Issues
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Cover image
Cover Image
Cover: Airyscan confocal image of a HeLa cell infected with Shigella flexneri, which are forming actin tails. Bacterial DNA is shown in orange, SEPT7 in green and F-actin in red. Shigella MreB helps to position IcsA to form actin tails (highlighted with a ‘fire’ look-up table to reflect signal intensity). Image taken by Ana Teresa López Jiménez. See article by Sina Krokowski et al. (jcs.226217).
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RESEARCH HIGHLIGHTS
JCS PRIZE
FIRST PERSON
CELL SCIENTISTS TO WATCH
REVIEWS
Engineering the cellular mechanical microenvironment – from bulk mechanics to the nanoscale
Summary: A review of the different techniques that can be applied to recapitulate the mechanical complexity of the cellular microenvironment and how these substrates have been used to gain new insights into mechanobiology.
Role of septins in microbial infection
Summary: This Review illustrates how studying septin biology during microbial infection can provide fundamental advances in both cell and infection biology, and suggests new concepts underlying infection control.
SHORT REPORTS
ArhGEF37 assists dynamin 2 during clathrin-mediated endocytosis
Summary: Accumulation of ArhGEF37 at dynamin 2-rich late endocytic sites yields increased rates of endocytosis.
Shigella MreB promotes polar IcsA positioning for actin tail formation
Summary: The pathogen Shigella forms actin tails to move through the cytosol of infected cells. We show that the bacterial actin homologue MreB can help to position the autotransporter protein IcsA for such actin tail formation.
Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a
Summary: Rab3GEP plays an important, but not exclusive, role in organelle targeting of Rab27a, and the Rab3GEP DENN domain alone is insufficient to activate and target Rab27a.
RESEARCH ARTICLES
The N-end rule pathway and Ubr1 enforce protein compartmentalization via P2-encoded cellular location signals
Summary: The N-end rule pathway and Ubr1 enforce the compartmentalization of secretory and mitochondrial proteins through the recognition of cellular location signals embedded into the P2 residues of most proteins.
Sexual dimorphism, estrous cycle and laterality determine the intrinsic and synaptic properties of medial amygdala neurons in rat
Highlighted Article: The intrinsic properties and synaptic inputs of posterodorsal medial amygdala neurons (classified as Class I and II) in rat are modulated by sex, estrous cycle and hemispheric lateralization.
Crosstalk of PD-1 signaling with the SIRT1/FOXO-1 axis during the progression of visceral leishmaniasis
Summary: Leishmania parasites regulate PD-1 signaling through the SIRT1/FOXO-1 axis to inhibit host cell apoptosis to allow infection establishment during early and late phases of infection.
Evidence for a regulated Ca2+ entry in proximal tubular cells and its implication in calcium stone formation
Highlighted Article: Proximal tubular Ca2+ regulation is enigmatic. We identified a regulated Ca2+ entry in PT cells resulting in CaP crystal formation, which could be the rate-limiting step to prevent calcium stone formation.
XMAP215 promotes microtubule–F-actin interactions to regulate growth cone microtubules during axon guidance in Xenopus laevis
Highlighted Article: XMAP215 binds F-actin in vitro and promotes microtubule–F-actin alignment in growth cones, which could be controlling cytoskeletal dynamics downstream of guidance cues, and thus, steering the axon during neuronal development.
Cortical mitochondria regulate insulin secretion by local Ca2+ buffering in rodent beta cells
Highlighted Article: In rodent beta cells, cortical F-actin rearrangements control the density of a cortical pool of mitochondria, which, in turn, regulates insulin secretion through local Ca2+ buffering.
TOOLS AND RESOURCES
New quantitative approach reveals heterogeneity in mitochondrial structure–function relations in tumor-initiating cells
Summary: We designed the mito-SinCe2 method to quantitatively analyze states of mitochondrial dynamics and energetics in single cells. Mito-SinCe2 analyses reveal energetic complexity in tumor-initiating cells.
PUBLISHER'S NOTE
CORRECTION
Imaging Cell Architecture and Dynamics
We are still welcoming submissions for our upcoming Special Issue: Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: Lucy Collinson (The Francis Crick Institute, UK) and Guillaume Jacquemet (University of Turku, Finland). Extended submission deadline: 29 March 2024.
Journal of Cell Science - more than just a journal
People who know JCS well will know that we're more than just a journal and that our community – the cell biology community – really is at the heart of everything we do. Read the full Editorial by Editor-in-Chief Michael Way and Executive Editor Seema Grewal.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Submit your abstract by 5 April. Final registration deadline: 3 May 2024.
Workshop: Roles of Lipids in Nuclear Homeostasis and Genome Stability
Early-career researchers interested in the roles of nuclear lipids, apply now for one of the ten funded places at this Workshop, which will take place 14-17 October 2024. Application deadline: 19 April.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.