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Volume 125, Issue 2

January 2012

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Cover image

Cover Image

Cover: Ubiquitylation regulates numerous cellular functions, including autophagy. Shown here are MCF-7 breast adenocarcinoma cells, stably expressing a GFP-tagged autophagy receptor (green), that have been subjected to amino acid starvation plus bafilomycin A1 treatment to maximise autophagy flux and block substrate degradation. Cells were stained with antibodies against the early endosomal antigen-1 (EEA1) (blue) and p62 (SQSTM1) (red). For an overview of different ubiquitin functions, see our Minifocus starting on page 249. Image: David G. McEwan and Ivan Dikic, University of Frankfurt Medical School.
Table of contents

ISSN 0021-9533

EISSN 1477-9137

In this issue

STICKY WICKET
CELL SCIENCE AT A GLANCE
COMMENTARY
SHORT REPORT
RESEARCH ARTICLE
ARTICLE OF INTEREST IN OTHER COB JOURNALS
- FROM DEVELOPMENT
IN THIS ISSUE

STICKY WICKET

Priests and Clowns

Mole

Extract

View articletitled, Priests and Clowns

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CELL SCIENCE AT A GLANCE

Ubiquitin and SUMO in DNA repair at a glance

Helle D. Ulrich

Extract

View articletitled, Ubiquitin and SUMO in DNA repair at a glance

Supplementary information

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COMMENTARY

Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control

Annamaria Mocciaro,Michael Rape

Abstract

View articletitled, Emerging regulatory mechanisms in ubiquitin-dependent cell cycle control

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The role of ubiquitylation in receptor endocytosis and endosomal sorting

Kaisa Haglund,Ivan Dikic

Abstract

View articletitled, The role of ubiquitylation in receptor endocytosis and endosomal sorting

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Cellular functions of the DUBs

Michael J. Clague,Judy M. Coulson,Sylvie Urbé

Abstract

View articletitled, Cellular functions of the DUBs

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SHORT REPORT

Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish

Mirko Völkers,Nima Dolatabadi,Natalie Gude,Patrick Most,Mark A. Sussman,David Hassel

Abstract

View articletitled, Orai1 deficiency leads to heart failure and skeletal myopathy in zebrafish

Supplementary information

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RESEARCH ARTICLE

Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells

Bilal N. Sheikh,Mathew P. Dixon,Tim Thomas,Anne K. Voss

Abstract

View articletitled, Querkopf is a key marker of self-renewal and multipotency of adult neural stem cells

Supplementary information

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Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin

Shu-Chin Yip,Sophie Cotteret,Jonathan Chernoff

Abstract

View articletitled, Sumoylated protein tyrosine phosphatase 1B localizes to the inner nuclear membrane and regulates the tyrosine phosphorylation of emerin

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Lateral spacing of adhesion peptides influences human mesenchymal stem cell behaviour

Jessica E. Frith,Richard J. Mills,Justin J. Cooper-White

Abstract

View articletitled, Lateral spacing of adhesion peptides influences human mesenchymal stem cell behaviour

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Dynamics within tetraspanin pairs affect MHC class II expression

Tineke van den Hoorn,Petra Paul,Lennert Janssen,Hans Janssen,Jacques Neefjes

Abstract

View articletitled, Dynamics within tetraspanin pairs affect MHC class II expression

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Mammalian erythroblast enucleation requires PI3K-dependent cell polarization

Junxia Wang,Tzutzuy Ramirez,Peng Ji,Senthil Raja Jayapal,Harvey F. Lodish,Maki Murata-Hori

Abstract

View articletitled, Mammalian erythroblast enucleation requires PI3K-dependent cell polarization

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Interconnected contribution of tissue morphogenesis and the nuclear protein NuMA to the DNA damage response

Pierre-Alexandre Vidi,Gurushankar Chandramouly,Matthew Gray,Lei Wang,Er Liu,Joseph J. Kim,Vassilis Roukos,Mina J. Bissell,Prabhas V. Moghe,Sophie A. Lelièvre

Abstract

View articletitled, Interconnected contribution of tissue morphogenesis and the nuclear protein NuMA to the DNA damage response

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Direct role of Bardet–Biedl syndrome proteins in transcriptional regulation

Cecilia Gascue,Perciliz L. Tan,Magdalena Cardenas-Rodriguez,Gabriela Libisch,Tamara Fernandez-Calero,Yangfan P. Liu,Soledad Astrada,Carlos Robello,Hugo Naya,Nicholas Katsanis,Jose L. Badano

Abstract

View articletitled, Direct role of Bardet–Biedl syndrome proteins in transcriptional regulation

Supplementary information

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Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells

Jiewei Liu,Kun Xu,Maya Chase,Yuxin Ji,Jennifer K. Logan,Rachel J. Buchsbaum

Abstract

View articletitled, Tiam1-regulated osteopontin in senescent fibroblasts contributes to the migration and invasion of associated epithelial cells

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A dual role for Rac1 GTPases in the regulation of cell motility

Vedrana Filić,Maja Marinović,Jan Faix,Igor Weber

Abstract

View articletitled, A dual role for Rac1 GTPases in the regulation of cell motility

Supplementary information

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CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster

Elena Domanitskaya,Trudi Schüpbach

Abstract

View articletitled, CoREST acts as a positive regulator of Notch signaling in the follicle cells of <em>Drosophila melanogaster</em>

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Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function

