Cover: Confocal image of a Drosophila eye/antennal imaginal disc bearing GFP-labeled clones (green), of cells expressing active Ras and simultaneously lacking the tumor suppressor Scribble and the Filamin A homolog, Cheerio (stained in magenta). Removal of the actin crosslinker Cheerio from the tumor cells does not prevent accumulation of filamentous actin (white) but reduces malignancy of the tumors, causing them to become rounded and sorted away from the neighboring epithelium. See article by Külshammer and Uhlirova (pp. 927–938).
- PDF Icon PDF LinkTable of contents
CELL SCIENCE AT A GLANCE
Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance
The endocannabinoid N-arachidonoyl glycine (NAGly) inhibits store-operated Ca2+ entry by preventing STIM1–Orai1 interaction
Poly(ADP-ribosyl)ation links the chromatin remodeler SMARCA5/SNF2H to RNF168-dependent DNA damage signaling
Role of connexins in metastatic breast cancer and melanoma brain colonization
Large heterogeneity of mitochondrial DNA transcription and initiation of replication exposed by single-cell imaging
The actin cross-linker Filamin/Cheerio mediates tumor malignancy downstream of JNK signaling
NBR1 acts as an autophagy receptor for peroxisomes
PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2–ERK1/2–p90RSK and AKT signaling pathways
Analysis of the ‘angulin’ proteins LSR, ILDR1 and ILDR2 – tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis
MicroRNA-17-92a upregulation by estrogen leads to Bim targeting and inhibition of osteoblast apoptosis
Identification of a novel motif that affects the conformation and activity of the MARCH1 E3 ubiquitin ligase
RARγ is essential for retinoic acid induced chromatin remodeling and transcriptional activation in embryonic stem cells
CXCL12–CXCR4 signaling is required for the maintenance of mouse spermatogonial stem cells
The dynamin-binding domains of Dap160/intersectin affect bulk membrane retrieval in synapses
Roles of chemokine receptor CX3CR1 in maintaining murine bone homeostasis through the regulation of both osteoblasts and osteoclasts
IN THIS ISSUE
ARTICLE OF INTEREST IN OTHER COB JOURNALS
Cbx4 regulates the proliferation of thymic epithelial cells and thymus function
Reasons to submit to Journal of Cell Science
There are many benefits to publishing in Journal of Cell Science - read more about why you should choose JCS or visit our submission page now.
Call for papers: Cell and Tissue Polarity
We are welcoming submissions for our next special issue, which will focus on ‘Cell and tissue polarity’ and will be guest edited by David Bryant. Submission deadline: 15 July.
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Journal of Cell Science a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
Propose a new Workshop for 2025
Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
FocalPlane Image Competition 2023
FocalPlane’s 2023 image competition is underway, in celebration of the community site’s third birthday. Click here for submission details and information on how to showcase your favourite image.