IN THIS ISSUE
CELL SCIENCE AT A GLANCE
Different functional modes of BAR domain proteins in formation and plasticity of mammalian postsynapses
Summary: A review of recent insights into the postsynaptic functions of BAR domain proteins. It is proposed that these proteins have four general, not mutually exclusive, functional modes.
Highlighted Article: Binding of SGTA to the proteasome delays substrate degradation, thereby providing a mechanism for potentially viable proteins to be rescued for reuse.
Summary: A characterization of how an intronic miRNA encoded in the dynamin genes controls cellular endocytosis by targeting multiple components of the endocytic machinery.
Cooperative interactions of LPPR family members in membrane localization and alteration of cellular morphology
Highlighted Article: This paper presents the results of a large-scale proteome analysis to determine LPPR1-interacting proteins and identifies a functional cooperation between LPPR family members.
Summary: Tumor protein D52 (TPD52) increases lipid droplet numbers and fatty acid incorporation into triglyceride, possibly through relevant functions at both the Golgi complex and lipid droplets.
The Drosophila retinoblastoma protein, Rbf1, induces a Debcl- and Drp1-dependent mitochondrial apoptosis
Highlighted Article: Debcl, a Drosophila pro-apoptotic Bcl-2 family member, can induce mitochondrial fragmentation by binding the pro-fission protein Drp1, which induces mitochondrial ROS accumulation, JNK pathway activation and cell death.
Summary: 14-3-3 might directly bind to CD13, which transmits a signal in chondrocytes to induce a catabolic phenotype similar to that observed in osteoarthritis.
Highlighted Article: The SNAREs STX13 and VAMP7 mutually regulate their localization in melanocytes and control the cargo delivery to the melanosome during its biogenesis.
Centrosomal AKAP350 and CIP4 act in concert to define the polarized localization of the centrosome and Golgi in migratory cells
Summary: The present study establishes the participation of AKAP350 and CIP4 in centrosome positioning in migratory cells, and demonstrates the direct connection between the two cytoskeletal regulatory proteins in this process.
Characterization of Cep85 – a new antagonist of Nek2A that is involved in the regulation of centrosome disjunction
Summary: Cep85 acts as a binding partner of Nek2A to prevent premature centrosome separation in interphase by inhibiting Nek2A activity.
Dictyostelium Nramp1, which is structurally and functionally similar to mammalian DMT1 transporter, mediates phagosomal iron efflux
Summary: The Dictyostelium Nramp1 transporter confers resistance to pathogenic bacteria by mediating iron efflux from phagosomes. Nramp1 and the related NrampB (formerly Nramp2) display differences in metal selectivity, electrogenicity and H+ dependence.
Summary: TRPC6 regulates metabolism to affect HIF-1α stability and consequent glucose metabolism in human glioma cells under hypoxia.
RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction
Summary: RDGB regulates PtdIns and PtdIns(4,5)P2 homeostasis during G-protein-activated phospholipase C signalling in Drosophila.
Summary: Our data demonstrate that the expression of periostin is stimulated by the ErbB ligand NRG1 and promotes the migration of Schwann cell precursors.