Jan H. Bergmann,Julia N. Jakubsche,Nuno M. Martins,Alexander Kagansky,Megumi Nakano,Hiroshi Kimura,David A. Kelly,Bryan M. Turner,Hiroshi Masumoto,Vladimir Larionov,William C. Earnshaw

Abstract

View articletitled, Epigenetic engineering: histone H3K9 acetylation is compatible with kinetochore structure and function

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Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages

David Bartolomé-Martín,Jorge Ramírez-Franco,Enrique Castro,José Sánchez-Prieto,Magdalena Torres

Abstract

View articletitled, Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages

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Induction of membrane circular dorsal ruffles requires co-signalling of integrin–ILK-complex and EGF receptor

S. Babak Azimifar,Ralph T. Böttcher,Sara Zanivan,Carsten Grashoff,Marcus Krüger,Kyle R. Legate,Matthias Mann,Reinhard Fässler

Abstract

View articletitled, Induction of membrane circular dorsal ruffles requires co-signalling of integrin–ILK-complex and EGF receptor

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Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling

Hiroshi Sakane,Hideki Yamamoto,Shinji Matsumoto,Akira Sato,Akira Kikuchi

Abstract

View articletitled, Localization of glypican-4 in different membrane microdomains is involved in the regulation of Wnt signaling

Supplementary information

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GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis

Shuoshuo Wang,Heiko Meyer,Amanda Ochoa-Espinosa,Ulf Buchwald,Susanne Önel,Benjamin Altenhein,Jürgen J. Heinisch,Markus Affolter,Achim Paululat

Abstract

View articletitled, GBF1 (Gartenzwerg)-dependent secretion is required for Drosophila tubulogenesis

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Flow cytometry analysis reveals a decrease in intracellular sodium during sperm capacitation

Jessica Escoffier,Dario Krapf,Felipe Navarrete,Alberto Darszon,Pablo E. Visconti

Abstract

View articletitled, Flow cytometry analysis reveals a decrease in intracellular sodium during sperm capacitation

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GCP6 is a substrate of Plk4 and required for centriole duplication

Ramona Bahtz,Joerg Seidler,Marc Arnold,Uta Haselmann-Weiss,Claude Antony,Wolf D. Lehmann,Ingrid Hoffmann

Abstract

View articletitled, GCP6 is a substrate of Plk4 and required for centriole duplication

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Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling

Hira Lal Goel,Bryan Pursell,Clive Standley,Kevin Fogarty,Arthur M. Mercurio

Abstract

View articletitled, Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling

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Autophagy plays an essential role in the clearance of Pseudomonas aeruginosa by alveolar macrophages

Kefei Yuan,Canhua Huang,John Fox,Donna Laturnus,Edward Carlson,Binjie Zhang,Qi Yin,Hongwei Gao,Min Wu

Abstract

View articletitled, Autophagy plays an essential role in the clearance of <em>Pseudomonas aeruginosa</em> by alveolar macrophages

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Mob1: defining cell polarity for proper cell division

Alexandra Tavares,João Gonçalves,Cláudia Florindo,Álvaro A. Tavares,Helena Soares

Abstract

View articletitled, Mob1: defining cell polarity for proper cell division

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ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity

William P. Daley,Elise M. Gervais,Samuel W. Centanni,Kathryn M. Gulfo,Deirdre A. Nelson,Melinda Larsen

View articletitled, ROCK1-directed basement membrane positioning coordinates epithelial tissue polarity

A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos

Allison R. Morckel,Hrvoje Lusic,Laila Farzana,Jeffrey A. Yoder,Alexander Deiters,Nanette M. Nascone-Yoder

View articletitled, A photoactivatable small-molecule inhibitor for light-controlled spatiotemporal regulation of Rho kinase in live embryos

IN THIS ISSUE

Email alerts

Accepted manuscripts alert

Table of contents alert

Latest published articles alert

Accepted manuscripts

Centrosome amplification promotes cell invasion via cell-cell contact disruption and Rap-1 activation

Anu Prakash, Shishir Paunikar, Mark Webber, Emma McDermott, Sri H. Vellanki, Kerry Thompson, Peter Dockery, Hanne Jahns, James A. L. Brown, Ann M. Hopkins, Emer Bourke

Time-resolved proximity biotinylation implicates a porin protein in export of transmembrane malaria parasite effectors

David Anaguano, Watcharatip Dedkhad, Carrie F. Brooks, David W. Cobb, Vasant Muralidharan

Light Activated BioID (LAB): an optically activated proximity labeling system to study protein-protein interactions

Omer Shafraz, Carolyn Marie Orduno Davis, Sanjeevi Sivasankar

Transcription inhibition suppresses nuclear blebbing and rupture independent of nuclear rigidity

Isabel K. Berg, Marilena L. Currey, Sarthak Gupta, Yasmin Berrada, Bao V. Nguyen, Mai Pho, Alison E. Patteson, J. M. Schwarz, Edward J. Banigan, Andrew D. Stephens

Key role for Rac in the early transcriptional response to ECM stiffness and the stiffness-dependent repression of ATF3

Irène Dang, Joseph A. Brazzo, Yongho Bae, Richard K. Assoian

More accepted manuscripts

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STICKY WICKET

CELL SCIENCE AT A GLANCE

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SHORT REPORT

RESEARCH ARTICLE

ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM DEVELOPMENT

IN THIS ISSUE

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