Issues
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Cover image
Cover Image
Cover: Cysts formed by MDCKΔGal3 cells show defects in organization and develop multiple small lumens or tubes. Cells were cultured in Matrigel for 7 days and polarity of cysts analysed by confocal microscopy. Cysts are stained for β-catenin (green) and gp135 (red). Nuclei are stained blue with Hoechst 33342. See article by E. Hönig et al. (jcs213199).
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RESEARCH HIGHLIGHTS
FIRST PERSON
CELL SCIENCE AT A GLANCE
Plasmodesmata at a glance
Summary: This Cell Science at a Glance article summarizes how plasmodesmata are dynamic and multifaceted nanochannels that bridge neighboring plant cells.
REVIEW
Common signalling pathways in macrophage and osteoclast multinucleation
Summary: This Review highlights the common signalling pathways in macrophage and osteoclast multinucleation. This basic cell phenomenon which underlies various complex diseases is poorly understood.
SHORT REPORT
CCAR-1 affects hemidesmosome biogenesis by regulating unc-52/perlecan alternative splicing in the C. elegans epidermis
Summary: Loss of CCAR-1 function during C. elegans embryogenesis results in dysregulated alternative splicing of unc-52 (the homolog of mammalian perlecan) and hemidesmosome disruption.
Studying meiotic cohesin in somatic cells reveals that Rec8-containing cohesin requires Stag3 to function and is regulated by Wapl and sororin
Summary: Rec8-mediated cohesion is reconstituted in a somatic cell line and shown to chiefly depend on co-expression of Stag3. Rec8–Stag3-containing cohesin is antagonised by Wapl and protected by sororin.
Melanopsin (Opn4) utilizes Gαi and Gβγ as major signal transducers
Summary: In addition to its canonical pathway, the photoreceptor melanopsin (Opn4) signals through G proteins βγ and αi and controls several major signaling pathways, which may explain its multi-functionality.
RESEARCH ARTICLES
Tricellular junction proteins promote disentanglement of daughter and neighbour cells during epithelial cytokinesis
Highlighted Article: Daughter-neighbour cell disentanglement during multicellular cytokinesis is driven by the coordinated basal descent of the midbody and de novo assembly of tricellular septate junctions.
Role of Kip2 during early mitosis – impact on spindle pole body separation and chromosome capture
Summary: In S. cerevisiae, the length of cytoplasmic microtubule is kept short by Kip2p function during G1-S phase to allow for separation of SPBs and proper chromosome capture.
Proteasome stress leads to APP axonal transport defects by promoting its amyloidogenic processing in lysosomes
Summary: Proteasome inhibition induces rapid and significant reductions of APP axonal transport towards synapses due to increased cell body amyloidogenic processing of APP in lysosomes.
ARF6 protects sister chromatid cohesion to ensure the formation of stable kinetochore-microtubule attachments
Summary: The GTPase ARF6 protects sister chromatid cohesion, allowing the establishment of stable kinetochore-microtubule attachments, SAC satisfaction and mitotic progression.
The actin cytoskeleton of the mouse sperm flagellum is organized in a helical structure
Summary: The actin and actin-associated protein structures in the sperm tail are revealed by means of STORM. In particular, actin forms a double helix in the midpiece, a novel architectural organization in eukaryotic cells.
Lipid droplet consumption is functionally coupled to vacuole homeostasis independent of lipophagy
Highlighted Article: A genome-wide screen in budding yeast reveals that the functional status of vacuoles is relayed to lipid droplets to regulate their efficient utilization, independently of lipophagy.
BMPR2 inhibits activin and BMP signaling via wild-type ALK2
Summary: Activation of SMAD1/5/8 via endogenous wild-type ALK2 by activin A, activin B and certain BMPs is enhanced when BMPR2 levels are knocked down.
Galectin-3 modulates the polarized surface delivery of β1-integrin in epithelial cells
Highlighted Article: The lectin galectin-3 redistributes β1-integrins and elevates their apical cell surface delivery to promote accurate tubulocyst formation.
SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS
Summary: Misfolded SOD1 contributes to ubiquitin proteasome system dysfunction in a cell model of ALS. Hence, ubiquitin homeostasis is an important marker of changes in ALS pathology.
Retromer associates with the cytoplasmic amino-terminus of polycystin-2
Highlighted Article: Transient receptor potential channel polycystin-2 (PC2) associates with the endosomal sorting complex retromer in a manner that appears to be required for trafficking of PC1 to cilia.
IL1β and TNFα promote RANKL-dependent adseverin expression and osteoclastogenesis
Summary: Pro-inflammatory cytokines IL1β and TNFα promote RANKL-dependent adseverin expression and osteoclastogenesis. A novel method for isolating osteoclast subpopulations based on ploidy status was developed.
TOOLS AND RESOURCES
Microtubules as platforms for probing liquid–liquid phase separation in cells – application to RNA-binding proteins
Summary: Confining RNA-binding proteins on microtubules allows analysis of the mixing and demixing of coexisting RNA-rich sub-compartments with liquid-like properties in living cells.
Imaging Cell Architecture and Dynamics
We are still welcoming submissions for our upcoming Special Issue: Imaging Cell Architecture and Dynamics. This issue will be coordinated by two Guest Editors: Lucy Collinson (The Francis Crick Institute, UK) and Guillaume Jacquemet (University of Turku, Finland). Extended submission deadline: 29 March 2024.
Journal of Cell Science - more than just a journal
People who know JCS well will know that we're more than just a journal and that our community – the cell biology community – really is at the heart of everything we do. Read the full Editorial by Editor-in-Chief Michael Way and Executive Editor Seema Grewal.
2024 Journal Meeting 'Diversity and Evolution in Cell Biology'
Registration is open for our 2024 Journal Meeting Diversity and Evolution in Cell Biology, which aims to bring together evolutionary biologists and cell biologists investigating diverse aspects of cellular physiology. Submit your abstract by 5 April. Final registration deadline: 3 May 2024.
Workshop: Roles of Lipids in Nuclear Homeostasis and Genome Stability
Early-career researchers interested in the roles of nuclear lipids, apply now for one of the ten funded places at this Workshop, which will take place 14-17 October 2024. Application deadline: 19 April.
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.