Issues

Summary: A review of the signaling cascades regulating and regulated by the different isoforms of the p53-related transcription factor p63, as well the role of p63 in disease.

Summary: Microautophagy is a versatile and conserved type of autophagy. Here, recent progress is reviewed that allows fission-type and fusion-type microautophagy to be distinguished, thus providing a new conceptual framework.

Summary: In this Review we provide an overview of the early secretory pathway protein RER1, which cycles between cis-Golgi and ER, returning ER-resident proteins and unassembled subunits of multimeric complexes back to the ER.

Highlighted Article: Using GFP-tagged β-tubulin, we show that most of the tubulin required for axonemal assembly enters Chlamydomonas cilia by diffusion rather than by intraflagellar transport.

Highlighted Article: A regulatory circuit maintaining intracellular amino acid homeostasis is revealed by studies of yeast growing under high hydrostatic pressure, with a critical role identified for the EGOC–Pib2–TORC1 complex.

Summary: In fission yeast, sexual differentiation is important for survival in environmental changes. We found that Pef1 regulates initiation of sexual differentiation through control of the TORC1 pathway and autophagy.

Summary: Inflammatory responses require leukocyte migration along the vascular wall. We show that signaling from β2, but not β1, integrins induces cytoskeletal changes needed for upstream migration under shear flow.

Highlighted Article: Fe65 is a major intracellular APP-binding protein. We show that Fe65 is a transcription factor, whose nuclear translocation and thus transcriptional capacity is regulated by APP cleavage.

Summary: The ER–mitochondria tether maintained by MFN2 fine-tunes Rac activation to regulate neutrophil adhesive migration and adhesion to endothelial cells under shear stress.

Summary: The interaction of the signal integrators AGS3 and DVL2 is regulated by protein phosphorylation, subcellular distribution, and a cell-surface G-protein-coupled receptor.

Summary: The α-tubulin acetyltransferase αTAT1 is involved in DNA damage checkpoints and DNA repair through its acetyltransferase activity.

Summary: Cancer cells subjected to compressive stress experience frustration of clathrin-mediated endocytosis which, in turn, leads to enhanced receptor signaling.

Summary: The BRCA1-interacting protein RACK1 regulates centriole duplication by acting as a scaffold protein for the phosphorylation of polo-like kinase 1 by Aurora A.