Cover: A complex set of cellular mechanisms regulates the balance between healthy muscle tissue (red, left) and muscles in which a loss of muscle maintenance causes tissuedegeneration (right). See article by N. Green et al. (jcs217943).
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Mechanical forces in cell monolayers
Summary: The transmission of mechanical signals through cellular assemblies regulates collective cell behavior.
Unite to divide – how models and biological experimentation have come together to reveal mechanisms of cytokinesis
Summary: Biological experimentation and modeling have advanced our understanding of various cell behaviors. We provide a primer for biologists on several modeling strategies and highlight how modeling has revealed cytokinetic mechanisms.
Glycosphingolipid metabolism in cell fate specification
Summary: Glycosphingolipids are emerging as powerful determinants in differentiation events. Here, we review the existing literature on the role of glycosphingolipids in cell fate determination.
FLCN is a novel Rab11A-interacting protein that is involved in the Rab11A-mediated recycling transport
Summary: FLCN regulates the Rab11A-mediated recycling transport pathway.
A tissue communication network coordinating innate immune response during muscle stress
Summary: Activation of Drosophila innate immune responses is coordinated at local and systemic levels through tissue crosstalk following disruptions to muscle homeostasis.
Direct binding of Talin to Rap1 is required for cell–ECM adhesion in Drosophila
Summary: The small GTPase Rap1 binds directly to the F0 domain of Talin allowing its recruitment to integrins at the plasma membrane. This process appears to be strictly required for integrin-mediated adhesion in Drosophila.
Gli2 modulates cell cycle re-entry through autophagy-mediated regulation of the length of primary cilia
Summary: Gli2 knockout in fibroblasts lengthens primary cilia through enhanced autophagy-mediated Ofd1 degradation. This ciliary lengthening delays cell cycle re-entry – an unexpected mechanism for cell cycle regulation.
ADAR2-mediated Q/R editing of GluK2 regulates kainate receptor upscaling in response to suppression of synaptic activity
Highlighted Article: Synaptic suppression promotes proteasomal degradation of the mRNA-editing enzyme ADAR2. Decreased ADAR2 levels reduce Q/R editing of the kainate receptor subunit GluK2 leading to enhanced surface expression and homeostatic upscaling of GluK2-containing KARs.
Lack of G1/S control destabilizes the yeast genome via replication stress-induced DSBs and illegitimate recombination
Summary: Absence of G1/S control in the budding yeast swi6Δ mutant leads to cell death due to replication stress and subsequent DSBs. Rad51 helps to repair breaks, but causes DNA rearrangements.
SHP-2 is activated in response to force on E-cadherin and dephosphorylates vinculin Y822
Summary: Here, we employ a novel technique to manipulate phosphatases, revealing a mechanism for how force transmission is switched off or reset.
Bexarotene – a novel modulator of AURKA and the primary cilium in VHL-deficient cells
Highlighted Article: An image-based screen using a dual labeling strategy identified bexarotene, a rexinoid, as a novel modulator of the primary cilium in VHL-deficient cells.
Cullin-3–KCTD10-mediated CEP97 degradation promotes primary cilium formation
Highlighted Article: CEP97 degradation mediated by the CUL3–RBX1–KCTD10 E3 ubiquitin ligase is crucial for serum-starvation-induced CP110 removal and ciliogenesis.
An interaction network between the SNARE VAMP7 and Rab GTPases within a ciliary membrane-targeting complex
Summary: Two Rab proteins and a Rab GEF provide a ‘cradle’ for the longin SNARE VAMP7 mediating its incorporation into prebudding complex at the Golgi/TGN during sensory receptor ciliary trafficking.
JCS Journal Meeting 2023: Imaging Cell Dynamics
Our 2023 Journal Meeting on ‘Imaging Cell Dynamics’ will be held from 14-17 May 2023 in Lisbon, Portugal. Due to popular demand, we can currently only accept applications for online attendance. Apply now to attend this meeting virtually. Registration deadline: 31 March.
Call for papers: Cell and Tissue Polarity
We are welcoming submissions for our next special issue, which will focus on ‘Cell and tissue polarity’ and will be guest edited by David Bryant. Submission deadline: 15 July.
Editorial: Publishing where it matters
Editor-in-Chief Michael Way outlines Journal of Cell Science’s plans for the upcoming year and introduces Seema Grewal as our new Executive Editor.
preLights 5th Birthday webinar
preLights, our preprint highlighting service, is celebrating its 5th birthday this year. To mark the occasion, join us online on 14 March 2023 at 16:00 GMT for a discussion, led by four preLights alumni, on how to identify and navigate the challenges and opportunities while shaping your career as an early-career researcher.
Cell Scientists to Watch
As a community-focused journal, Journal of Cell Science is keen to support the next generation of cell biologists. Check out Cell Scientists to Watch, our interview series featuring talented researchers who have recently set up their own labs.