3
Summary: The fission yeast dual PH domain-containing protein Opy1 binds PI(4,5)P2 and senses this lipid in the plasma membrane. Unlike related proteins, Opy1 binds but does not regulate phosphatidylinositol 4-phosphate 5-kinase.
Cdc48 regulates intranuclear quality control sequestration of the Hsh155 splicing factor in budding yeast
Summary: We report the localization and function of the Cdc48 chaperone at intranuclear protein quality control sites in yeast, where it regulates the stability of the Hsh155 splicing factor.
RESEARCH ARTICLES
Changes in subcellular structures and states of pumilio 1 regulate the translation of target Mad2 and cyclin B1 mRNAs
Summary: An aggregation–dissolution model for the temporal and spatial control of mRNA translation is found for Pum1-mediated control in mouse oocytes.
Blockage of bone morphogenetic protein signalling counteracts hypertrophy in a human osteoarthritic micro-cartilage model
Summary: Inhibition of BMP signalling by targeting ALK2 and ALK3 reduces OA hypertrophic features in an OA micro-cartilage model, while maintaining the capacity of the cells to produce cartilage-specific proteins.
Dopamine D1 receptor stimulates cathepsin K-dependent degradation and resorption of collagen I in lung fibroblasts
Summary: Dopamine receptor D1 agonism promotes degradation of collagen I in lung fibroblasts by enhancing cathepsin K expression and activation.
Ssc-miR-21-5p regulates endometrial epithelial cell proliferation, apoptosis and migration via the PDCD4/AKT pathway
Highlighted Article: Expression and mutagenic analyses demonstrated that ssc-miR-21-5p impedes PDCD4 and, therefore, the phosphorylation of AKT which affected the functions of endometrial epithelial cells.
Hyperpolarized mitochondria accumulate in Drosophila Hipk-overexpressing cells to drive tumor-like growth
Summary: Altered mitochondrial energetics plays a more decisive role than morphology in determining tumor-like growth in a fly tumor model caused by elevated Homeodomain-interacting protein kinase.
SMARCA2 is regulated by NORFA–miR-29c, a novel pathway that controls granulosa cell apoptosis and is related to female fertility
Summary: SMARCA2, a candidate gene for sow reproductive traits, controls porcine granulosa cell apoptosis and is regulated by the NORFA–miR-29c signaling pathway, a novel regulatory pathway associated with female fertility.
RAS-mediated suppression of PAR3 and its effects on SCC initiation and tissue architecture occur independently of hyperplasia
Highlighted Article: Temporal analysis of human neoplasia identifies PAR3 as a critical regulator of E-cadherin-mediated cell adhesion and oriented cell division during initial human SCC development.
AGS3-dependent trans-Golgi network membrane trafficking is essential for compaction in mouse embryos
Summary: AGS3 activates Gαi1 and results in the transport of TMED7-positive cargo containing Cdh1 to the cell-contact surface by reinforcing the dynamic trans-Golgi network in the early mouse embryo.
Aurora B and C kinases regulate chromosome desynapsis and segregation during mouse and human spermatogenesis
Highlighted Article: Homologous chromosomes recombine and synapse during meiotic prophase. Aurora kinase B and C are important to coordinate chromosome desynapsis and segregation during mouse and human spermatogenesis.
Introducing our new Editors
We welcome three new Editors to Journal of Cell Science - Robert Parton, Richa Rikhy and Simon Cook. You can read more about them in the Editorial from our Editor-in-Chief Michael Way.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Final registration deadline: 3 May 2024.
Workshop: Physics of the Early Embryonic Cell Divisions
Early-career researchers interested in the roles of nuclear lipids, apply now for one of the ten funded places at this Workshop, which will take place 11-14 November 2024. Application deadline: 17 May.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.
Propose a new Workshop for 2026
We are now accepting proposals for our 2026 Workshops programme. We aim to be responsive to the community and open to novel initiatives, so if you have a new idea for a biological workshop that you feel would work well, please apply. Applications deadline: 19 July 2024.