Molecular basis for KDEL-mediated retrieval of escaped ER-resident proteins – SWEET talking the COPs
Summary: The structure of the KDEL receptor gives new insights into the close connection between trafficking and transport in the cell.
Summary: Current evidence suggests conserved but separate roles of Ras and PI3K in the direct activation of mTORC2, implicating the regulation of distinct cellular mTORC2 pools downstream of different stimuli.
Callose deposition is essential for the completion of cytokinesis in the unicellular alga Penium margaritaceum
Highlighted Article: Callose deposition during cytokinesis is important for cell wall formation. There is a conserved role for callose at the division plane between P. margaritaceum, a unicellular Charophyte, and land plants.
Integration of JAK/STAT receptor–ligand trafficking, signalling and gene expression in Drosophila melanogaster cells
Highlighted Article: Compartmentalised signalling along the endocytic pathway regulates expression of JAK/STAT targets. This suggests a mechanism by which a single ligand can give rise to different signalling outputs.
Topical insulin application accelerates diabetic wound healing by promoting anti-inflammatory macrophage polarization
Summary: Overexpression of insulin-degrading enzyme leads to low insulin levels in diabetic wounds, resulting in dysfunction of neutrophils and macrophages. Supplying insulin promotes wound healing by inducing anti-inflammatory macrophage polarization.
Highlighted Article: Cooperation between cargo binding and interaction with other endocytic coat proteins is essential for adaptor protein recruitment to the membrane.
Highlighted Article: Regulation of caveolae by the F-BAR protein PACSIN2 is dependent on the plasma membrane cholesterol level.
Summary: Direct interactions of the acidic F1 loop motif of talin with the juxtamembrane domains of integrin activate the β3 integrin heterodimer.
Invariant chain regulates endosomal fusion and maturation through an interaction with the SNARE Vti1b
Summary: Invariant chain (CD74) interacts with the SNARE Vti1b. This interaction is essential for invariant chain to delay endosomal maturation, thereby creating a pathway for slower antigen processing and antigen loading.
Amalgam regulates the receptor tyrosine kinase pathway through Sprouty in glial cell development in the Drosophila larval brain
Highlighted Article: Employing single-cell RNA-seq uncovered that Amalgam affects receptor tyrosine kinase signaling and the blood–brain barrier during glia development and in a glioma model in Drosophila.
The centriole protein CEP76 negatively regulates PLK1 activity in the cytoplasm for proper mitotic progression
Summary: The centriole protein CEP76 is essential for the proper regulation of PLK1 in the cytoplasm to prevent its aberrant activation during mitosis.