Issues
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Cover image
Cover Image
Cover: Retinal pigment epithelial (RPE-1) cell on a crossbow-shaped micropattern. It was fixed with paraformaldehyde and immunostained with primary antibodies against α-actinin (green) and fluorescently labelled phalloidin (magenta) to reveal actin filaments. See article by F. Senger et al. (jcs236604).
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RESEARCH HIGHLIGHTS
FIRST PERSON
CELL SCIENCE AT A GLANCE
The liquid nucleome – phase transitions in the nucleus at a glance
Summary: This Cell Science at a Glance article discusses how membrane-less compartments in the nucleus are formed by phase separation and help to organize and regulate nuclear functions.
REVIEW
Multiscale dynamics of tight junction remodeling
Summary: This Review discusses how tight junction remodeling at multiple scales contributes to sustained epithelial barrier function in the face of cell and tissue dynamics.
SHORT REPORTS
A homeostatic mechanism rapidly corrects aberrant nucleocytoplasmic ratios maintaining nuclear size in fission yeast
Summary: Nuclear size homeostasis is achieved by a rapid correction mechanism modulating nuclear growth rate in growing fission yeast cells.
Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration
Summary: Yap regulates, in a non-cell-autonomous manner, Bmp signalling activation in osteoprogenitors, thereby promoting osteoblast differentiation and proper bone formation during zebrafish caudal fin regeneration.
MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium
Highlighted Article: A pool of centriolar γ-tubulin and/or α/β-tubulins anchor MICAL-L1 to the centriole, where it might recruit EHD1 to promote ciliogenesis.
RESEARCH ARTICLES
Condensin II protein dysfunction impacts mitochondrial respiration and mitochondrial oxidative stress responses
Highlighted Article: Condensin II proteins localize to mitochondria, and their depletion results in defects in oxygen consumption rates, changes in ATP levels and inefficient mitochondrial responses to oxidative stress.
Two conserved glycine residues in mammalian and Dictyostelium Rictor are required for mTORC2 activity and integrity
Summary: Two glycine residues are essential for the mTORC2 activity and integrity in organisms that are distantly related, suggesting they have a conserved role in mTORC2 assembly and functioning.
Role for the splicing factor TCERG1 in Cajal body integrity and snRNP assembly
Highlighted Article: The results suggest a new role for TCERG1 in the formation of Cajal bodies and the biogenesis of snRNPs, which may have a functional consequence for pre-mRNA processing.
Vac8 spatially confines autophagosome formation at the vacuole in S. cerevisiae
Highlighted Article: Vac8 tethers the phagophore assembly site to the vacuole, which creates a confined space for autophagosome biogenesis and coordinates autophagosome formation with vacuolar fusion.
Spatial integration of mechanical forces by α-actinin establishes actin network symmetry
Highlighted Article: In the absence of α-actinin, a cross-linker of actin filaments, the symmetry of the cellular actin architecture is no longer in accordance with the geometry of extracellular cues.
PREPRINT HIGHLIGHTS
JCS Journal Meeting 2023: Imaging Cell Dynamics

Our 2023 Journal Meeting on ‘Imaging Cell Dynamics’ will be held from 14-17 May 2023 in Lisbon, Portugal. We have a limited number of spaces left so sign up now! Registration deadline: 31 March.
Call for papers: Cell and Tissue Polarity
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We are welcoming submissions for our next special issue, which will focus on ‘Cell and tissue polarity’ and will be guest edited by David Bryant. Submission deadline: 15 July.
Webinar: Increasing the visibility and impact of your research
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Would you like to increase the visibility and impact of your research and raise your profile internationally? If so, register for the very practical webinar we are running in association with HUBS on 23 February 2023.
Cell scientist to watch: Gautam Dey

We interviewed Gautam Dey, who became a group leader at EMBL in Heidelberg, Germany, in 2021. His lab investigates the fundamental organisational principles and evolutionary dynamics of the nuclear compartment across eukaryotes.
Mechanisms of eukaryotic transcription termination at a glance

Check out our latest Cell Science at a Glance article and accompanying poster for an overview of the current understanding about the mechanisms of transcription termination by the three eukaryotic RNAPs.