IN THIS ISSUE
CELL SCIENTISTS TO WATCH
CELL SCIENCE AT A GLANCE
Highlighted Article: Neuropilin 1 is a co-receptor for PDGF-D, but not PDGF-B, in PDGFRβ signaling. This may represent a new and important aspect in the biology of NRP1 and PDGF-D.
Summary: Endocytosis is a vital process in most cells, and here we identify important proteins required for this process in trypanosomes. Significantly, these are unique and not present in animals, fungi or plants.
Highlighted Article: Coupled with CRMP1, Nav1.7 plays a role in mediating retrograde Semaphorin 3A signaling, highlighting its function in signaling from the nerve growth cone to cell body.
Summary: Kinetochore–microtubule interactions are essential for faithful chromosome segregation. Here, we describe consequences of GSK3 phosphorylation-site mutations that control CLASP2 interactions with microtubules during mitosis.
Highlighted Article: This study reveals a new role of proline dehydrogenase in p53-dependent cellular senescence and raises the possibility that an alteration in amino acid metabolism can promote the senescence process.
Summary: The trafficking systems of trypanosomes are shown to vary considerably, with much minimisation in systems with antigenic variation and more complexity in cell invasive forms.
Neuronal hyperactivity causes Na+/H+ exchanger-induced extracellular acidification at active synapses
Highlighted Article: A novel extracellular pH-indicator that is sensitive to acidic shifts reveals that neuronal hyperactivity causes acidic shifts that are localized to active synapses and generated by the Na+/H+ exchanger.
The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking
Summary: The retinal degeneration gene product CCDC66 is a microtubule-associated protein that localizes to the centrosome and cilium complex, and functions in cilium formation and recruitment of BBS4 to the cilium.
Summary: In vitro and in vivo experiments demonstrate that the two TEX19 paralogs belong to the family of piRNA-interacting proteins.
Missing-in-metastasis protein downregulates CXCR4 by promoting ubiquitylation and interaction with small Rab GTPases
Summary: MIM promotes CXCR4 ubiquitylation by interacting with AIP4; this interaction is also required for CXCR4 sorting into multivesicular bodies, which is linked to MIM acting as an effector of Rab small GTPases.
Oxidative stress elicited by modifying the ceramide acyl chain length reduces the rate of clathrin-mediated endocytosis
Summary: Altering sphingolipid acyl chain length causes oxidative stress, reducing transcription of Hsc70 via Sp1, which leads to lower levels of Hsc70-mediated uncoating of clathrin-coated vesicles.