Issues

Summary: Review of the controversial cilia mechanotransduction hypothesis, by providing different facts that support and oppose this hypothesis.

Summary: This paper reviews literature related to nuclear membrane mechanics and its importance in envelope function.

Summary: Apparent accumulation of PIP₂ and cortex/polarity-related proteins within plasma membrane microdomains in polarizing C. elegans zygotes reflects local membrane topology induced by filopodia, not selective enrichment within signaling domains.

Summary: cAMP efflux by MRP4 (ABCC4) has a critical role in controlling PKA activity and its effectors, as well as Ca²⁺ levels, thus affecting the fertilizing ability of mouse spermatozoa.

Summary: SUMO conjugation regulates dynamic protein localisation in the central spindle during female meiosis I in Caenorhabditis elegans.

Summary: The conserved exocytic vesicle-tethering exocyst complex and the endocytic master regulator Rab5 mutually interact and are required to deliver the ESCRT III membrane scission apparatus for completion of cytokinesis.

Highlighted Article: Survivin interacts with myosin II regulating myosin II filament assembly. This interaction occurs during telophase, is regulated by Cdk1 and the dimerization state of survivin, and is required for cytokinesis.

Highlighted Article: For mammalian epithelial cells to divide in the correct orientation and form normal luminal structures, Dlg1 must localise to the cell cortex, which is dependent on binding to CASK.

Highlighted Article: Tau associates with SHP2, a protein tyrosine phosphatase that is involved in cancer. Tau–SHP2 complexes, regulated by tau phosphorylation, appear during neuronal development and in Alzheimer's disease samples.

Summary: Comparison of the cellular responses to different TGF-β family ligands reveals distinct signalling dynamics driven by receptor localisation, which may underlie their biological function.

Summary: Mitochondrial NCKX5 plays a key role in regulating melanogenesis through organelle interaction, which is implicated in processes leading to formation of gray hair and hypopigmented lesions in vitiligo patients.

Summary: The quiescent and differentiated state of Sertoli cells during spermatogenesis depends on negative regulation of E2F3 by retinoblastoma protein, which maintains cell cycle exit and terminal differentiation.

Summary: The hook complex-associated protein BOH1 functions upstream of the Polo-like kinase to regulate flagellum inheritance and cytokinesis initiation in Trypanosoma brucei.