Issues

Summary: The structure of the KDEL receptor gives new insights into the close connection between trafficking and transport in the cell.

Summary: Current evidence suggests conserved but separate roles of Ras and PI3K in the direct activation of mTORC2, implicating the regulation of distinct cellular mTORC2 pools downstream of different stimuli.

Highlighted Article: Callose deposition during cytokinesis is important for cell wall formation. There is a conserved role for callose at the division plane between P. margaritaceum, a unicellular Charophyte, and land plants.

Highlighted Article: Compartmentalised signalling along the endocytic pathway regulates expression of JAK/STAT targets. This suggests a mechanism by which a single ligand can give rise to different signalling outputs.

Summary: Overexpression of insulin-degrading enzyme leads to low insulin levels in diabetic wounds, resulting in dysfunction of neutrophils and macrophages. Supplying insulin promotes wound healing by inducing anti-inflammatory macrophage polarization.

Highlighted Article: Cooperation between cargo binding and interaction with other endocytic coat proteins is essential for adaptor protein recruitment to the membrane.

Highlighted Article: Regulation of caveolae by the F-BAR protein PACSIN2 is dependent on the plasma membrane cholesterol level.

Summary: Direct interactions of the acidic F1 loop motif of talin with the juxtamembrane domains of integrin activate the β3 integrin heterodimer.

Summary: Invariant chain (CD74) interacts with the SNARE Vti1b. This interaction is essential for invariant chain to delay endosomal maturation, thereby creating a pathway for slower antigen processing and antigen loading.

Highlighted Article: Employing single-cell RNA-seq uncovered that Amalgam affects receptor tyrosine kinase signaling and the blood–brain barrier during glia development and in a glioma model in Drosophila.

Summary: The centriole protein CEP76 is essential for the proper regulation of PLK1 in the cytoplasm to prevent its aberrant activation during mitosis.