Issues

Summary: This Cell Science at a Glance article discusses how membrane-less compartments in the nucleus are formed by phase separation and help to organize and regulate nuclear functions.

Summary: This Review discusses how tight junction remodeling at multiple scales contributes to sustained epithelial barrier function in the face of cell and tissue dynamics.

Summary: Nuclear size homeostasis is achieved by a rapid correction mechanism modulating nuclear growth rate in growing fission yeast cells.

Summary: Yap regulates, in a non-cell-autonomous manner, Bmp signalling activation in osteoprogenitors, thereby promoting osteoblast differentiation and proper bone formation during zebrafish caudal fin regeneration.

Highlighted Article: A pool of centriolar γ-tubulin and/or α/β-tubulins anchor MICAL-L1 to the centriole, where it might recruit EHD1 to promote ciliogenesis.

Highlighted Article: Condensin II proteins localize to mitochondria, and their depletion results in defects in oxygen consumption rates, changes in ATP levels and inefficient mitochondrial responses to oxidative stress.

Summary: Two glycine residues are essential for the mTORC2 activity and integrity in organisms that are distantly related, suggesting they have a conserved role in mTORC2 assembly and functioning.

Highlighted Article: The results suggest a new role for TCERG1 in the formation of Cajal bodies and the biogenesis of snRNPs, which may have a functional consequence for pre-mRNA processing.

Highlighted Article: Vac8 tethers the phagophore assembly site to the vacuole, which creates a confined space for autophagosome biogenesis and coordinates autophagosome formation with vacuolar fusion.

Highlighted Article: In the absence of α-actinin, a cross-linker of actin filaments, the symmetry of the cellular actin architecture is no longer in accordance with the geometry of extracellular cues.