Issues

Summary: Organelles are subjected to mechanical forces within the crowded cytoplasm of eukaryotic cells. We discuss the effect of forces on two organelles, the nucleus and the mitochondrion.

Summary: Here, we review the functions of the multifunctional SQSTM1 (p62) protein based on its post-translational modifications, as well as how its deregulation is involved in multiple human diseases.

Summary: Delineation of the molecular components of stem cell mechanotransduction responsible for mechanically-induced osteogenesis, revealing potential mechanotherapeutics for bone pathologies.

Summary: Dynamic changes of polymerized actin in specific regions of mouse sperm undergoing acrosomal exocytosis are revealed by super-resolution microscopy.

Highlighted Article: During T cell activation, a cytoskeletal pool of ADAP enters nascent contacts in advance of other adaptors and enhances contact stability and TCR signaling by participating in multivalent signaling complexes.

Summary: Rab34 is required for an early step of ciliary vesicle formation and Hedgehog signaling in vivo.

Summary: TM9SF4 interacts with a variety of transmembrane domains (TMDs) and facilitates their transport from the endoplasmic reticulum to the Golgi complex. TM9SF4 levels modulate transport of TMDs in the early secretory pathway in different cell types.

Highlighted Article: This article highlights several molecular mechanisms that result in the assembly of integrin αVβ5-containing flat clathrin lattices in human keratinocytes.

Summary: Lack of IL15RA causes ultrastructural changes in muscle mitochondrial cristae to support the energy demand associated with increased activity.

Summary: Both formins and ENA/VASP proteins mediate filopodial assembly. In U2OS cells, the formin FMNL3 functions at filopodial tips, whereas ENA/VASP proteins may influence filopodia at focal adhesions.

Highlighted Article: The cancer-related tetraspanin protein CD151 uses novel pathways to mediate the regulation of FGFR2 expression.

Summary: Removal of CAMSAP3, a protein that binds the microtubule minus-ends, promotes epithelial-to-mesenchymal transition in lung cancer-derived cells via enhancement of tubulin acetylation and Akt activation.