Cover: From top left down each column, electron micrograph of a subsarcolemmal mitochondrion at 100,000 × magnification and images obtained by applying a mirror filter with an increasing number of reflection planes (0, top left; 1, center left; 3, bottom left; 5, top center; 7, center; 10, bottom center; 12, top right; 15, center right; and 20, bottom right). See article by E. Loro et al. (jcs218313).
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Mechanical forces on cellular organelles
Summary: Organelles are subjected to mechanical forces within the crowded cytoplasm of eukaryotic cells. We discuss the effect of forces on two organelles, the nucleus and the mitochondrion.
p62/SQSTM1 – steering the cell through health and disease
Summary: Here, we review the functions of the multifunctional SQSTM1 (p62) protein based on its post-translational modifications, as well as how its deregulation is involved in multiple human diseases.
Mesenchymal stem cell mechanotransduction is cAMP dependent and regulated by adenylyl cyclase 6 and the primary cilium
Summary: Delineation of the molecular components of stem cell mechanotransduction responsible for mechanically-induced osteogenesis, revealing potential mechanotherapeutics for bone pathologies.
Super-resolution imaging of live sperm reveals dynamic changes of the actin cytoskeleton during acrosomal exocytosis
Summary: Dynamic changes of polymerized actin in specific regions of mouse sperm undergoing acrosomal exocytosis are revealed by super-resolution microscopy.
ADAP is an upstream regulator that precedes SLP-76 at sites of TCR engagement and stabilizes signaling microclusters
Highlighted Article: During T cell activation, a cytoskeletal pool of ADAP enters nascent contacts in advance of other adaptors and enhances contact stability and TCR signaling by participating in multivalent signaling complexes.
Rab34 small GTPase is required for Hedgehog signaling and an early step of ciliary vesicle formation in mouse
Summary: Rab34 is required for an early step of ciliary vesicle formation and Hedgehog signaling in vivo.
TM9SF4 levels determine sorting of transmembrane domains in the early secretory pathway
Summary: TM9SF4 interacts with a variety of transmembrane domains (TMDs) and facilitates their transport from the endoplasmic reticulum to the Golgi complex. TM9SF4 levels modulate transport of TMDs in the early secretory pathway in different cell types.
Mechanisms of integrin αVβ5 clustering in flat clathrin lattices
Highlighted Article: This article highlights several molecular mechanisms that result in the assembly of integrin αVβ5-containing flat clathrin lattices in human keratinocytes.
Mitochondrial ultrastructural adaptations in fast muscles of mice lacking IL15RA
Summary: Lack of IL15RA causes ultrastructural changes in muscle mitochondrial cristae to support the energy demand associated with increased activity.
Roles for Ena/VASP proteins in FMNL3-mediated filopodial assembly
Summary: Both formins and ENA/VASP proteins mediate filopodial assembly. In U2OS cells, the formin FMNL3 functions at filopodial tips, whereas ENA/VASP proteins may influence filopodia at focal adhesions.
CD151 regulates expression of FGFR2 in breast cancer cells via PKC-dependent pathways
Highlighted Article: The cancer-related tetraspanin protein CD151 uses novel pathways to mediate the regulation of FGFR2 expression.
Loss of CAMSAP3 promotes EMT via the modification of microtubule–Akt machinery
Summary: Removal of CAMSAP3, a protein that binds the microtubule minus-ends, promotes epithelial-to-mesenchymal transition in lung cancer-derived cells via enhancement of tubulin acetylation and Akt activation.
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