CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Summary: A Review of recent developments in understanding the major cell-autonomous stress-responsive transcriptional regulatory pathways, including the activation of enhancers and complex changes in chromatin organization.
Summary: Talin requires cooperative Rap1 binding to its F0 and F1 domains and lipid binding to the F2 domain for its recruitment to adhesion sites to trigger integrin activation.
Summary: After prolonged quiescence, fission yeast cell populations switch state to immobilise subcellular components much more profoundly than cells experiencing acute energy depletion.
P-cadherin-induced decorin secretion is required for collagen fiber alignment and directional collective cell migration
Highlighted Article: P-cadherin-induced decorin expression allows collagen fiber alignment and subsequent activation of the β-PIX/Cdc42 axis to promote directional collective cell migration.
Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1
Highlighted Article: Phospho-regulation of the INCENP STD motif acts as a novel switch that is key to Aurora B activity modulation, chromosome alignment and cytokinesis.
Cul3 regulates cyclin E1 protein abundance via a degron located within the N-terminal region of cyclin E
Highlighted Article: Cyclin E is targeted by Cul3 for proteasomal degradation via a newly identified degron located within the N-terminal domain of cyclin E, a region that is often missing in cancer cells.
Summary: GRASP55 is highly acetylated on lysine 50 during mitosis, and its deacetylation by SIRT2 at mitotic exit promotes Golgi assembly through facilitating GRASP55 self-interaction.
TOOLS AND RESOURCES
Highlighted Article: Functionalized GFP-binding nanobodies (dongles) can extend the use of GFP-tagged proteins. Here, dongles that allow knocksideways are demonstrated, but they are limited by perturbation of the target protein caused by dongle binding alone.
Summary: An easy dry-ice-free method of sending cultured cells across the globe at ambient temperatures.